Sample size calculations in clinical research / [edited by] Shein-Chung Chow, Jun Shao, Hansheng Wan.

Format:

Book

Contributor:

Chow, Shein-Chung, 1955-

Shao, Jun (Statistician)

Wang, Hansheng, 1977-

Series:

Chapman & Hall/CRC biostatistics series ; 20.

Chapman & Hall/CRC biostatistics series ; 20

Language:

English

Subjects (All):

Clinical medicine--Research--Statistical methods.

Clinical medicine.

Drug development--Statistical methods.

Drug development.

Sampling (Statistics).

Sample Size.

Biometry--methods.

Clinical medicine--Research.

Medical Subjects:

Sample Size.

Biometry--methods.

Physical Description:

xiv, 465 pages : illustrations ; 25 cm.

Edition:

Second edition.

Place of Publication:

Boca Raton : Chapman & Hall/CRC, [2008]

Summary:

This book explains how the formulas and procedures for sample size calculations can be used in a variety of clinical research and development stages. It presents real-world examples from several therapeutic areas to illustrate clinical and statistical concepts, interpretations, and interactions. The book also explores emerging topics in pharmaceutical research and development, including QT/QTc studies with time-dependent replicates and the use of propensity score analysis in nonrandomized or observational studies. This edition now provides sample size calculations for three major areas of clinical research: dose response studies, microarray studies, and Bayesian approaches.

Contents:

Considerations prior to sample size calculation

Comparing means

Large sample tests for proportions

Exact tests for proportions

Tests for goodness-of-fit and contingency tables

Comparing time-to-event data

Group sequential methods

Comparing variabilities

Bioequivalence testing

Dose response studies

Microarray studies

Bayesian sample size calculation

Nonparametrics

Sample size calculation in other areas.

Notes:

Includes bibliographical references (pages 427-449) and index.

ISBN:

1584889829

9781584889823

OCLC:

85862292