Linkage disequilibrium and association mapping : analysis and applications / edited by Andrew R. Collins.

Format:

Book

Contributor:

Collins, A. (Andrew)

Series:

Methods in molecular biology (Clifton, N.J.) ; v. 376.

Methods in molecular biology ; 376

Language:

English

Subjects (All):

Genomics--Statistical methods.

Genomics.

Gene mapping.

Linkage Disequilibrium.

Chromosome Mapping.

Medical Subjects:

Linkage Disequilibrium.

Chromosome Mapping.

Physical Description:

xiv, 255 pages : illustrations ; 24 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2007]

Summary:

As researchers continue to make enormous progress in mapping disease genes, exciting, novel, and complex analysis have emerged. In Linkage Disequilibrium and Association Mapping: Analysis and Applications, scientists from around the world, who are leaders in this field, contribute their vast experience and expertise to produce a comprehensive and fascinating text for researchers and clinicians alike.

The volume comprises four general sections: the first presents an overview and historical basis of the subject. The second section considers the developing methodology and recent findings from studies which have characterized the genome-wide linkage disequilibrium structure in enormous detail. The following section examines all aspects of disease association mapping methodology, and the final two chapters review the early successes in mapping genes involved in two of the most important human diseases: asthma and type 2 diabetes.

Features

Chapters written by world-renowned leaders in the field of gene-mapping

A clear synthesis of all important methodology that has been developed in this complex research field

Cutting-edge analysis of the most up-to-date and preeminent information available

Contents:

1 Linkage Disequilibrium and Association Mapping: An Introduction / Andrew R. Collins 1

2 A History of Association Mapping / Newton E. Morton 17

3 Linkage Disequilibrium Maps and Location Databases / William Tapper 23

4 LDMAP: The Construction of High-Resolution Linkage Disequilibrium Maps of the Human Genome / Tai-Yue Kuo, Winston Lau, Andrew R. Collins 47

5 Linkage Disequilibrium as a Tool for Detecting Signatures of Natural Selection / Sarah Ennis 59

6 The Genetic Basis of Complex Traits: Rare Variants or "Common Gene, Common Disease"? / Sudha K. Iyengar, Robert C. Elston 71

7 Linkage Disequilibrium Mapping for Complex Disease Genes / Andrew DeWan, Robert J. Klein, Josephine Hoh 85

8 Linkage Disequilibrium Maps and Disease-Association Mapping / Nikolas Maniatis 109

9 Coalescent Methods for Fine-Scale Disease-Gene MappingAndrew P. Morris 123

10 Family-Based Linkage Disequilibrium Tests Using General Pedigrees / Yin Yao Shugart, Lina Chen, Rui Li, Terri Beaty 141

11 Association Studies Using Familial Cases: An Efficient Strategy for Identifying Low-Penetrance Disease Alleles / Emily L. Webb, Richard S. Houlston 151

12 Association Mapping Using Pooled DNA / Hsin-Chou Yang, Cathy S. J. Fann 161

13 Selecting Single-Nucleotide Polymorphisms for Association Studies With SNPbrowser Software / Francisco M. De La Vega 177

14 Avoiding False Discoveries in Association Studies / Chiara Sabatti 195

15 Gene Mapping in Asthma-Related Traits / Tarja Laitinen 213

16 Identifying Susceptibility Variants for Type 2 Diabetes / Eleftheria Zeggini, Mark I. McCarthy 235.

Notes:

Includes bibliographical references and index.

ISBN:

1588296695

9781588296696

1597453897

9781597453899

OCLC:

68705633