Specialization and complementation of humoral immune responses to infection / Tim Manser, editor.

Format:

Book

Contributor:

Manser, Tim.

Series:

Current topics in microbiology and immunology ; 319.

Current topics in microbiology and immunology ; 319

Language:

English

Subjects (All):

Immunology.

Complement (Immunology).

B cells.

Allergy and Immunology.

Complement Factor B.

Medical Subjects:

Allergy and Immunology.

Complement Factor B.

Physical Description:

xii, 159 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Berlin : Springer, [2008]

Summary:

In recent years the results of past studies on T cell dependent and T cell independent antibody responses have coalesced with discoveries regarding the roles of various primary B cell subsets and components of the innate immune system in conferring resistance to infectious pathogens. As a consequence, a new and more complete understanding of how antibody-mediated resistance to pathogens is elaborated has emerged. The recent explosion of knowledge of Toll-like receptor specificity and function has further embellished this understanding. It is now clear that there is not only extensive overlap and cross-complementarity in the action of innate and adaptive immune systems, but also specialization of function of the various B cell subsets and the types of antibodies they produce. This synergistic interaction of multiple components of these systems is perhaps best exemplified in antibody responses to bacteria. Contributions to this monograph were chosen to highlight this new perspective on antibody responses to infection, as well as to convey its practical implications, such as for contemporary vaccine design.

Contents:

Pattern Recognition by B Cells: The Role of Antigen Repetitiveness Versus Toll-Like Receptors / H. J. Hinton, A. Jegerlehner, M. F. Bachmann 1

The Multifunctional Role of Antibodies in the Protective Response to Bacterial T Cell-Independent Antigens / J. J. Mond, J. F. Kokai-Kun 17

B Cell Lineage Contributions to Antiviral Host Responses / N. Baumgarth, Y. S. Choi, K. Rothaeusler, Y. Yang, L. A. Herzenberg 41

The Important and Diverse Roles of Antibodies in the Host Response to Borrelia Infections / T. J. LaRocca, J. L. Benach 63

A Distinct Role for B1b Lymphocytes in T Cell-Independent Immunity / K. R. Alugupalli 105

Secretory Immunity Following Mutans Streptococcal Infection or Immunization / D. J. Smith, R. O. Mattos-Graner 131.

Notes:

Includes bibliographical references and index.

ISBN:

9783540738992

3540738991

9783540739005

3540739009

OCLC:

171563572