Comparative genomics : basic and applied research / edited by James R. Brown.

Format:

Book

Contributor:

Brown, J. R. (James Raymond), 1956-

Language:

English

Subjects (All):

Genomics.

Physiology, Comparative.

Medical Subjects:

Genomics.

Physiology, Comparative.

Physical Description:

383 pages, 8 unnumbered pages of plates : illustrations (partly color), map ; 25 cm

Place of Publication:

Boca Raton : CRC Press, [2008]

Summary:

When genomic research first came on the scene, much of the biomedical research community viewed it as a limited venture with limited potential. We now know that such an assessment was both premature and inaccurate. In the last ten years, we've witnessed such remarkable acceleration in the merger of basic and applied genomic research that, among other things, genomic research is now thought of as being intrinsic to current drug research. Through rigorous comparative analysis, the genomes of cold-blooded vertebrate, avian, and other mammalian species are providing a deeper understanding of the human genome. This is leading to the development of drugs that may well treat a number of otherwise intractable conditions.

Rather than offering a comprehensive volume covering every aspect of comparative genomics, Comparative Genomics: Basic and Applied Research embodies the diverse interests of prominent researchers. Compiling first hand descriptions of their pioneering work, the text focuses on commonalities and synergies across the broad field of comparative genomics. Among many topics, it covers-

Revolutionary advances in DNA-sequencing technology

Bold new approaches to the organization and analysis of large phylogenetic data sets

The impact of comparative genomics on our understanding of evolution

Efforts toward developing novel antimicrobial drugs through the use of bacterial pathogen genomes

Advanced considerations of genomic research in HIV, AIDS, and cancer, including new drug targets, and epigenomic-based drug therapies.

Genomic applications in agricultural research and livestock breeding

Ultimately, future breakthroughs in comparative genomics will depend upon the continued interaction and interdependency of applied and basic research. This seminal volume demonstrates both the means and the fruits of that cooperation, and in doing so defines and lays the groundwork for continued progress.

Contents:

Introduction: the broad horizons of comparative genomics / James R. Brown

Advances in next-generation DNA sequencing technologies / Michael L. Metzker

Large scale phylogenetic reconstruction / Bernard M.E. Moret

Comparative genomics of viruses using bioinformatics tools / Chris Upton and Elliot J. Lefkowitz

Archaebacteria and the prokaryote-to-eukaryote transition (and the role of mitochondria therein) / William Martin, Tal Dagan, and Katrin Henze

Comparative genomics of invertebrates / Takeshi Kawashima ... [et al.]

Comparative vertebrate genomics / James W. Thomas

Gaining insight into human population-specific selection pressure / Michael R. Barnes

Comparative genomics in drug discovery / James R. Brown

Comparative genomics and the development of novel antimicrobials / Diarmaid Hughes

Comparative genomics and the development of antimalarial and antiparasitic therapeutics / Emilio F. Merino, Steven A. Sullivan, and Jane M. Carlton

Comparative genomics in AIDS research / Philippe Lemey, Koen Deforche, and Anne-Mieke Vandamme

Detailed comparisons of cancer genomes / Timon P.H. Buys ... [et al.]

Comparative cancer epigenomics / Alice N.C. Kuo ... [et al.]

G protein-coupled receptors and comparative genomics / Steven M. Foord

Comparative toxicogenomics in mechanistic and predictive toxicology / Joshua C. Kwekel, Lyle D. Burgoon, and Tim R. Zacharewski

Comparative genomics and crop improvement / Michael Francki and Rudi Appels

Domestic animals: a treasure trove for comparative genomics / Leif Andersson.

Notes:

Includes bibliographical references and index.

ISBN:

9780849392160

0849392160

OCLC:

145014780

Online:

Publisher description