Integration in respiratory control : from genes to systems / Marc J. Poulin, Richard J.A. Wilson, editors.

Format:

Book

Conference/Event

Contributor:

Poulin, Marc J.

Wilson, Richard J. A.

Conference Name:

Oxford Conference (10th : 2006 : Lake Louise, Alta.)

Series:

Advances in experimental medicine and biology ; v. 605.

Advances in experimental medicine and biology ; v. 605

Language:

English

Subjects (All):

Respiration--Regulation--Congresses.

Respiration.

Respiration--Regulation.

Respiratory Physiological Phenomena.

Medical Subjects:

Respiration.

Respiratory Physiological Phenomena.

Genre:

Conference papers and proceedings.

Physical Description:

xxxi, 541 pages : illustrations (some color) ; 24 cm.

Place of Publication:

New York, N.Y. : Springer, [2008]

Contents:

Part I Historical and Future Perspectives of the Control of Breathing

1 History of Measuring O[subscript 2] and CO[subscript 2] Responses / John W. Severinghaus 3

2 J.S. Haldane and Some of His Contributions to Physiology / John B. West 9

3 Control of the Exercise Hyperpnea: The Unanswered Question / Brian J. Whipp 16

Part II Oxygen Sensing and the Carotid Body

4 A Peripheral Oxygen Sensor Provides Direct Activation of an Identified Respiratory CPG Neuron in Lymnaea / Harold J. Bell, Takuya Inoue, Naweed I. Syed 25

5 Environmental Hyperoxia and Development of Carotid Chemoafferent Function / Gerald Bisgard, Julie Wenninger, Zunyi Wang, E. Burt Olson, Jr. 30

6 HSP70 Reduces Chronic Hypoxia-Induced Neural Suppression via Regulating Expression of Syntaxin / Guanghe Fei, Conghui Guo, Hong-Shuo Sun, Zhong-Ping Feng 35

7 Effect of Systemic Administration of the Nitric Oxide Synthase Inhibitor L-NMMA on the Human Ventilatory Response to Hypoxia / Kojiro Ide, Matthew Worthley, Todd Anderson, Marc J. Poulin 41

8 Effects of Volatile Anesthetics on Carotid Body Response to Hypoxia in Animals / Jaideep J. Pandit, Kevin O'Gallagher 46

9 Mutation of the von Hippel-Lindau Gene Alters Human Cardiopulmonary Physiology / T.G. Smith, J.T. Brooks, G.M. Balanos, T.R. Lappin, D.M. Layton, D.L. Leedham, C. Liu, P.H. Maxwell, M.F. McMullin, C.J. McNamara, M.J. Percy, C.W. Pugh, P.J. Ratcliffe, N.P. Talbot, M. Treacy, P.A. Robbins 51

10 Intravenous Endothelin-1 and Ventilatory Sensitivity to Hypoxia in Humans / Nick P. Talbot, George M. Balanos, Peter A. Robbins, Keith L. Dorrington 57

11 Key Roles for AMP-activated Protein Kinase in the Function of the Carotid Body? / Christopher N. Wyatt, Selina A. Pearson, Prem Kumar, Chris Peers, D. Grahame Hardie, A. Mark Evans 63

12 Stimulatory Actions of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Rat Carotid Glomus Cells / Fenglian Xu, Frederick W. Tse, Amy Tse 69

13 Post-hypoxic Unstable Breathing in the C57BL/6J Mouse: Effects of Acetazolamide / Motoo Yamauchi, Jesse Dostal, Kingman P. Strohl 75

Part III Respiratory Rhythm Generation

14 Catecholaminergic Modulation of the Respiratory Rhythm Generator in the Isolated Brainstem-Spinal Cord Preparation from Neonatal Rat / Akiko Arata, Morimitsu Fujii 83

15 What Role Do Pacemakers Play in the Generation of Respiratory Rhythm? / Christopher A. Del Negro, Ryland W. Pace, John A. Hayes 88

