Mitochondria : the dynamic organelle / edited by Stephen W. Schaffer and M-Saadeh Suleiman.

Format:

Book

Contributor:

Schaffer, S. W.

Suleiman, M.-Saadeh.

Series:

Advances in biochemistry in health and disease ; v. 2.

Advances in biochemistry in health and disease ; v. 2

Language:

English

Subjects (All):

Mitochondria.

Mitochondrial pathology.

Mitochondrial Diseases.

Medical Subjects:

Mitochondria.

Mitochondrial Diseases.

Physical Description:

x, 359 pages, iv pages of plates : illustrations (partly color) ; 25 cm.

Place of Publication:

New York : Springer, [2007]

Summary:

Mitochondria: The Dynamic Organelle focuses on the function of the mitochondria and the organelle's role in cellular pathology. While the traditional function of the mitochondria is metabolic, recent cutting-edge studies have uncovered a central role for mitochondria in cell signaling, cell survival, and cell death. Mitochondria: The Dynamic Organelle presents examples of crosstalk between the mitochondria and the rest of the cell, which serve a regulatory role by modulating the levels of key metabolites, ions, and oxidants, or the activities of key rate-controlling enzymes. Detailed descriptions of the involvement of membrane receptors, channels, enzymes, and metabolites in the cardioprotective mechanisms of the mitochondria are provided. This volume also discusses the death pathways that are initiated by the mitochondria. Novel therapeutic interventions are proposed which interfere with the death cascades, thereby rescuing the cell from mitochondria-linked apoptosis and necrotic oncosis.

Mitochondria: The Dynamic Organelle is a timely contribution that addresses the reemergence of the mitochondria as a key player in cellular function and pathology. Key topics: Amino acid metabolism, Carbohydrate and lipid metabolism, Citric acid cycle regulation and metabolite transport, Electron transport and oxidative phosphorylation, Ischemic preconditioning, Mitochondrial apoptosis, Mitochondrial DNA damage, Mitochondrial permeability transition, Mitochondrial ion transporters, Necrotic oncosis and mitochondrial dysfunction, Peroxisome proliferators-activated receptors (PPARs). Mitochondria: The Dynamic Organelle is essential reading for researchers, molecular and cellular biologists, biochemists, physiologists, and pathologists.

Contents:

Part 1 Mitochondrial Metabolism

1 Regulation of Mitochondrial Respiration in Heart Muscle / Ilmo Hassinen 3

2 Regulation of Fatty Acid Oxidation of the Heart / Clifford D. L. Folmes, Gary D. Lopaschuk 27

3 Regulation of Mitochondrial Fuel Handling by the Peroxisome Proliferator-Activated Receptors / Mary C. Sugden, Mark J. Holness 63

4 Molecular Structure of the Mitochondrial Citrate Transport Protein / Ronald S. Kaplan, June A. Mayor 97

5 Regulation of Pyruvate and Amino Acid Metabolism / Thomas C. Vary, Wiley W. Souba, Cristopher J. Lynch 117

6 Amino Acids and the Mitochondria / Nicola King 151

Part 2 The Dynamic Nature of the Mitochondria

7 Mechanotransduction of Shear-Stress at the Mitochondria / Abu-Bakr Al-Mehdi 169

Part 3 Mitochondria as Initiators of Cell Signaling

8 Formation of Reactive Oxygen Species in Mitochondria / Julio F. Turrens 185

9 Mitochondrial Calcium: Role in the Normal and Ischaemic/ Reperfused Myocardium / Elinor J. Griffiths, Christopher J. Bell, Dirki Balaska, Guy A. Rutter 197

10 Mitochondrial Ion Channels / Brian O'Rourke 221

Part 4 Mitochondria as Initiators of Cell Death

11 The Mitochondrial Permeability Transition Pore - from Molecular Mechanism to Reperfusion Injury and Cardioprotection / Andrew P. Halestrap, Samantha J. Clarke, Igor Khalilin 241

12 The Apoptotic Mitochondrial Pathway - Modulators, Interventions and Clinical Implications / M-Saadeh Suleiman, Stephen W. Schaffer 271

13 The Role of Mitochondria in Necrosis Following Myocardial Ischemia-Reperfusion / Elizabeth Murphy, Charles Steenbergen 291

Part 5 Mitochondria as Modulators of Cell Death

14 Mitochondria and Their Role in Ischemia/Reperfusion Injury / Sebastian Phillip, James M. Downey, Michael V. Cohen 305

15 Mitochondrial DNA Damage and Repair / Inna N. Shokolenko, Susan P. Ledoux, Glenn L. Wilson 323.

Notes:

Includes bibliographical references and index.

ISBN:

0387699449

9780387699448

0387699457

9780387699455

OCLC:

184962941