Stress and addiction : biological and psychological mechanisms / edited by Mustafa al'Absi.

Format:

Book

Contributor:

Absi, Mustafa al.

Language:

English

Subjects (All):

Drug abuse--Physiological aspects.

Stress (Psychology)--Physiological aspects.

Drug abuse--Psychological aspects.

Stress (Psychology).

Stress--complications.

Substance-Related Disorders--etiology.

Stress, Psychological--complications.

Drug abuse.

Medical Subjects:

Stress--complications.

Substance-Related Disorders--etiology.

Stress, Psychological--complications.

Physical Description:

xvi, 431 pages : illustrations ; 27 cm

Place of Publication:

Amsterdam ; Boston : Elsevier Academic Press, [2007]

Summary:

Stress is one of the most commonly reported precipitants of drug use and is considered the number one cause of relapse to drug abuse. For the past several decades, there have been a number of significant advances in research focusing on the neurobiological and psychosocial aspects of stress and addiction. Along with this growth came the recognition of the importance of understanding the interaction of biological and psychosocial factors that influence risk for initiation and maintenance of addictive behaviors. Recent research has started to specifically focus on understanding the mechanisms of stress and how it contributes to addictive tendencies. This growing interest has influenced the way we think about addiction and its etiological factors and has produced exciting possibilities for developing effective intervention strategies.

Stress and Addiction: Biological and Psychological Mechanisms is a highly focused work that integrates and consolidates available knowledge to provide a resource for researchers, practitioners, and trainees across multiple disciplines such as neuroscience, social science, and psychology. This volume not only addresses the role of stress in addictive behaviors, but will also serve as a key reference for those conducting research in this field.

From the Foreword by George F. Koob, Scripps Research Institute: "The present treatise provides a broad and in depth perspective of the many domains by which stress and addiction may intersect. Compiled by leaders of the field and representing a translational approach, the book provides a much needed resource for research already completed and a resource that will stimulate new research in the field. Given the burgeoning interest in novel treatments for drug addiction, the information in the present work also provides new conceptualizations and novel frameworks for the aspects of the addiction process clearly driven by a dysregulated stress system."

Contents:

Section I Neurobiology of Stress and Addiction

1 Biological Bases of the Stress Response / Brigitte M. Kudielka, Clemens Kirschbaum 3

II Physiological Stress Research 4

III Major Components of the Biological Stress Response System 7

IV Other Stress-Responsive Hormone Axes 10

V Other Stress-Responsive Systems 12

2 The Hypothalamic-Pituitary-Adrenal Axis and Addiction / Nicholas E. Goeders 21

II Stress and the HPA Axis 22

III Stress, the HPA Axis, and the Acquisition of Drug Taking 23

IV Stress and Vulnerability to Addiction in Humans 25

V The HPA Axis and the Maintenance of Drug Taking 26

VI Relapse to Addiction 28

VII Inconsistencies 30

VIII Conclusions and Implications for the Treatment of Addiction 33

3 Dopaminergic Reward Pathways and Effects of Stress / Michela Marinelli 41

I Defining Stress 41

II The Mesencephalic Dopamine System 42

III Dopamine and Addiction 48

IV Dopamine and Stress 52

4 Endogenous Opiates, Addiction, and the Stress Response / Rachel Y. Chong, Magdalena Uhart, Gary S. Wand 85

II The Endogenous Opioid System 86

III The Endogenous Opioid System and Reward and Reinforcement 86

IV Effect of Alcohol on Endogenous Opioid Activity 87

V Effect of Alcohol on Endogenous Opioid Receptors 88

VI Endogenous Opioid Activity and Receptors and Alcohol Preference 88

VII Opioid Antagonists in the Treatment of Alcohol Addiction 90

VIII Endogenous Opioid Activity and Receptors and Cocaine Preference 91

IX Opioid Antagonists in the Treatment of Cocaine Addiction 91

X Opioids and Risk for Alcoholism 92

XI The [Mu]-Opioid Receptor Gene 95

5 Early Life Stress and Vulnerability to Addiction / Therese A. Kosten, Priscilla Kehoe 105

II Neurohormonal Mechanisms of Stress Relevant to Cocaine Addiction 106

III Animal Models 108

IV Neurohormonal Effects of Neonatal Isolation 110

V Behavioral Effects of Neonatal Isolation 112

VI Sex Differences and Estrous Stage Effects of Neonatal Isolation 118

VII Maternal Care Hypothesis 118

VIII Conclusions and Translation for Clinical Relevance 119

6 Genetics, Stress, and the Risk for Addiction / Mary-Anne Enoch 127

II The Extent of the Problem: Prevalence of Addiction 128

III Heritability of Addiction 128

IV HPA Axis 130

V The "Reward" Pathway of Addiction: Interaction with Stress 132

VI Reward Pathway and Stress Response: Key Neurotransporter Systems 133

VII Limbic Regulation of Response to Stress 137

VIII The Locus Coeruleus (LC)-Norepinephrine (NE) System 138

7 Neurobiology of Stress and Risk for Relapse / Suzanne Erb 147

II Animal Models for Studying the Effects of Stress on Relapse to Drug Seeking: The Reinstatement Procedure 148