16 Pre-Botzinger Complex Neurokinin-1 Receptor Expressing Neurons in Primary Cell Culture / Sheree M. Johnson 94

17 Belt-and-Suspenders as a Biological Design Principle / Nicholas M. Mellen 99

18 Two Modes of Respiratory Rhythm Generation in the Newborn Rat Brainstem-Spinal Cord Preparation / Hiroshi Onimaru, Ikuo Homma 104

19 Possible Roles of the Weakly Inward Rectifying K[superscript +] Channel Kirk4.1 (KCNJ10) in the Pre-Botzinger Complex / Nestoras Papadopoulos, Stefan M. Winter, Kai Hartel, Melanie Kaiser, Clemens Neusch, Swen Hulsmann 109

20 Contribution of Pacemaker Neurons to Respiratory Rhythms Generation in vitro / Fernando Pena 114

21 Emergent Bursting in Small Networks of Model Conditional Pacemakers in the pre-Botzinger Complex / Jonathan E. Rubin 119

Part IV Genes and Development

22 Brain Nuclei Controllingthe Spinal Respiratory Motoneurons in the Newborn Mouse / Michelle Bevengut, Patrice Coulon, Gerard Hilaire 127

23 Superoxide Dismutase-1 Influences the Timing and Post-hypoxic Stability of Neonatal Breathing / Kevin J. Cummings, Dan Kalf, Sherry Moore, B. Joan Miller, Frank R. Jirik, Richard J.A. Wilson 133

24 Neurodevelopmental Abnormalities in the Brainstem of Prenatal Mice Lacking the Prader-Willi Syndrome Gene Necdin / Silvia Pagliardini, Jun Ren, Rachel Wevrick, John J. Greer 139

25 Consequences of Prenatal Exposure to Diazepam on the Respiratory Parameters, Respiratory Network Activity and Gene Expression of [alpha]1 and [alpha]2 Subunits of GABA[subscript A] Receptor in Newborn Rat / Nathalie Picard, Stephanie Guenin, Yolande Perrin, Gerard Hilaire, Nicole Larnicol 144

26 Modulation of Perinatal Respiratory Rhythm by GABA[subscript A] - and Glycine Receptor-mediated Chloride Conductances / Jun Ren, John J. Greer 149

27 Laryngeal Stimulation by an Acid Solution in the Pre-term Lamb / Marie St-hilaire, Nathalie Samson, Charles Duvareille, Jean-Paul Praud 154

28 Necdin Gene, Respiratory Disturbances and Prader-Willi Syndrome / Sebastien Zanella, Magali Barthelemy, Francoise Muscatelli, Gerard Hilaire 159

Part V Models of Gas Exchange

29 Quantitative Analysis of the Oxygen Transfer in the Human Acinus / Marcel Filoche, Andre A. Moreira, Jose S. Andrade, Jr., Bernard Sapoval 167

30 Role of Diffusion Screening in Pulmonary Diseases / Bernard Sapoval, Marcel Filoche 173

31 A dp/dt Method to Assess Dynamic Properties of Lung Mechanoreceptors / C.E. Schweitzer, J.L. Johnson, C.A. Escudero, S.G. Vincent, J.T. Fisher 179

32 Pulmonary Gas Exchange in Anatomically-Based Models of the Lung / Annalisa Swan, Peter Hunter, Merryn Tawhai 184

33 Multi-scale Models of the Lung Airways and Vascular System / Merryn H. Tawhai, Kelly S. Burrowes 190

34 Modeling Structure-Function Interdependence of Pulmonary Gas Exchange / Ewald R. Weibel 195

Part VI Plasticity and Adaptation

35 Ventilatory Control during Intermittent High-Intensity Exercise in Humans / Andrew J. Cathcart, Anthony P. Turner, Christopher Butterworth, Matthew Parker, John Wilson, Susan A. Ward 203

36 Exercise-induced Respiratory Muscle Work: Effects on Blood Flow, Fatigue and Performance / J.A. Dempsey, J.D. Miller, L. Romer, M. Amann, C.A. Smith 209

37 Phase Relations Between Rhythmical Movements and Breathing in Wind Instrument Players / Dietrich Ebert, Wieland Kaerger 213

