Animal models of diabetes : frontiers in research / edited by Eleazar Shafrir.

Format:

Book

Contributor:

Shafrir, Eleazar.

Language:

English

Subjects (All):

Diabetes--Animal models.

Diabetes.

Diabetes Mellitus.

Disease Models, Animal.

Medical Subjects:

Diabetes Mellitus.

Disease Models, Animal.

Physical Description:

365 pages, 2 unnumbered pages of plates : illustrations (partly color) ; 25 cm

Edition:

Second edition.

Place of Publication:

Boca Raton : CRC Press, [2007]

Summary:

As the incidence of diabetes increases worldwide, the need for recommendations on how to prevent and treat the condition grows exponentially, and so does the need for an authoritative source for information on the appropriate models to study the condition. The new edition of Animal Models of Diabetes is that source. The book presents updated and expanded information regarding the use of models in experiments with both Type 1 and Type 2 diabetes.

The new edition compiles relevant time-saving information on well-recognized models, including various mice, rats, minipigs, and Rhesus monkeys, and provides extensive references for more in-depth study. It contains new and updated referenced reviews on animals with induced obesity as well as observations on retinopathy in spontaneous diabetes resembling human lesions. The book discusses nutritionally diabetes-prone animals and considerations of insulin resistance and obesity. The contributors also address the importance of recent findings on the pathogenesis of diabetes and its complications in relation to human disease.

Including contributions from prominent experts in the field, the book brings together scattered data and lucidly presents it. This promotes the understanding of the etiopathology of diabetes and offers a new grasp of the insulin action, its negative feedback leading to insulin resistance, and its detrimental outcomes. The book also includes new information on specific complications of diabetes, offering an incentive to test advanced modalities to prevent and inhibit their occurrence.

Contents:

Rat models of type 1 diabetes: genetics, environment, and autoimmunity / John P. Mordes ... [et al.]

The NOD mouse and its related strains / Hidenori Taniguchi, Susumu Makino, and Hiroshi Ikegami

Obesity/diabetes in mice with mutations in leptin or leptin receptor genes / Streamson Chua, Jr., Lieselotte Herberg, and Edward H. Leiter

The Zucker diabetic fatty (ZDF) rat: lessons from a leptin receptor defect diabetic model / Richard G. Peterson

The Goto-Kakizaki rat / Claes-Göram Östenson

The New Zealand obese mouse: polygenic model of obesity, glucose intolerance, and the metabolic syndrome / Barbara C. Fam and Sofianos Andrikopoulos

The JCR:LA-cp rat: animal model of the metabolic syndrome exhibiting micro- and macrovascular disease / James C. Russell, Sandra E. Kelly, and Spencer D. Proctor

The SHROB (Koletsky) rat as a model for metabolic syndrome / Richard J. Koletsky, Rodney A. Velliquette, and Paul Ernsberger

OLETF rats: model for the metabolic syndrome and diabetic nephropathy in humans / Kazuya Kawano

Neonatally streptozotocin-induced (n-STZ) diabetic rats: a family of type 2 diabetes models / B. Portha ... [et al.]

The Rhesus monkey (Macaca mulatta) manifests all features of human type 2 diabetes / Barbara C. Hansen and Xenia T. Tigno

Pigs in diabetes research with special focus on type 2 diabetes research / Marianne O. Larsen and Bidda Rolin

Psammomys obesus: nutritionally induced insulin resistance, diabetes and beta cell loss / Ehud Ziv, Rony Kalman, and Eleazar Shafrir

The spontaneously diabetic Torii (SDT) rat with retinopathy lesions resembling those of humans / Masami Shinohara, Taku Masuyama, and Akihiro Kakehashi

Cohen diabetic rat / Sarah Weksler-Zangen, Esther Orlanski, David H. Zangen

KK and KKAy mice: models of type 2 diabetes with obesity / Shigehisa Taketomi

Animal models to study obesity and type 2 diabetes induced by diet / Tamer Coskun ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

0849395348

9780849395345

OCLC:

74459757

Online:

Publisher description