Cancer metastasis and the lymphovascular system : basis for rational therapy / edited by Stanley P.L. Leong.

Format:

Book

Contributor:

Leong, Stanley P. L.

Series:

Cancer treatment and research ; 135.

Cancer treatment and research ; 135

Language:

English

Subjects (All):

Lymphatic metastasis.

Lymphatic Metastasis--physiopathology.

Neoplasm Metastasis--physiopathology.

Lymphatic System--physiology.

Neoplasms--therapy.

Medical Subjects:

Lymphatic Metastasis--physiopathology.

Neoplasm Metastasis--physiopathology.

Lymphatic System--physiology.

Neoplasms--therapy.

Physical Description:

xiv, 309 pages : illustrations ; 25 cm.

Place of Publication:

New York ; London : Springer, 2007.

Summary:

Sentinel lymph node procedures have opened a window of opportunity for the study of micrometastasis. In eighty percent (80%) of metastasis there lies an orderly pattern of progression via the lymphatic network, while 20% of the time systemic metastasis occurs, bypassing the lymphatic system. During the past two decades, significant progress has been achieved in understanding the anatomical, functional, cellular and molecular aspects of the lymphovascular system and the metastasis process. Molecular imaging advances help to localize early cancers more precisely. Current status of the immune responses in the draining lymph nodes against cancer is summarized. New paradigms of early cancer growth, proliferation, and overcoming apoptosis are exploited in the development of anticancer treatment. In this book, basic scientists and clinicians exchange ideas so that laboratory findings can be applied to clinical dilemmas, and clinical problems can be targeted for research in the laboratory.

Contents:

1 Landmarks and Advances in Translational Lymphology / Marlys H. Witte, Kimberly Jones, Michael Bernas, Charles L. Witte 1

2 Embryonic Development of the Lymphovascular System and Tumor Lymphangiogenesis / Jorg Wilting, Maria Papoutsi, Kerstin Buttler, Jurgen Becker 17

3 Lymphatic Origin from Embryonic Stem Cells / Michael Dictor, Sofia Mebrahtu, Manuel Selg, Zerina Lokmic, Lydia Sorokin 25

4 Lymphatic Markers, Tumour Lymphangiogenesis and Lymph Node Metastasis / David G. Jackson 39

5 Anatomy of the Human Lymphatic System / Mauro Andrade, Alfredo Jacomo 55

6 SPECT-CT Fusion Imaging Radionuclide Lymphoscintigraphy: Potential for Limb Lymphedema Assessment and Sentinel Node Detection in Breast Cancer / A. P. Pecking, M. Wartski, R. V. Cluzan, D. Bellet, J. L. Alberini 79

7 Sentinel Node Identification using Radionuclides in Melanoma and Breast Cancer / Edwin C. Glass 85

8 Targeted Introduction of Substances into the Lymph Nodes for Endolymphatic Therapy / Peter Hirnle 101

9 Mechanisms of Metastasis: Seed and Soil / Adriano Piris, Martin C. Mihm, Jr. 119

10 Preclinical Models of Regional Lymph Node Tumor Metastasis / S. David Nathanson 129

11 A New Breast Cancer Model for Lymphatic Metastasis / Michael M. Lizardo, Ian C. MacDonald, Alan B. Tuck, Ann F. Chambers 157

12 Lymph Node Micrometastases in Lung Cancer / Katharina E. Effenberger, Wulf Sienel, Klaus Pantel 167

13 Effects of Chemokines on Tumor Metastasis / Hiroya Takeuchi, Minoru Kitago, Dave S. B. Hoon 177

14 Regional Lymph Node Metastases, a Singular Manifestation of the Process of Clinical Metastases in Cancer: Contemporary Animal Research and Clinical Reports Suggest Unifying Concepts / Blake Cady 185

15 Patterns of Metastatsis in Head and Neck Cancer / Jochen A. Werner 203

16 Patterns of Metastasis in Human Solid Cancers / Stanley P. L. Leong, Blake Cady, David M. Jablons, Julio Garcia-Aguilar, Douglas Reintgen, J. A. Werner, Yuko Kitagawa 209

17 Significance of Regional Draining Lymph Nodes in the Development of Tumor Immunity: Implications for Cancer Immunotherapy / Rongxiu Zheng, Jorgen Kjaergaard, Walter T. Lee, Peter A. Cohen, Suyu Shu 223

18 Targeting Small Molecules in Cancer / Harold J. Wanebo, David Berz, Anthony Mega 239

19 Update on the Role of EGFR Inhibitors in Cancer Therapeutics / Michalis V. Karamouzis, Athanassios Argiris 257

20 New Promises in the Adjuvant, and Palliative Treatment of Melanoma / Axel Hauschild, Dirk Schadendorf, Claus Garbe, Selma Ugurel, Katharina C. Kahler 277

21 Future Perspectives and Unanswered Questions on Cancer Metastasis and the Lymphovascular System / Stanley P. L. Leong, Marlys H. Witte 293.

Notes:

Includes bibliographical references and index.

ISBN:

9780387692180

0387692185

OCLC:

77256616