Pharmacological mechanisms in Alzheimer's therapeutics / A. Claudio Cuello, editor.

Format:

Book

Contributor:

Cuello, A. C. (A. Claudio)

Language:

English

Subjects (All):

Alzheimer's disease.

Alzheimer's disease--Chemotherapy.

Alzheimer's disease--Chemotherapy--Technological innovations.

Alzheimer Disease.

Alzheimer Disease--drug therapy.

Technological innovations.

Medical Subjects:

Alzheimer Disease.

Alzheimer Disease--drug therapy.

Physical Description:

xx, 319 pages : illustrations ; 25 cm

Place of Publication:

New York ; London : Springer, [2008]

Summary:

Alzheimer's is the most common dementia in the elderly. The need for effective therapy of dementia is greater than ever, but there is not, as yet, a drug therapy which can stop or reverse the clinical consequences. There is, however, a great deal of anticipation on the imminent development of effective, disease-modifying therapies. The remarkable progress made by the scientific community in unraveling molecular and cellular aspects of the Alzheimer's pathology has allowed the identification of a number of promising targets for drug development. Investigation of these targets and the evolution of ongoing strategies to develop efficacious therapies for this devastating neurodegenerative condition is the central theme of Pharmacological Mechanisms in Alzheimer's Therapeutics. The current and future therapies based on this new knowledge of the Alzheimer's pathology are dealt with by contributors who have been most influential in bringing this new knowledge and in the development of experimental and presently applied therapies. The book should be of interest to medical professionals and basic scientists alike since it provides ideas about current trends in Alzheimer's therapeutics to the general public.

Contents:

1 Overview of the Alzheimer's Disease Pathology and Potential Therapeutic Targets / A. Claudio Cuello 1

2 Trial Designs and Outcomes to Monitor Novel Therapeutics in Alzheimer's Disease / Serge Gauthier 28

3 The Pharmacological Treatment of Alzheimer's Disease with Cholinesterase Inhibitors and Memantine / Gordon Keith Wilcock 36

4 M1 Muscarinic Agonists: A Comprehensive Therapy Against Major Hallmarks of Alzheimer's Disease / Abraham Fisher 50

5 Cholinergic Neurodegeneration in Alzheimer's Disease: Basis for Nerve Growth Factor Therapy / Ahmad Salehi, Alexander Kleshevnikov, William C. Mobley 64

6 The Rationale for Glutamatergic Therapy in Alzheimer's Disease / Paul T. Francis 105

7 Secretases as Pharmacological Targets in Alzheimer's Disease / Nigel M. Hooper, Emma R. L. C. Vardy 113

8 [gamma]-Secretase as a Target for Alzheimer's Disease / Michael S. Wolfe 125

9 The Rationale for an Immunological Approach to Alzheimer's Therapeutics / Dave Morgan 141

10 Neuroinflammation, Alzheimer Disease, and Other Aging Disorders / Edith G. McGeer, Patrick L. McGeer 149

11 Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Derived A[beta]42-Lowering Molecules for Treatment and Prevention of Alzheimer's Disease (AD) / Sascha Weggen, Eva Czirr, Stefanie Leuchtenberger, Jason Eriksen 167

12 The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics / Paula I. Moreira, Mark A. Smith, Xiongwei Zhu, Akihiko Nunomura, George Perry 194

13 Apolipoprotein E: A Potent Gene-Based Therapeutic Target for the Treatment of Sporadic Alzheimer's Disease / Judes Poirier 212

14 Tau Pathology as a Target in Alzheimer's Therapeutics / Khalid Iqbal, Inge Grundke-Iqbal 223

15 Design of Inhibitors of Amyloid-[beta] Misfolding and Aggregation for Alzheimer's Therapy / Lisbell D. Estrada, Cristian Lasagna, Claudio Soto 238

16 Potential Applications of Glycosaminoglycan-Related Compounds in Alzheimer's Disease / Celine Morissette, Diane Lacombe, Xianqi Kong, Ahmed Aman, Pascale Krzywkowski, Lioudmila Rodionova, Mounia Azzi, Daniel Delorme, Barry D. Greenberg 255

17 Multifunctional Neuroprotective Drugs for the Treatment of Alzheimer's Disease / Cornelis J. Van der Schyf, Werner J. Geldenhuys, Moussa B. H. Youdim 274

18 Interpreting Clinical Studies of Putative Therapeutics for Alzheimer's Disease: The Case of Statins and NSAIDs / Benjamin Wolozin 296.

Notes:

Includes bibliographical references and index.

ISBN:

0387715215

9780387715216

OCLC:

190843291