Heat shock proteins : potent mediators of inflammation and immunity / edited by Alexzander A. A. Asea and Antonio De Maio.

Format:

Book

Contributor:

Asea, Alexzander A. A.

De Maio, Antonio.

Series:

Heat shock proteins (Series) ; v. 1.

Heat shock proteins ; v. 1

Language:

English

Subjects (All):

Heat shock proteins.

Immune response--Regulation.

Immune response.

Heat-Shock Proteins.

Inflammation Mediators.

Medical Subjects:

Heat-Shock Proteins.

Inflammation Mediators.

Physical Description:

xii, 357 pages : illustrations ; 25 cm.

Place of Publication:

Dordrecht : Springer, [2007]

Summary:

Series Editors:

Heat Shock Proteins: Potent Mediators of Inflammation and Immunity Currently provides the most up-to-date review on new mechanisms and provides exciting insights into how heat shock proteins modulate the hosts immune response. Written by leaders in the field of heat shock protein immunobiology, the chapters systematically and in a step wise fashion takes the reader through the fascinating sequence of events by which heat shock proteins activate immune responses and provides answers as to its biological significance to the host. From the early stages of binding and receptors mediated signalling, to new paradigms by which heat shock proteins are released into the circulation, to antigen processing and presentation, and finally to the immune response itself this book is a must read for graduates and postgraduates in the field of Biology (plant and mammal), Biochemistry (pro- and eukaryotic), Immunology, Microbiology, Exercise Medicine, Physiology, Inflammatory diseases, Autoimmunity, Pharmacology and Pathology.

Contents:

Part I Mechanisms of Heat Shock Protein Release

1 Release of Heat Shock Proteins: Passive Versus Active Release Mechanisms / Alexzander A.A. Asea 3

2 HSP70 Peptide Acting as a Danger Signal for Natural Killer (NK) Cells / Gabriele Multhoff 21

3 Mechanisms of stress-induced Cellular HSP72 Release / Graeme I. Lancaster, Mark A. Febbraio 31

4 Roles of Extracellular Heat Shock Proteins: A New Sense of Danger / John H.H. Williams, Claire Hunter-Lavin 39

Part II Heat Shock Protein Binding and Receptor-Mediated Signaling

5 Macrophages and the Stress Response / Virginia L. Vega, Antonio De Maio 61

6 Heat Shock Proteins and Scavenger Receptors / Yves Delneste, Sebastein Jaillon, Pascale Jeannin 75

7 The Inside Story: Anti-Inflammatory Roles of HSF1 and Heat Shock Proteins / Stuart K. Calderwood, Xianzhong Xiao, Yue Xie 95

8 Interaction of Heart Shock Protein 60 with Innate Immune Cells / Christiane Habich, Volker Burkart 115

Part III Immune Responses Elicited by Heat Shock Proteins

9 HSP-APC Interactions: Initiation of Immune Responses / Robert J. Binder, Pramod K. Srivastava 131

10 Extracellular Functions for an Intracellular Protein: GRP94/GP96 Interactions with the Mammalian Immune System / Deanna Carrick Crossman, Christopher V. Nicchitta 147

11 HSP-Induced Stimulation of Immune Responses / Thomas Lehner, Yufei Wang, Trevor Whittall, Lesley A. Bergmeier, Kaboutar Babaahmady, Charles Kelly 159

12 The Role of Heat Shock Proteins in the Elicitation of Immune Responses / Charles A Gullo, Paul Macary, Michael Graner 173

13 Hsp70 Family Members, Danger Signals and Autoimmunity / Douglas G. Miller, Pamela S. Ohashi 189

14 The Immune Response Under Stress: Class I HLA Presentation of host-derived peptides / Angela Wahl, Oriana Hawkins, Curtis McMurtrey, Heather Hickman-Miller, Jon Weidanz, William Hildebrand 213

15 Extracellular HSP72: A Double-edged Sword for Host Defense / Monika Fleshner, John D. Johnson, Joshua Friedman 235

16 HSP60: A Pleiotropic Immune Signal / Alexandra Zanin-Zhorov, Irun R. Cohen 265

Part IV Antigen Processing, Presentation and Effect on Inflammation and Disease

17 Impact of HSP-chaperoned Peptides on the MHC Class II-dependent Presentation and Activation of CD4 + T Cells in Regard of Allo- and Autoantigens / Markus Haug, Gunther E. Dannecker, Ursula Holzer 275

18 Heat Shock Proteins are Targets for T Cell Regulation: How Microbial HSP Induce IL10 Producing Anti-inflammatory T Cells / Willen van Eden 289

19 The Pro- and Anti-Inflammatory Properties of the Stress Protein GP96 / A. Graham Pockley, Munitta Muthana 309

20 Anti-Tumor Response and Heat Shock Proteins (HSP): A Friend or Fore Relationship? / Susana Fiorentino, Alfonso Barreto, Diana Castaneda, Claudia Cifuentes 321

21 Heat Shock Proteins and the Resolution of Inflammation by Lymphocytes / Mark I. Hirsh, Wolfgang G. Junger 337.

Notes:

Includes bibliographical references and index.

ISBN:

9781402055843

1402055846

1402055854

9781402055850

OCLC:

144222182