Targeted therapies in oncology / edited by Giuseppe Giaccone, Jean-Charles Soria.

Format:

Book

Contributor:

Giaccone, Giuseppe.

Soria, Jean-Charles.

Language:

English

Subjects (All):

Cancer--Treatment.

Cancer.

Neoplasms--therapy.

Genetic Therapy.

Immunotherapy.

Medical Subjects:

Neoplasms--therapy.

Genetic Therapy.

Immunotherapy.

Physical Description:

ix, 412 pages : illustrations ; 24 cm

Place of Publication:

New York : Informa Healthcare, [2007]

Summary:

Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere interacting agents, apoptosis inducers, and anti-invasive agents. This book presents an authoritative overview of existing molecular targeted therapies, their relevance and role for specific tumors, and their clinical efficacy and impact on patient treatment.

Responding to the expanding array of targeted agents currently under clinical development, this source covers a broad array of innovative anticancer agents with a well-defined molecular target, including the most promising ones in preclinical and clinical development...supplies a current overview of the different therapeutic classes of existing targeted agents and explains their relevance and impact upon specific tumors... contains the most recent findings regarding the clinical activity and therapeutic spectrum of targeted compounds...analyzes the response rates, stabilization, and clinical benefits of specific molecular targeting...and identifies research pathways that may impact the future of cancer therapy, as well as an expert discussion of recent clinical trial results.

Contents:

Overview of existing therapies / Giannis Mountzios and Jean-Charles Soria

Signal transduction inhibitors, HER family, EGFR inhibition, and clinical achievements / Giuseppe Giaccone and Paolo Zucali

HER2 inhibition and clinical achievements / Toru Mukohara and Pasi A. Jänne

Pan-HER inhibitors / Gérard Milano

Inhibiting the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway / Janet E. Dancey

Farnesyl transferase inhibitors in cancer: promise, but limited proof / Laura Fanucchi, Michael P. Fanucchi, and Fadlo R. Khuri

Protein Kinase C inhibitors in the treatment of non-small cell lung cancer / Yun Oh ... [et al.]

Signal transduction inhibitors: PDGFR and c-KIT inhibitors / Jean-Yves Blay ... [et al.]

The insulin-like growth factor 1 receptor: a target for cancer treatment / Yungan Tao, Jean Bourhis, and Eric Deutsch

Aurora kinase inhibitors / Mitesh J. Borad, Steven L. Warner, and Daniel D. von Hoff

Apoptosis modulators: p53 targeting / Sunil Chada ... [et al.]

Survivin / Dario C. Altieri

TRAIL modulators / C.H. Mom ... [et al.]

VEGF targeting / Lee M. Ellis

Targeting angiogenesis with oral agents / Benjamin Besse and Jean-Pierre Armand

Endothelial cell propagation targeting / Gordon C. Tucker

HIF-1 inhibitors / Giovanni Melillo

Antivascular agents / Jane Robertson

Matrix metalloproteinases / Stéphane Vignot and Jean-Philippe Sapno

Src inhibitors / Francisco Cruzalegui

Telomerase and Telomere interacting agents / Jean-Franc̦ois Riou ... [et al.]

Targeting Hsp90: the cancer super-chaperone / Paul Workman and Swee Sharp.

Notes:

Includes bibliographical references and index.

ISBN:

084939371X

9780849393716

OCLC:

137295017

Online:

Publisher description