Handbook of molecular force spectroscopy / edited by Aleksandr Noy.

Format:

Book

Contributor:

Noy, Aleksandr.

Language:

English

Subjects (All):

Molecular spectroscopy--Handbooks, manuals, etc.

Molecular spectroscopy.

Genre:

Handbooks and manuals.

Physical Description:

xii, 291 pages : illustrations ; 27 cm

Place of Publication:

New York, NY : Springer, [2008]

Summary:

Modern materials science and biophysics are increasingly focused on studying and controlling intermolecular interactions on the single-molecule level. Molecular force spectroscopy was developed in the past decade as the result of several unprecedented advances in the capabilities of modern scientific instrumentation, and defines a number of techniques that use mechanical force measurements to study interactions between single molecules and molecular assemblies in chemical and biological systems. Examples of these techniques, which typically target a specific range of experimental systems and geometries, include atomic force microscopy, optical tweezers, surface forces apparatus, and magnetic tweezers.

With contributions by internationally renowned scientists, Handbook of Molecular Force Spectroscopy is a comprehensive, state-of-the-art review of modern force spectroscopy, including fundamentals of intermolecular forces, technical aspects of the force measurements, and practical applications. The Handbook reviews the fundamental physical concepts of loading single and multiple chemical bonds on the nanometer scale, covers practical aspects of modern single-molecule level techniques, and describes a number of representative applications of force spectroscopy to the study of chemical and biological processes. Computer modeling of force spectroscopy experiments is addressed as well. In sum, this volume is an authoritative guide to planning, understanding, and analyzing modern molecular force spectroscopy experiments with an emphasis on biophysical research.

Contents:

1 Surface Force Apparatus Measurements of Molecular Forces in Biological Adhesion / Deborah Leckband 1

2 Force Spectroscopy with Optical and Magnetic Tweezers / Richard Conroy 23

3 Chemical Force Microscopy Nanoscale Probing of Fundamental Chemical Interactions / Aleksandr Noy, Dmitry V. Vezenov, Charles M. Lieber 97

4 Chemical Force Microscopy: Force Spectroscopy and Imaging of Complex Interactions in Molecular Assemblies / Dmitry V. Vezenov, Aleksandr Noy, Charles M. Lieber 123

5 Dynamic Force Spectroscopy with the Atomic Force Microscope / Phil Williams 143

6 Simulation in Force Spectroscopy / David L. Patrick 163

7 Tip Functionalization: Applications to Chemical Force Spectroscopy / Craig D. Blanchette, Albert Loui, Timothy V. Ratto 185

8 The Dynamical Response of Proteins Under Force / Kirstine L. Anderson, Sheena E. Radford, D. Alastair Smith, David J. Brockwell 205

9 Counting and Breaking Single Bonds: Dynamic Force Spectroscopy in Tethered Single Molecule Systems / Todd A. Sulchek, Raymond W. Friddle, Aleksandr Noy 251

10 Direct Mapping of Intermolecular Interaction Potentials / Paul D. Ashby 273.

Notes:

Includes bibliographical references and index.

ISBN:

9780387499871

0387499873

OCLC:

166358169