III The Neurobiology of Stress-Induced Reinstatement of Drug Seeking 152

IV Long-Lasting Changes in the Responsivity of the Central Nervous System to CRF: Behavioral and Neuroanatomical Studies with Potential Implications for Reinstatement 158

Section II Psychosocial Processes Related to Stress and Addiction

8 Negative Affect and Addiction / Jon D. Kassel, Jennifer C. Veilleux, Margaret C. Wardle, Marisa C. Yates, Justin E. Greenstein, Daniel P. Evatt, Linda L. Roesch 171

II Precisely What Is Negative Affect? 174

III Historical Perspectives on the Role of Withdrawal, Negative Affect, and Substance Abuse 176

IV Drug Expectancy Effects and NA 178

V Initiation Stage: Drug Use and NA 179

VI Maintenance Stage: Drug Use and NA 180

VII Relapse Stage: Drug Use and NA 182

VIII Conclusions and Future Directions 182

9 Stress and Impulsive Behaviors / Christopher B. Donahue, Jon E. Grant 191

II Impulse Control and Substance Use Disorders 192

III Reward-Seeking Behavior: Pathological Gambling (PG) 192

IV Habit Behavior: Trichotillomania (TTM) 198

V Lack of Premeditation: Intermittent Explosive Disorder (IED) 201

10 Psychosocial Determinants of the Stress Response / Andrew Steptoe, Mark Hamer 211

II Sociodemographic Factors and Stress Responses 213

III Life Stress Exposure 215

IV Protective Psychosocial Factors 220

11 Individual Differences in Response to Stress and Risk for Addiction / William R. Lavallo 227

II Stress and the Brain's Motivational Systems 228

III Hedonic Homeostasis in Addiction Risk 230

IV Affective Regulation and Vulnerability to Addiction 231

V Addictions and Abnormalities of HPAC Regulation of Cortisol Secretion 232

VI Risk for Addiction, Central Opioid Function, and Regional Brain Function 235

VII The VAL[superscript 158]MET Polymorphism and Opioid Function 238

VIII Addiction, Response to Stress, and Hedonic Dysregulation 241

IX Life Events, Behavioral Dispositions, and Addiction Risk 243

12 Addiction and Stress in Adolescents / Susan R. Tate, Katherine A. Patterson, Bonnie J. Nagel, Kristin G. Anderson, Sandra A. Brown 249

II Adolescent Development 250

III Life Stress in Adolescence 252

IV Adolescent Stress and Addictive Behaviors 254

V Implications for Adolescent Addiction Interventions 257

Section III Clinical Implications: Assessment and Intervention

13 Assessment of Stress in Research and Clinical Settings / Gary L. Davis, Mustafa al'Absi, Jane Hovland 265

II The Assessment of Stressful Life Events 266

III The Assessment of Self-Reported Stress 269

IV Biological and Physiological Assessment 273

V Hypothalamic-Pituitary-Adrenocortical (HPA) Measures 273

VI The Sympatho-Adreno-Medullary (SAM) System 275

VII The Immune Response 277

14 Assessment of Addictions in Clinical and Research Settings / Michael Ellery, Sherry H. Stewart 285

II Addiction Screens 287

III Diagnostic Measures 290

IV Symptom Severity Measures 291

V Behavioral Measures 292

VI Treatment Planning 293

15 Stress, Anxiety, and Addiction: Intervention Strategies / Christopher B. Donahue, Matt G. Kushner 301

II Stress-Related Substance Use Disorders (SUDs) 303

III Anxiety Disorders and Substance Use Disorders (SUDs) 304

IV Moderators of the Anxiety and SUD Association 304

V Treatment of Comorbid Disorders 305

VI Anxiety and SUD Treatment Program Concepts 306

VII Anxiety and SUD Treatment Outcomes 307

VIII Treatment Studies Reviewed 307

16 Post-traumatic Stress Disorder and Substance Use Disorders / Miguel E. Roberts, Scott D. Moore, Jean C. Beckham 315

I Epidemiology and Course 315

II Genetics of PTSD and Addiction 319

III Neurobiology of Stress and Substance Abuse Disorders 321

IV Treatment Implications 322

V Summary and Future Directions 326

17 Novel Pharmacologic Treatment of Stress and Addiction: The Role of CRF and Glucocorticoid Antagonists / Daniel Saal, Charles B. Nemeroff 333

I General Mechanisms of Addiction 333

II Behavioral Paradigms 334

III General Mechanisms of Stress Response 336

IV Corticotropin-Releasing Factor 336

V Glucocorticoids 337

VI CRF Receptors 337

VII CRF Pharmacology 337

VIII CRF in Addiction and Stress 338

IX Corticosteroids and Addiction 341

X Stress and Addiction: Mechanistic Overview 341

XI Clinical Trials with CRF Compounds 342

Disclosure 343

18 Current and Future Directions of Research on Stress and Addictive Behaviors / Mustafa al'Absi 349

II Working Model 350

III Stress and Vulnerability to Addiction 351

IV Stress and Ongoing Addiction and Relapse 354

V Factors Affecting Stress and Addiction Interactions 357

VI Stress, Poor Behavioral Regulation, and Addiction 360

VII Coping Resources 361

VIII Discussions and Future Directions 361.

Notes:

Includes bibliographical references and indexes.

ISBN:

0123706327

9780123706324

OCLC:

70775781

Online:

Publisher description