Retrotransposition, diversity and the brain / Fred Gage, Yves Christen, (eds.).

Format:

Book

Contributor:

Gage, F. (Fred), 1950-

Christen, Yves.

Series:

Research and perspectives in neurosciences 1861-2253

Research and perspectives in neurosciences, 1861-2253

Language:

English

Subjects (All):

Neurogenetics.

Retroelements--genetics.

Sequence Analysis, DNA.

Biodiversity.

Brain--physiology.

Variation (Genetics).

Medical Subjects:

Retroelements--genetics.

Sequence Analysis, DNA.

Biodiversity.

Brain--physiology.

Variation (Genetics).

Physical Description:

xii, 122 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Berlin ; New York : Springer, [2008]

Summary:

Retroelements are ancient mobile DNA found in most organisms. Long dismissed as useless, selfish or "junk" DNA, they were thought to be mere intracellular parasites from our distant evolutionary past. Together with their mutant relatives. L1 sequences constitute almost 50% of the mammalian genome. L1s can retrotranspose in a defined window of the neuronal differentiation, changing the genetic information in single neurons in a "random" fashion, allowing the brain to develop in distinct different ways. Such strategy contributes to expand the number of functionally distinct neurons that could be produced from a given stem cell gene pool. This characteristic of variety and flexibility may contribute to the uniqueness of an individual brain, even between genetically identical twins. These mobile elements may be part of conserved core process responsible for evoking facilitated complex non-random phenotypical variation on which selection may act. A detailed understanding of the basic mechanisms of L1 activity may shed light on one possible mechanism for generating neural diversity.

The book results from a fascinating and stimulating exchange of ideas at the interface of the complexity of brain organization and function, the mechanisms for generating diversity and genetic mobility. This meeting of leading geneticists, molecular biologists and neuroscientists was organized by the Fondation IPSEN. Its ambitious goal was to expand the current limits of research in neurobiology not only to the benefit of those interested in the cellular and molecular processes but also for the understanding of high-level cognitive functions and the understanding of complex mental diseases. The reader can judge how far the book achieves this.

Contents:

Telomeres and Telomerase in Human Health and Disease / J. Lin, E.S. Epel, E.H. Blackburn 1

Molecular and Circuit Mechanisms for Hippocampal Learning / S. Tonegawa, T.J. McHugh 13

Retrotransposons - Natural and Synthetic / J.D. Boeke, W. An, L. Dai, E.S. Davis, J.S. Han, K.A. O'Donnell, L.Z. Scheifele, S.J. Wheelan 21

Ancient Retrotransposons as Possible Remnants of the Primitive RNP World / R. Ivanyi-Nagy, J.-L. Darlix 33

Human Diversity and L1 Retrotransposon Biology: Creation of New Genes and Individual Variation in Retrotransposition Potential / H.H. Kazazian, M.d.C. Seleme, D.V. Babushok, D.M. Ostertag, M.R. Vetter, P.K. Mandal 43

From the "RNA World" to Brain Complexity: Generation of Diversity / A.R. Mutori, M.C.N. Marchetto, F.H. Gage 53

Endogenous Retroviruses and Human Neuropsychiatric Disorders / R.H. Yolken, H. Karlsson, I. Bossis, L. Asp, F. Dickerson, C. Nell&aaa;ker, M. Elashoff, E. Rubalcaba, R.P. Viscidi 65

Is Psychosis Due to Retroviral/Retrotransposon Integration Close to the Cerebral Dominance Gene? / T.J. Crow, J.S. Close, H.-S. Kim, M.T. Ross 87

Microcephalies and DNA Repair / E.C. Gilmore, C.A. Walsh 109.

Notes:

Includes bibliographical references and index.

ISBN:

9783540749653

3540749659

OCLC:

209592721