General principles of tumor immunotherapy : basic and clinical applications of tumor immunology / edited by Howard L. Kaufman and Jedd D. Wolchok.

Format:

• Book

Contributor:

• Kaufman, Howard L.
• Wolchok, Jedd D.

Language:

English

Subjects (All):

• Cancer--Immunotherapy.
• Cancer vaccines.
• Neoplasms--therapy.
• Neoplasms--immunology.
• Immunotherapy.
• Cancer Vaccines--therapeutic use.

Medical Subjects:

• Neoplasms--therapy.
• Neoplasms--immunology.
• Immunotherapy.
• Cancer Vaccines--therapeutic use.

Physical Description:

xii, 503 pages : illustrations ; 25 cm

Place of Publication:

Dordrecht : Springer, [2007]

Summary:

General Principles of Tumor Immunotherapy: Basic and Clinical Applications of Tumor Immunology brings together the world's leading authorities on tumor immunology. This book describes the basic immunology principles that form the foundation of understanding how the immune system recognizes and rejects tumor cells. The role of the innate and adaptive immune responses is discussed and the implications of these responses for the design of clinical strategies to combat cancer are illustrated through both experimental clinical trials and review of current standard of care therapeutic agents. This information will be invaluable to both students of immunology and cancer research and practicing physicians who have patients with cancer. The book provides a comprehensive overview of the field, demonstrates how advances in basic immunology can and are being applied to cancer, and describes the current status of approved immunotherapy regimens.

Contents:

• A perspective on cancer immunology and immunotherapy / Alan N. Houghton
• Tumor antigens / Michael A. Morse, Timothy M. Clay, and H. Kim Lyerly
• T cells and antigen recognition / Leisha A. Emens
• The role of natural killer T cells in tumor immunity / Madhav V. Dhodapkar
• Immunomodulatory molecules of the immune system / Yvonne M. Saenger, Robert R. Jenq, and Miguel-Angel Perales
• HLA class I antigen abnormalities in tumors / Barbara Seliger and Soldano Ferrone
• The local tumor microenvironment / Theresa L. Whiteside
• Peptide and protein vaccines for cancer / Raymond M. Wong and Jeffrey S. Weber
• DNA vaccines against cancer / Adam D. Cohen and Jedd D. Wolchok
• Recombinant viral and bacterial vaccines / Douglas W. Grosenbach ... [et al.]
• Dendritic cell vaccines / Sylvia Adams, Nina Bhardwaj, and David W. O'Neill
• Whole cell vaccines / Mark B. Faries and Donald L. Morton
• Carbohydrate vaccines against cancer / Philip O. Livingston and Govind Ragupathi
• Monoclonal antibody therapy of cancer / Joseph G. Jurcic, Deborah A. Mulford, and David A. Scheinberg
• Adoptive cellular therapy for the treatment of cancer / Cassian Yee
• Checkpoint blockade and combinatorial immunotherapies / Karl S. Peggs, Sergio A. Quezada, and James P. Allison
• General approaches to measuring immune responses / Mary L. Disis and Keith L. Knutson
• Interferon therapy / Stergios J. Moschos and John M. Kirkwood
• High dose interleuken-2 therapy / Christian A. Petrulio, Gail DeRaffele, and Howard L. Kaufman
• Monoclonal antibodies in cancer therapy / Christoph Rader and Michael R. Bishop
• Unmasking tumor cell immunogenicity by chemotherapy: implications for therapy / Irma Larma, Robbert G. van der Most, and Richard A. Lake.

Notes:

Includes bibliographical references and index.

ISBN:

• 9781402060861
• 1402060866

OCLC:

144228494