Pharmacogenomics in drug discovery and development / edited by Qing Yan.

Format:

Book

Series:

Methods in molecular biology (Clifton, N.J.) ; 448.

Methods in molecular biology ; 448

Language:

English

Subjects (All):

Pharmacogenomics.

Pharmacogenomics--Laboratory manuals.

Drug development.

Drugs--Effectiveness.

Drugs.

Pharmacogenetics.

Drug Design.

Medical Subjects:

Pharmacogenetics.

Drug Design.

Genre:

Laboratory manuals.

Physical Description:

xiii, 487 pages : illustrations ; 25 cm.

Place of Publication:

Totowa, NJ : Humana Press, 2008.

Summary:

Since each human is genetically distinctive, responding differently to disease-causing factors as well as drugs, the field of pharmacogenomics arose to develop personalized medicine, or medicine that deals with the complexity of the human body. In Pharmacogenomics in Drug Discovery and Development, leading experts present methodical, state-of-the-art contributions covering topics from individual molecules to systemic diseases, examining both fundamental concepts and advanced technologies. Divided into three sections, the volume begins by exploring cutting-edge technologies used to pursue systems-based pharmacogenomics, followed by extensive chapters on gene-drug interactions and the use of pharmacogenomics in therapeutics of diseases. Although not in standard methods in Molecular Biology series format, this book retains the practicality and usefulness of the highly successful series.

Comprehensive and up-to-date, Pharmacogenomics in Drug Discovery and Development is an ideal volume for scientists striving to transform disease treatment into disease prevention.

Features

Examines both fundamental concepts and advanced technologies in pharmacogenomics

Uses cutting-edge technologies to pursue systems-based pharmacogenomics, including bioinformatics, microarray, and association studies

Methodical, state-of-the-art contributions cover topics from individual molecules and gene-drug interactions to systemic diseases

Explores extensive applications of pharmacogenomics in drug development for diseases, including psychiatric disorders, cardiovascular diseases, cancer,

Alzheimer's disease, rheumatoid arthritis, asthma, and infectious diseases

Contents:

Chapter 1 The Integration of Personalized and Systems Medicine: Bioinformatics Support for Pharmacogenomics and Drug Discovery / Qing Yan 1

Chapter 2 Applications of Microarrays and Biochips in Pharmacogenomics / Gary Hardiman 21

Chapter 3 Confounding in Genetic Association Studies and Its Solutions / Donglei Hu, Elad Ziv 31

Chapter 4 Pharmacogenetics of Membrane Transporters: A Review of Current Approaches / Tristan M. Sissung, Erin R. Gardner, Rui Gao, William D. Figg 41

Chapter 5 Pharmacogenomics of Drug-Metabolizing Enzymes and Drug Transporters in Chemotherapy / Tessa M. Bosch 63

Chapter 6 Pharmacogenomics of G Protein-Coupled Receptor Signaling: Insights from Health and Disease / Miles D. Thompson, David E. C. Cole, Pedro A. Jose 77

Chapter 7 G Protein-Coupled Receptors Disrupted in Human Genetic Disease / Miles D. Thompson, Maire E. Percy, W. McIntyre Burnham, David E. C. Cole 109

Chapter 8 G Protein-Coupled Receptor Pharmacogenetics / Miles D. Thompson, Katherine A. Siminoivitch, David E. C. Cole 139

Chapter 9 Epigenetic Alterations of the Dopaminergic System in Major Psychiatric Disorders / Hamid Mostafavi Abdolmaleky, Cassandra L. Smith, Jin-Rong Zhou, Sam Thiagalingam 187

Chapter 10 Pharmacogenomics in Alzheimer's Disease / Ramon Cacabelos 213

Chapter 11 Pharmacogenetics of Asthma / Gregory A. Hawkins, Stephen P. Peters 359

Chapter 12 From SNPs to Functional Studies in Cardiovascular Pharmacogenomics / Sharon Cresci 379

Chapter 13 Pharmacogenomics in Gastrointestinal Disorders / Michael Camilleri, Yuri A. Saito 395

Chapter 14 Pharmacogenomics in Rheumatoid Arthritis / Prabha Ranganathan 413

Chapter 15 Cancer Pharmacogenetics / Sharon Marsh 437

Chapter 16 Pharmacogenomics in the Preclinical Development of Vaccines: Evaluation of Efficacy and Systemic Toxicity in the Mouse Using Array Technology / Karin J. Regnstrom 447

Chapter 17 Pharmacogenomics in the Evaluation of Efficacy and Adverse Events During Clinical Development of Vaccines / Lennart J. Nilsson, Karin J. Regnstrom 469.

ISBN:

1588298876

9781588298874

OCLC:

181090506