38 The Effect of Two Different Intermittent Hypoxia Protocols on Ventilatory Responses to Hypoxia and Carbon Dioxide at Rest / Michael Koehle, William Sheel, William Milsom, Donald McKenzie 218

39 Respiratory Long-Term Facilitation: Too Much or Too Little of a Good Thing? / Safraaz Mahamed, Gordon S. Mitchell 224

40 Contribution of Endothelin-1 and Endothelin A and B Receptors to the Enhanced Carotid Body Chemosensory Responses Induced by Chronic Intermittent Hypoxia / Sergio Rey, Rodrigo Del Rio, Rodrigo Iturriaga 228

41 Intermittent Hypoxia Induces Respiratory Long-Term Facilitation in Postnatal Rats / Arash Tadjalli, James Duffin, John Peever 233

42 Respiratory Control, Respiratory Sensations and Cycling Endurance After Respiratory Muscle Endurance Training / Samuel Verges, Urs Kruttli, Bernhard Stahl, Ralf Frigg, Christina M. Spengler 239

43 Non-dimensional Quantification of the Interactions Between Hypoxia, Hypercapnia and Exercise on Ventilation in Humans / H.E. Wood, M. Fatemian, P.A. Robbins 245

44 Elevated Body Temperature Exaggerates Laryngeal Chemoreflex Apnea in Decerebrate Piglets / Luxi Xia, Tracey Damon, J.C. Leiter, Donald Bartlett, Jr. 249

Part VII Neuromodulation

45 Effects of Systemic Administration of Mirtazapine on Respiratory Muscle Activity in Sleeping Rats / Y.-L. Chou, J.T. Stanley, K. Vujisic, R.B. Berry, P.W. Davenport, J.J. Anderson, L.F. Hayward 257

46 Control of Genioglossus Muscle by Sleep State-Dependent Neuromodulators / Richard L. Horner 262

47 Significance of Multiple Neurochemicals that Regulate Respiration / Paul M. Pilowsky, Qi-Jian Sun, Tina Lonergan, John M. Makeham, Maryam Seyedabadi, Todd A. Verner, Ann K. Goodchild 268

48 Disinhibition of the Dorsomedial Hypothalamus Increases the Frequency of Augmented Breaths in the Anesthetized Rat / C.R. Reynolds, K. Vujisic, P.W. Davenport, L.F. Hayward 274

49 Major Components of Endogenous Neurotransmission Underlying the Discharge Activity of Hypoglossal Motoneurons in vivo / Edward J. Zuperku, Ivo F. Brandes, Astrid G. Stucke, Antonio Sanchez, Francis A. Hopp, Eckehard A. Stuth 279

Part VIII Comparative Aspects

50 Control of Ventilation in Diving Birds / Patrick J. Butler, Lewis G. Halsey 287

51 Evolutionary Trends in Respiratory Mechanisms / William K.

Milsom 293

Part IX Central Chemosensitivity

52 A Computer Model of Mammalian Central CO[subscript 2] Chemoreception / Mykyta Chernov, Robert W. Putnam, J.C. Leiter 301

53 A Mathematical Model of pH[subscript i] Regulation in Central CO[subscript 2] - Chemoreception / Juan M. Cordovez, Chris Clausen, Leon C. Moore, Irene C. Solomon 306

54 Plasticity in the Brain: Influence of Bilateral Carotid Body Resection (bCBR) on Central CO[subscript 2] Sensitivity / Albert Dahan, Elise Sarton, Luc Teppema 312

55 Glial Modulation of CO[subscript 2] Chemosensory Excitability in the Retrotrapezoid Nucleus of Rodents / Joseph S. Erlichman, Robert W. Putnam, J.C. Leiter 317

56 The Carotid Chemoreceptors are a Major Determinant of Ventilatory CO[subscript 2] Sensitivity and of PaCO[subscript 2] During Eupneic Breathing / Hubert V. Forster, Paul Martino, Matt Hodges, Katie Krause, Josh Bonis, Suzanne Davis, L. Pan 322

