Combating the threat of pandemic influenza : drug discovery approaches / edited by Paul F. Torrence.

Format:

Book

Contributor:

Torrence, Paul F.

Language:

English

Subjects (All):

Antiviral agents.

Influenza--Chemotherapy.

Influenza.

Influenza, Human--drug therapy.

Influenza, Human--prevention & control.

Antiviral Agents--therapeutic use.

Disease Outbreaks--prevention & control.

Drug Design.

Influenza Vaccines--therapeutic use.

Chemotherapy.

Medical Subjects:

Influenza, Human--drug therapy.

Influenza, Human--prevention & control.

Antiviral Agents--therapeutic use.

Disease Outbreaks--prevention & control.

Drug Design.

Influenza Vaccines--therapeutic use.

Physical Description:

xiii, 279 pages, 12 unnumbered pages of plates : illustrations (some color) ; 25 cm

Place of Publication:

Hoboken, N.J. : Wiley-Interscience, [2007]

Summary:

Priorities for combating pandemic influenza include rapid detection and identification, the quick administration of available drugs to treat the infection, the development of new antivirals, and the development of vaccines. Since lead-time may be required to produce an effective vaccine, antivirals would serve as a key first line of defense in containing an outbreak. Diverse antivirals, acting through different mechanisms, would help stay the development of resistant viruses. Thus, drug discovery for influenza antivirals is an important public health-related endeavor.

With chapters contributed by leading international specialists, this guide gets readers up to speed on the latest advances and technologies in diverse approaches to drug discovery, covering: Existing antivirals, including broadly effective anti-respiratory virus agents, The development of high-throughput screening assays, IFN resistance, The development of nucleic acid-based antiviral drugs, Antiviral RNAi strategies targeting influenza virus, Other promising antiviral drug discovery strategies. Combating the Threat of Pandemic Influenza: Drug Discovery Approaches consolidates the latest information on diverse approaches into one comprehensive resource. It is an invaluable, hands-on reference for researchers in medicinal chemistry, pharmaceutical-chemistry, drug discovery, biochemistry, virology, microbiology, and public health.

Contents:

Existing influenza antivirals: their mechanisms of action and potential in the face of avial influenza / Erik De Clercq

Development of high-throughput screening assays for influenza / Diana L. Noah, E. Lucile White, and James W. Noah

Mechanisms of IFN resistance by influenza virus / Heather J. Ezelle and Bret A. Hassel

Broadly effective anti-respiratory virus agents / Shiro Shigeta

Current status on development of nucleic acid-based antiviral drugs against influenza virus infection / Jonathan P. Wong ... [et al.]

Antiviral RNA interference strategies targeting influenza virus and other respiratory viruses / Joost Haasnoot and Ben Berkhout

Promising antiviral glyco-molecules from an edible algae / Toshimitsu Hayashi ... [et al.]

Rational design of an anti-adhesion drug for influenza / Nicolai V. Bovin and Alexandra S. Gambaryan

Understanding influenza neuraminidase inhibitors using quantitative structure-activity relationship (QSAR) models / Rajeshwar P. Verma and Corwin Hansch

Peptide inhibitors targeting virus-cell fusion in Class 1 enveloped viruses / George F. Gao

Novel influenza therapeutics / Laura M. Aschenbrenner ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

0470118792

9780470118795

OCLC:

86113115

Online:

Contributor biographical information

Publisher description