Enzyme-mediated resistance to antibiotics : mechanisms, dissemination, and prospects for inhibition / editors, Robert A. Bonomo, Marcelo Tolmasky.

Format:

Book

Contributor:

Bonomo, Robert A.

Tolmasky, Marcelo.

Language:

English

Subjects (All):

Drug resistance in microorganisms.

Drug resistance in microorganisms--Genetic aspects.

Microbial enzymes.

Anti-Bacterial Agents.

Drug Resistance, Bacterial.

Enzyme Inhibitors.

beta-Lactamase Inhibitors.

Medical Subjects:

Anti-Bacterial Agents.

Drug Resistance, Bacterial.

Enzyme Inhibitors.

beta-Lactamase Inhibitors.

Physical Description:

xviii, 357 pages, 8 unnumbered pages of plates : illustrations (partly color) ; 29 cm

Place of Publication:

Washington, D.C. : ASM Press, [2007]

Contents:

Overview of aminoglycosides and enzyme-mediated bacterial resistance: clinical implications / Robert A. Bonomo

Aminoglycoside antibiotics / Kanchana Majumder ... [et al.]

Structural aspects of aminoglycoside-modifying enzymes / Gerard D. Wright and Albert M. Berghuis

Aminoglycoside-modifying enzymes: characteristics, localization, and dissemination / Marcelo E. Tolmasky

rRNA methylases and resistance to macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone (MLSKO) antibiotics / Marilyn C. Roberts

β-lactamases: historical perspectives / Karen Bush and Patricia A. Bradford

Resistance mediated by penicillin-binding proteins / Malcolm G.P. Page

Inhibition of class A β-lactamases / Samy O. Meroueh, Jooyoung Cha, and Shahriar Mobashery

Class B β-lactamases / Gian Maria Rossolini and Jean-Denis Docquier

Crystal structures of class C β-lactamases: mechanistic implications and perspectives in drug design / C. Bauvois and J. Wouters

Class D β-lactamases / Franck Danel, Malcolm G.P. Page, and David M. Livermore

Kinetics of β-lactamases and penicillin-binding proteins / Moreno Galleni and Jean-Marie Frère

The pharmaceutical industry and inhibitors of bacterial enzymes: implications for drug development / David M. Shlaes, Lefa Alksne, and Steven J. Projan

β-lactamase inhibitory proteins / Zhen Zhang and Timothy Palzkill

Active drug efflux in bacteria / Jürg Dreier

Overview of dissemination mechanisms of genes coding for resistance to antibiotics / Marcelo E. Tolmasky

Conjugative transposons / Louis B. Rice

The dissemination of antibiotic resistance by bacterial conjugation / Virginia L. Waters

Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics / Juan C. Alonso ... [et al.]

Integrons and superintegrons / Robert A. Bonomo, Andrea M. Hujer, and Kristine M. Hujer

The biological cost of antibiotic resistance / Dan I. Andersson ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

1555813038

9781555813031

OCLC:

80019936