Clinical bioinformatics / edited by Ronald J. A. Trent.

Format:

Book

Contributor:

Trent, R. J.

Series:

Methods in molecular medicine ; 141.

Methods in molecular medicine ; 141

Language:

English

Subjects (All):

Bioinformatics.

Computational biology.

Genomics--Data processing.

Genomics.

Decision Making, Computer-Assisted.

Computational Biology.

Medical Informatics.

Oligonucleotide Array Sequence Analysis.

Medical Subjects:

Decision Making, Computer-Assisted.

Computational Biology.

Medical Informatics.

Oligonucleotide Array Sequence Analysis.

Physical Description:

xi, 382 pages : illustrations ; 24 cm.

Place of Publication:

Totowa, N.J. : Humana Press, 2007.

Summary:

A challenge in clinical medicine is dealing with an ever increasing volume of information. This is particularly so in the emerging "omics" era, and impacts on researchers, health professionals and the broader community. To respond to this challenge requires computer-based storage, processing and dissemination i.e. bioinformatics. In this volume of the Methods in Molecular Medicine, a number of strategies utilizing clinical bioinformatics are described. This series of articles focuses on software applications that can be used to translate information into outcomes of clinical relevance. The six themes covered include:

1. Gene discovery?? Chapters 1 to 4.

2. Gene function (microarrays) - Chapters 5 to 9.

3. DNA mutation analysis?? Chapters 10 to12. 4. Proteomics?? Chapters 13 to 15.

5. Online approaches and resources?? Chapters 16 and 17.

6. Informatics in clinical practice?? Chapters 18 and 19.

Contents:

In silico gene discovery / Bing Yu

Whole genome-wide association study using affymetrix SNP chip: a two-stage sequential selection method to identify genes that increase the risk of developing complex diseases / Howard H. Yang ... [et al.]

Utilizing HapMap and tagging SNPs / Christopher A. Haiman and Daniel O. Stram

Measuring the effects of genes and environment on complex traits / Jennifer H. Barrett

Microarrays-planning your experiment / Jean Yee Hwa Yang

Clinical uses of microarrays in cancer research / Carl Virtanen and James Woodgett

Microarrays-analysis of signaling pathways / Anassuya Ramachandran ... [et al.]

Microarrays-identifying molecular portraits for prostate tumors with different Gleason patterns / Alexandre Mendes, Rodney J. Scott, and Pablo Moscato

Microarrays for the study of viral gene expression during human cytomegalovirus latent infection / Barry Slobedman and Allen K.L. Cheung

Computer-assisted reading of DNA sequences / Huong Le ... [et al.]

Evaluating DNA sequence variants of unknown biological significance / Scott A. Grist, Andrew Dubowsky, and Graeme Suthers

Developing a DNA variant database / David C.Y. Fung

Protein comparative sequence analysis and computer modeling / Brett D. Hambly, Cecily E. Oakley, and Piotr G. Fajer

Identification and characterization of microbial proteins using peptide mass fingerprinting strategies / Jonathan W. Arthur

Statistical analysis of image data provided by two-dimensional gel electrophoresis for discovery proteomics / Ben Crossett ... [et al.]

Online resources for the molecular contextualization of disease / Chi N.I. Pang and Marc R. Wilkins

Web-based resources for clinical bioinformatics / Anthony M. Joshua and Paul C. Boutros

Developing decision support systems in clinical bioinformatics / Vitali Sintchenko and Enrico Coiera

eConsulting / Siaw-Teng Liaw and Peter Schattner.

ISBN:

9781588297914

1588297918

OCLC:

166627305