Immune dysfunction and immunotherapy in heart disease / edited by Ronald Ross Watson, Douglas F. Larson.

Format:

Book

Contributor:

Watson, Ronald R. (Ronald Ross)

Larson, Douglas F.

Language:

English

Subjects (All):

Heart--Diseases--Immunological aspects.

Heart.

Heart--Diseases--Immunotherapy.

Immunologic diseases--Complications.

Immunologic diseases.

Heart Diseases--immunology.

Heart Diseases--therapy.

Immune System Diseases--complications.

Immune System Diseases--therapy.

Immunotherapy--methods.

Heart--Diseases.

Medical Subjects:

Heart Diseases--immunology.

Heart Diseases--therapy.

Immune System Diseases--complications.

Immune System Diseases--therapy.

Immunotherapy--methods.

Physical Description:

xiv, 308 pages : illustrations ; 27 cm

Place of Publication:

Malden, Mass. ; Oxford : Blackwell Futura, 2007.

Summary:

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction. The outstanding editor team of two internationally recognized immunologists - Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.

The four parts of the book address: Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes, Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs, Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs, Immune Dysfunction Leading to Heart Disease: Induction by Pathogens. Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Contents:

Part I Immune dysfunction leading to heart disease: induction by physiological changes 1

1 Immunosuppression by ultraviolet light-B radiation: a mediator of cardiac remodeling / Sherma Zibadi, Douglas F. Larson, Ronald Ross Watson 3

2 Immune mechanisms in pediatric cardiovascular disease / Wendy A. Luce, Mandar S. Joshi, Timothy M. Hoffman, Timothy F. Feltes, John Anthony Bauer 6

3 Heart failure-role of autoimmunity / Urs Eriksson 17

4 Immune basis of hypertension in humans / Katherine Horak, Douglas F. Larson 28

5 Immune dysregulation: potential mediator of metabolic syndrome-induced cardiac remodeling / Sherma Zibadi, Douglas F. Larson, Ronald Ross Watson 34

6 T helper 2 cell cytokines in remodeling of aortic wall / W. L Chan 39

7 Effects of TNF-[alpha] on cardiac function / Bo Yang, Douglas F. Larson 48

8 Immunosuppression in promotion of cardiac allograft vasculopathy / Farzad Moien-Afshari, Jonathan Choy, Bruce M. McManus, Ismail Laher 57

9 Immunotherapy for left ventricular dysfunction after heart transplantation / Charles E. Canter 80

Part II Immune dysfunction promoting CVD: induction by transplantation drugs 95

10 Immunomodulating therapy in chronic heart failure / Lars Gullestad, Jan Kristian Damas, Arne Yndestad, Pal Aukrust 97

11 Statins in atherosclerosis: role of immune regulation / Claire Arnaud, Francois Mach 109

12 ACE inhibitors as immunomodulators: treatment of cardiovascular disease / Christina Grothusen, Bernhard Schieffer 116

13 Treatment of heart failure by anticytokine therapies / Donna L. Vredevoe, Julia R. Gage 128

Part III Immune dysfunction leading to heart dysfunction: induction or prevention by cardiotherapeutic drugs 133

14 Pathogenesis of cardiovascular complications in the acquired immunodeficiency syndrome / Giuseppe Barbaro 135

15 Cytokines and T cell-mediated responses in autoimmune myocarditis / Jin Zhang 152

16 Drugs of abuse: accentuation of immunomodulation of viral myocarditis / Oana Madalina Petrescu, James P. Morgan 157

Part IV Immune dysfunction leading to heart disease: induction by pathogens 173

17 Osteopontin: the link between the immune system and cardiac remodeling / Samira Najmaii, Qianli Yu, Douglas F. Larson 175

18 Inflammatory immune activation in heart failure patients: therapeutic implications / Mohammad Abraham Kazemizadeh Gol, Mohsen Araghi-Niknam 182

19 Role of innate immune dysregulation in diabetic heart failure / Betsy B. Dokken, Paul F. McDonagh 186

20 Tolerance in heart transplantation: current and future role / Kimberly Gandy, Jos Domen, Jack Copeland 195

21 Neutralization of Th2 cytokines in therapy of cardiovascular pathology / A. Mandel, A. E. Bolton 207

22 Anti-inflammatory immune therapy in heart disease / David Chen, Christian Assad-Kottner, Francisco J. Cordova, Carlos Orrego, Guillermo Torre-Amione 217

23 Cholesterol, interleukin-6 inflammation, and atherosclerosis-role of statins, bisphosphonates, and plant polyphenols in atherosclerosis and other diseases of aging / Sota Omoigui 227

24 Autoimmune myocarditis: treatment with anti-T-cell antibodies / Zofia T. Bilinska, Witold Ruzytto 256

25 Immunosuppressive therapy to counter cardiac allograft vasculopathy / Carl V. Leier 263

26 Role of oral pathogens in the pathogenesis of coronary heart disease / Palle Holmstrup 271

27 Myocardial regenerative potential by stem cell transplant / Yinhong Chen, Catherine A. Priest, Joseph D. Gold 280

28 Bioflavanoids and dietary anti-inflammatory actions: role in cardiovascular diseases / Simin Bolourchi-Vaghefi, Amy Galena 288.

Notes:

Includes bibliographical references and index.

ISBN:

140515568X

9781405155687

OCLC:

83758658

Online:

Contributor biographical information

Publisher description