57 The Retrotrapezoid Nucleus and Central Chemoreception / Patrice G. Guyenet, Douglas A. Bayliss, Daniel K. Mulkey, Ruth L. Stornetta, Thiago S. Moreira, Ana T. Takakura 327

58 The Chemosensitive Response of Neurons from the Locus Coeruleus (LC) to Hypercapnic Acidosis with Clamped Intracellular pH / Lynn K. Hartzler, Jay B. Dean, Robert W. Putnam 333

59 CO[subscript 2]-sensitivity of GABAergic Neurons in the Ventral Medullary Surface of GAD67-GFP Knock-in Neonatal Mice / Junya Kuribayashi, Shigeki Sakuraba, Yuki Hosokawa, Eiki Hatori, Miki Tsujita, Junzo Takeda, Yuchio Yanagawa, Kunihiko Obata, Shun-ichi Kuwana 338

60 Multiple Central Chemoreceptor Sites: Cell Types and Function in vivo / Gene Nattie, Aihua Li 343

61 Intrinsic Chemosensitivity of Individual Nucleus Tractus Solitarius (NTS) and Locus Coeruleus (LC) Neurons from Neonatal Rats / Nicole L. Nichols, Lynn K. Hartzler, Susan C. Conrad, Jay B. Dean, Robert W. Putnam 348

62 Chemosensitive Neuronal Network Organization in the Ventral Medulla Analyzed by Dynamic Voltage-Imaging / Yasumasa Okada, Shun-ichi Kuwana, Haruko Masumiya, Naofumi Kimura, Zibin Chen, Yoshitaka Oku 353

Part X Brainstem Mechanisms Underlying Cardio-Respiratory Control

63 The Effects of a Respiratory Acidosis on Human Heart Rate Variability / S.J. Brown, R. Howden 361

64 Neurokinin-1 Receptor Activation in the Botzinger Complex Evokes Bradypnea and is Involved in Mediating the Hering-Breuer Reflex / Angelina Y. Fong, Jeffrey T. Potts 366

65 Brainstem Catecholaminergic Neurons Modulate both Respiratory and Cardiovascular Function / Aihua Li, Laura Emond, Eugene Nattie 371

66 Responses of Brainstem Respiratory Neurons to Activation of Midbrain Periaqueductal Gray in the Rat / Hari Subramanian, Zheng-Gui Huang, Ron Balnave 377

67 Computational Model of TASK Channels and PKC-Pathway Dependent Serotonergic Modulatory Effects in Respiratory-Related Neurons / Tzu-Hsin B. Tsao, Robert J. Butera 382

68 Modulation of Hering-Breuer Reflex by Ventrolateral Pons / Hui Wang, Heng Zhang, Gang Song, Chi-Sang Poon 387

69 Respiratory Network Complexity in Neonatal Rat in vivo and in vitro / Hui Jing Yu, Xinnian Chen, Ryan M. Foglyano, Christopher G. Wilson, Irene C. Solomon 393

Part XI Multifunctional and Reconfiguring Networks

70 Fast Oscillatory Rhythms in Inspiratory Motor Discharge: A Mathematical Model / Xinnian Chen, Ki H. Chon, Irene C. Solomon 401

71 Burst-to-Burst Variability in Respiratory Timing, Inspiratory-Phase Spectral Activity, and Inspiratory Neural Network Complexity in Urethane-Anesthetized C57BL/6 Mice in vivo / Hyun Hye Chun, Evan T. Spiegel, Irene C. Solomon 407

72 Effects of Hypercapnia on Non-nutritive Swallowing in Newborn Lambs / Charles Duvareille, Nathalie Samson, Marie St-Hilaire, Philippe Micheau, Veronique Bournival, Jean-Paul Praud 413

73 CPAP Inhibits Non-nutritive Swallowing Through Stimulation of Bronchopulmonary Receptors / Nathalie Samson, Charles Duvareille, Marie St-Hilaire, Veronique Clapperton, Jean-Paul Praud 418

74 Glutamatergic Neurotransmission is Not Essential for, but Plays a Modulatory Role in, the Production of Gasping in Arterially-Perfused Adult Rat / Kelly A. Warren, Irene C. Solomon 423

