Pharmacotherapy of diabetes: new developments : improving life and prognosis for diabetic patients / edited by Carl Erik Mogensen.

Format:

Book

Contributor:

Mogensen, Carl Erik.

Language:

English

Subjects (All):

Diabetes--Chemotherapy.

Diabetes.

Diabetes Mellitus--drug therapy.

Insulin--therapeutic use.

Hypoglycemic Agents--therapeutic use.

Medical Subjects:

Diabetes Mellitus--drug therapy.

Insulin--therapeutic use.

Hypoglycemic Agents--therapeutic use.

Physical Description:

xv, 289 pages : illustrations ; 26 cm

Place of Publication:

New York : Springer, 2007.

Summary:

In the United States, 20.8 million children and adults, 7% of the population, have diabetes. While an estimated 14.6 million have been diagnosed, 6.2 million have yet to be diagnosed. Worldwide diabetes afflicts 150 million people. The World Health Organization estimates that by 2025 that figure will double. Diabetes is responsible for more deaths than AIDS and breast cancer, combined. It is a leading cause of blindness, kidney failure, amputations, heart complications and stroke.

Treatment of Type 1 and Type 2 diabetes has changed radically over the past few years. There are new opportunities for treating the key abnormality in diabetes, increased blood glucose, by effective agents such as new insulin preparations and oral agents. Increasing so-called non-glycemic intervention is of prime importance. Blood pressure lowering therapies, anti-cholesterol strategies, and specific treatment related to complications is becoming increasingly important. Pharmacotherapy of Diabetes: New Developments is a unique, invaluable guide to all aspects of the pharmacological treatment of diabetes, covering basic concepts and an in-depth review of current and future therapies. This work provides an overview for the new changes in therapies that can be implemented in clinical practice and treatment of the diabetic patient.

Contents:

Section: Dedication and Introduction / Carl Erik Mogensen v

Aperitif / Edwin Gate, UK vii

Section: Overview

1 Pharmacoepidemiology of Diabetes / Jorgen Rungby, Andrew J. Krentz 3

2 New Definitions of Diabetes: Consequences / Knut Borch-Johnsen 9

Section: Pharmacotherapy of Diabetes

3 The Insulin Resistance Syndrome: Concept and Therapeutic Approaches / Gerald M. Reaven 19

4 Medical Emergencies - Diabetic Ketoacidosis and Hyperosmolar Hyperglycaemia / Niels Moller, K. George M.M. Alberti 31

5 Notes on the Use of Glucagon in Type 1 Diabetes / Carl Erik Mogensen 39

6 Insulin and New Insulin Analogues, Insulin Pumps and Inhaled Insulin in Type 1 Diabetes / Kjeld Hermansen 41

7 Insulin and New Insulin Analogues with Focus on Type 2 Diabetes / Sten Madsbad 53

8 The Place of Insulin Secretagogues in the Treatment of Type 2 Diabetes in the Twenty-First Century / Harald Stingl, Guntram Schernthaner 67

9 Metformin - from Devil to Angel / Guntram Schernthaner, Gerit Holger Schernthaner 77

10 The Glitazones, Lessons so Far / Monika Shirodkar, Serge Jabbour 87

11 Antidiabetic Combination Therapy / Henning Beck-Nielsen, Jan Erik Henriksen 99

12 The Incretin Modulators - Incretin Mimetics (GLP-1 Receptor Agonists) and Incretin Enhancers (DPP-4 Inhibitors) / Michael A. Nauck, Wolfgang E. Schmidt, Juris J. Meier 111

13 The Role of Alpha-Glucosidase Inhibitors (Acarbose) / Markolf Hanefeld, Frank Schaper 143

14 Multifactorial Intervention in Type 2 Diabetes / Oluf Pedersen 153

Section: Treating the Comorbid Patient

15 Obesity and Pharmacological Treatment / Bjorn Richelsen 167

16 Management of Diabetic Dyslipidaemia / D. John Betteridge 173

17 Coronary Intervention and Ischemic Cardioprotection in Diabetic Patients / Torsten Toftegaard Nielsen 187

Section: Diabetic Complications and Side-effects

18 ACE-I and ARB and Blood Pressure Lowering, Including Effect on Renal Disease. Treatment of Advanced Diabetic Renal Disease / Per Logstrup Poulsen, Johan V. Poulsen 201

19 Aspirin and Antiplatelet Drugs in the Prevention of Cardiovascular Complications of Diabetes / Alberto Zanchetti 211

20 Glycosylation Inhibitors, PKC Inhibitors and Related Interventions Against Complications / Aino Soro-Paavonen, Mark Cooper 219

21 Diabetic Foot Ulcers / Andrew Boulton, Frank Bowling 229

22 Pharmacotherapy in Diabetic Neuropathy / Anders Dejgaard, Jannik Hilsted 237

23 Pregnancy - Pharmacological Problems / Elisabeth R. Mathiesen, Peter Damm 249

24 Pharmacotherapy of Diabetic Retinopathy / Toke Bek 255

25 Pharmacotherapy in Diabetic Sexual Dysfunction / Niels Ejskjaer 261

26 A Bone Perspective / Lars Rejnmark 267

Section: Notes from Major Pharmaceutical Companies (all major companies asked to participate)

27 Achieving Guideline Control with New Pharmacotherapies: Albumin-Binding by Acylation of Insulin and GLP-1 / Mads Krogsgaard Thomsen 273

28 Pharmacotherapy of Diabetes / Post Scriptum by the Editor 277.

Notes:

Includes bibliographical references and index.

ISBN:

0387697365

9780387697369

OCLC:

123374509