Actin-monomer-binding proteins / [edited by] Pekka Lappalainen.

Format:

Book

Contributor:

Lappalainen, Pekka, Ph. D.

Series:

Molecular biology intelligence unit (Unnumbered)

Molecular biology intelligence unit

Language:

English

Subjects (All):

Actin.

Carrier proteins.

Actin Depolymerizing Factors.

Actins.

Profilins.

Medical Subjects:

Actin Depolymerizing Factors.

Actins.

Profilins.

Physical Description:

118 pages : illustrations (some color) ; 24 cm.

Place of Publication:

Austin, Tex. : Landes Bioscience/Eurekah.com ; New York, N.Y. : Springer Science + Business Media, [2007]

Contents:

1 How Actin Assembly Is Modulated at Filament Barbed Ends in Motile Processes / Marie-France Carlier, Dominique Pantaloni, Stephane Romero, Christophe Le Clainche 1

Proteins That Control Barbed End Assembly by Interacting Specifically with Actin Filament Barbed Ends 2

Proteins That Control Barbed End Assembly by Acting on Pointed End Disassembly: ADF/Cofilin 6

Proteins That Control Filament Assembly by Interacting with G-Actin 7

2 Proteins of the Actin Depolymerizing Factor/Cofilin Family / Janel D. Funk, James R. Bamburg 11

Overview of the ADF/Cofilin Family 11

Structure and Function of ADF/Cofilin 15

Regulation of ADF/Cofilin Activity 17

Role of ADF/Cofilin Proteins in Cell Biology and Development 21

3 Profilin, an Essential Control Element for Actin Polymerization / Roger Karlsson, Uno Lindberg 29

Profilin and Profilin: Actin 29

Isoform Diversity 30

The Profilin Structure 30

Poly-(L-Proline) and Profilin 31

Structure of Profilin: Actin and Its Role in Filament Formation 32

Polyphosphoinositides and Profilin 33

Profilin in Cell Motility 34

Profilin in the Nucleus 36

Profilin in the Brain 37

4 Srv2/Cyclase-Associated Protein (CAP): A Multi-Functional Recycling Center for Actin Monomers and Cofilin / Bruce L. Goode 45

CAP Atomic Structure and Assembly into Complexes 46

Biochemical Properties of the CAP-Actin Association 49

CAP Mechanism and Cellular Function 50

In Vivo Regulation of CAP 50

5 Twinfilin Family of Actin Monomer-Binding Proteins / Elisa M. Nevalainen, Ville O. Paavilainen, Pekka Lappalainen 53

Structural Features of Twinfilin 54

Biochemical Properties and Interaction Partners of Twinfilin 55

Phenotypes and Cell Biological Functions 56

Regulation of Twinfilin's Activity 58

The Role of Twinfilin in Actin Dynamics 58

6 Intracellular [Beta]-Thymosins / Ewald Hannappel, Thomas Huff, Daniel Safer 61

Amino Acid Sequences and Phylogenetic Distribution of [Beta]-Thymosins 61

Cell and Tissue Distribution 62

Structure of [Beta]-Thymosins 62

Intracellular Distribution of Thymosin [Beta]4 63

[Beta]-Thymosin/WH2 Domain 63

Sequestering of G-Actin by [Beta]-Thymosins 63

Structure of the G-Actin-Thymosin [Beta]4 Complex 65

Extracellular [Beta]-Thymosins 66

Apoptosis and [Beta]-Thymosins 66

Quantitative Determination and Expression of [Beta]-Thymosins 67

Isolation of [Beta]-Thymosins 68

Outstanding Questions 68

7 Multirepeat [Beta]-Thymosins / Marleen Van Troys, Stien Dhaese, Joel Vandekerckhove, Christophe Ampe 71

The Multirepeat [Beta]-Thymosin Family: Evolutionary Relationships and Structural Characteristics 72

Biochemical Studies Reveal Functional Versatility within the [Beta]-Thymosin Repeats in Affecting Actin Dynamics 76

Multirepeat [Beta]-Thymosins Are Essential in Neuronal Development and Plasticity and/or in Reproduction 78

8 Wasp and Wave Family Proteins / Emanuela Frittoli, Andrea Disanza, Giorgio Scita 83

Promoting Branched Elongation of Actin Filaments through the Arp2/3 Complex 84

Structural Features of Wasp and N-Wasp and Wave Proteins 85

N-Wasp Mediated Actin Polymerization Events 87

Wave-Complexes Acts as Signaling Machineries in Cellular Protrusions 89

9 The Verprolins as Regulators of Actin Dynamics / Pontus Aspenstrom 97

The Verprolins Have Multiple Binding Partners 97

Genetic Links to Actin Regulation 99

The Vertebrate Verprolins as Actin Binding Proteins 101

Verprolin and the Wasp Family of Proteins 102

Verprolin and the Wiskott-Aldrich Syndrome 102

10 A Common Binding Site for Actin-Binding Proteins on the Actin Surface / Roberto Dominguez 107

A Prevalent Target-Binding Cleft in Actin 108

Conformational Plasticity of the Target-Binding Cleft in Actin 111

Crosstalk between the Target-Binding and Nucleotide Clefts 112

Implication for Other Actin-Binding Proteins 112.

Notes:

Includes bibliographical references and index.

ISBN:

0387464050

9780387464053

OCLC:

79447483