Part XII Clinical Perspectives: Modeling and Control of Breathing (i.e., Sleep Apnea)

75 Potential Mechanism for Transition Between Acute Hypercapnia During Sleep to Chronic Hypercapnia During Wakefulness in Obstructive Sleep Apnea / Kenneth I. Berger, Robert G. Norman, Indu Ayappa, Beno W. Oppenheimer, David M. Rapoport, Roberta M. Goldring 431

76 Biochemical Control of Airway Motor Neurons During Rapid Eye Movement Sleep / Patricia L. Brooks, John H. Peever 437

77 Prediction of Periodic Breathing at Altitude / Keith Burgess, Katie Burgess, Prajan Subedi, Phil Ainslie, Zbigniew Topor, William Whitelaw 442

78 A Negative Interaction Between Central and Peripheral Respiratory Chemoreceptors May Underlie Sleep-Induced Respiratory Instability: A Novel Hypothesis / Trevor A. Day, Richard J.A. Wilson 447

79 Ventilatory Response to Hypercapnia in Pre-menopausal and Post-menopausal Women / Chantel T. Debert, Kojiro Ide, Marc J. Poulin 452

80 Oxidative Stress Impairs Upper Airway Muscle Endurance in an Animal Model of Sleep-Disordered Breathing / Mark Dunleavy, Aidan Bradford, Ken D. O'Halloran 458

81 Ventilatory and Blood Pressure Responses to Isocapnic Hypoxia in OSA Patients / Glen E. Foster, Patrick J. Hanly, Michele Ostrowski, Marc J. Poulin 463

82 Modeling of Sleep-Induced Changes in Airway Function: Implication for Nocturnal Worsening of Bronchial Asthma / Musa A. Haxhiu, Prabha Kc, Kannan V. Balan, Christopher G. Wilson, Richard J. Martin 469

83 The Effects of Wakefulness State on the Temporal Characteristics of Ventilatory Variables in Man / J. Ingemann Jensen, A. Varlese, S. Karan, W. Voter, L. Palmer, D.S. Ward 475

84 Cerebral Blood Flow and Ventilatory Sensitivity to CO[subscript 2] Measured with the Modified Rebreathing Method / Jaideep J. Pandit, Ravi M. Mohan, Nicole D. Paterson, M.J. Poulin 480

85 Naloxone Reversal of Opioid-Induced Respiratory Depression with Special Emphasis on the Partial Agonist/Antagonist Buprenorphine / Elise Sarton, Luc Teppema, Albert Dahan 486

86 The Pulse Oxygen Saturation: Inspired Oxygen Pressure (SpO[subscript 2]:P[subscript I]O[subscript 2]) Diagram: Application in the Ambulatory Assessment of Pulmonary Vascular Disease / Neil M. Skjodt, Christian Ritz, Dilini Vethanayagam 492

87 Hypocapnia and Airway Resistance in Normal Humans / Craig D. Steinback, William A. Whitelaw, Marc J. Poulin 497

88 Disturbances of Breathing in Rett Syndrome: Results from Patients and Animal Models / Georg M. Stettner, Peter Huppke, Jutta Gartner, Diethelm W. Richter, Mathias Dutschmann 503

89 NHE3 in the Human Brainstem: Implication for the Pathogenesis of the Sudden Infant Death Syndrome (SIDS)? / Martin Wiemann, Stilla Frede, Frank Tschentscher, Heidrun Kiwull-Schone, Peter Kiwull, Dieter Bingmann, Bernd Brinkmann, Thomas Bajanowski|p508

90 The Ventilatory Response to Exercise Does Not Differ Between Obese Women With and Without Dyspnea on Exertion / Helen E. Wood, Trisha L. Semon, Laurie A. Comeau, Belinda Schwartz, Rebecca M. MacDougall, Marilyn N. Klocko, Tony G. Babb 514.

Notes:

Proceedings of the Oxford Conference held from 19-24 Sept. 2006, Lake Louise, Alberta.

Includes bibliographical references and indexes.

ISBN:

9780387736921

0387736921

OCLC:

166386568