MIF : most interesting factor / editor, Richard Bucala.

Format:

Book

Contributor:

Bucala, Richard.

Language:

English

Subjects (All):

Macrophage migration inhibitory factor.

Macrophage Migration-Inhibitory Factors--physiology.

Macrophage Migration-Inhibitory Factors--genetics.

Macrophage Migration-Inhibitory Factors--immunology.

Medical Subjects:

Macrophage Migration-Inhibitory Factors--physiology.

Macrophage Migration-Inhibitory Factors--genetics.

Macrophage Migration-Inhibitory Factors--immunology.

Physical Description:

xii, 317 pages : illustrations (some color), color map ; 24 cm

Place of Publication:

Hackensack, NJ : World Scientific, [2007]

Summary:

In recent years, researchers have identified a pivotal, upstream role for macrophage migration inhibitory factor (MIF) in the innate immune response. This pioneering book describes this renaissance of knowledge in the biology of MIF. Topics covered include MIF's molecular mechanism of action, its counterregulatory action on the immunosuppressive properties of glucocorticoids, its role in the production of proinflammatory mediators as shown in cell-based and animal studies; and its central role in human inflammation. Human genetic studies have identified allelic forms of the MIF gene, and high-expression alleles have been associated with rheumatoid arthritis, asthma severity, sarcoidosis, atopy, inflammatory bowel disease, and other inflammatory and infectious maladies. The book also discusses the role of MIF as a therapeutic target. Unique structural features of the protein, such as an intrinsic catalytic activity and the recent discovery of its cell surface receptor, offer attractive opportunities for therapeutic intervention. Such approaches are presently in clinical development. Book jacket.

Contents:

Historical overview / John R. David

MIF "rediscovered" / Richard Bucala

Immunopathologic mechanisms relevant to diseases / Hui Y. Lan

Structural studies of MIF / Elias Lolis and Gregg Crichlow

MIF redox activity / Jürgen Bernhgaen

MIF receptor-mediated signal transduction / Lin Leng

MIF in innate immunity and infectious diseases / Chloé Kaech, Thierry Roger and Thierry Calandra

MIF in parasitic and helminthic infections / Heidi M. Snider ... [et al.]

MIF in the pathogenesis of kidney disease / Gregory H. Tesch, Robert C. Atkins and David J. Nikolic-Paterson

MIF and CNS autoimmune disease / Claudia M. Denkinger and Thomas G. Forsthuber

MIF: wound repair / Matthew J. Hardman and Gillian S. Ashcroft

MIF and atherosclerosis / Christian Weber and Andreas Schober

Inflammatory arthritis / Eric F. Morand and Michelle Leech

Gene structures and functional MIF polymorphisms in respiratory disease / John Baugh

MIF alleles in infammatory arthritis / Rachelle Donn and David Ray

Adhesion-dependent signaling and growth control / Robert Mitchell.

Notes:

Includes bibliographical references and index.

ISBN:

9812706488

9789812706485

OCLC:

122499855