Hereditary breast cancer / edited by Claudine Isaacs, Timothy R. Rebbeck.

Format:

Book

Contributor:

Isaacs, Claudine.

Rebbeck, Timothy R.

Language:

English

Subjects (All):

Breast--Cancer--Genetic aspects.

Breast.

Breast Neoplasms--genetics.

Genetic Predisposition to Disease.

Genetic Testing.

Medical Subjects:

Breast Neoplasms--genetics.

Genetic Predisposition to Disease.

Genetic Testing.

Physical Description:

xiii, 384 pages : illustrations ; 26 cm

Place of Publication:

New York : Informa Healthcare, [2008]

Summary:

Intended for medical oncologists, surgeons, obstetricians, gynecologists, geneticists, genetic counselors, and primary care physicians, this text presents the epidemiological, biological, and clinical issues associated with hereditary breast cancer. It offers clear guidance on the application and utilization of cancer risk assessment models, genetic counseling and testing of high risk patients, and screening and prevention options for individuals at risk of hereditary breast cancer. Addressing every essential aspect of hereditary breast cancer, this source offers comprehensive analyses of hereditary breast cancer-associated syndromes, low penetrance genes, and hereditary breast cancer-associated with mutations in the BRCA1 and BRCA2 genes. Hereditary Breast Cancer provides an overview of clinical, basic, and epidemiological aspects of hereditary breast cancer, and discusses the advancements and changes in this rapidly evolving field...gives an in-depth analysis of hereditary breast cancer-associated syndromes...explores ethical and practical issues in genetic counseling and testing...reviews treatment, screening, and preventative measures.

Contents:

The genetic epidemiology of hereditary breast cancer / Douglas F. Easton, Antonis C. Antoniou, and Deborah Thompson

Risk prediction in breast cancer / Lisa Walker and Rosalind Eeles

Bioethics of genetic testing for hereditary breast cancer / Beth N. Peshkin and Wylie Burke

Cancer risks in BRCA1 and BRCA2 mutation carriers / Kenneth Offit and Peter Thom

PTEN and Cowden syndrome / Kevin M. Zbuk, Jennifer Stein, and Charis Eng

Li-Fraumeni syndrome / Louise C. Strong

Rare causes of inherited breast cancer susceptibility / Katherine L. Nathanson

Low-penetrance genes in breast cancer / Paul D.P. Pharoah

Biology of BRCA1- and BRCA2-associated carcinogenesis / Jenny Llamas and Lawrence C. Brody

Genetic testing and counseling issues / Jill Stopfer, Vickie Venne, and Katherine Schneider

Molecular diagnostics: methods and limitations / Sean V. Tavtigian and Florence LeCalvez-Kelm

Breast cancer risk modifiers / Roger Milne and Georgia Chenevix-Trench

BRCA1 and BRCA2 in underserved and special populations / Bifeng Zhang and Olufunmilayo I. Olopade

Psychological and behavioral impact of BRCA1/2 genetic testing / Kristi Graves and Marc D. Schwartz

Breast cancer screening and prevention options in BRCA1 and BRCA2 mutation carriers / Karen Lisa Smith and Claudine Isaacs

Ovarian cancer screening and prevention options: ovarian cancer screening and its limitations. Who should be screened? / Karen H. Lu and Steven J. Skates

Management of BRCA-negative hereditary breast cancer families / Noah D. Kauff

Pathology of breast tumors in hereditary breast cancer / William D. Foulkes and Lars A. Akslen

Pathology of ovarian tumors in mutation carriers / Frédérique Penault-Llorca and Sunil R. Lakhani

Local treatment issues in women with hereditary breast cancer / Merav A. Ben-David and Lori J. Pierce

Systemic therapy for BRCA-associated breast cancer / Mark Robson.

Notes:

Includes bibliographical references and index.

ISBN:

0849390222

9780849390227

OCLC:

134990775

Online:

Publisher description