Sigma receptors : chemistry, cell biology and clinical implications / edited by Rae R. Matsumoto, Wayne D. Bowen and Tsung-Ping Su.

Format:

Book

Contributor:

Matsumoto, Rae R., 1963-

Bowen, Wayne Darrell, 1952-

Su, Tsung-Ping.

Language:

English

Subjects (All):

Cell receptors.

Receptors, sigma--chemistry.

Receptors, sigma--therapeutic use.

Medical Subjects:

Receptors, sigma--chemistry.

Receptors, sigma--therapeutic use.

Physical Description:

x, 413 pages : illustrations ; 25 cm

Place of Publication:

New York : Springer, [2007]

Summary:

Sigma receptors are promising drug development targets for a host of neurological, psychiatric, oncological, immunological, cardiovascular, ophthalmological, and gastrointestinal disorders. They are structurally unique proteins that are distinct from classical G protein-coupled receptors, ionotropic receptors, or receptor tyrosine kinases. With two subtypes currently known, they modulate cell survival and excitability, and subserve many critical functions in the body. Endogenous ligands for these receptors are unknown, though current clues point to neurosteroids.

This book provides a timely update on the medicinal chemistry, cell biology, and clinical implications of sigma receptors. It puts the information in a historical perspective to help newcomers to the field successfully navigate the confusing early history surrounding these proteins, and provides a launching point for the development of exciting, new research.

Sigma Receptors: Chemistry, Cell Biology and Clinical Implications will be a valuable tool for pharmacologists, medicinal chemists, cell biologists, molecular biologists, clinicians, and others interested in a concise, state-of-the-art overview of the sigma receptor field with a particular view towards novel therapeutic advances.

Contents:

1 [sigma] Receptors: Historical Perspective and Background / Rae R. Matsumoto 1

2 Medicinal Chemistry: New Chemical Classes and Subtype-Selective Ligands / Amy Hauck Newman, Andrew Coop 25

3 Irreversible [sigma] Compounds / Giuseppe Ronsisvalle, Orazio Prezzavento 45

4 Pharmacophore Models for [sigma][subscript 1] Receptor Binding / Seth Y. Ablordeppey, Richard A. Glennon 71

5 Cloning of [sigma][subscript 1] Receptor and Structural Analysis of its Gene and Promoter Region / Vadivel Ganapathy, Malliga E. Ganapathy, Katsuhisa Inoue 99

6 Site-Directed Mutagenesis / Hideko Yamamoto, Toshifumi Yamamoto, Keiko Shinohara Tanaka, Mitsunobu Yoshii, Shigeru Okuyama, Toshihide Nukada 113

7 [sigma] Receptor Modulation of Ion Channels / Chris P. Palmer, Ebru Aydar, Meyer B. Jackson 127

8 Subcellular Localization and Intracellular Dynamics of [sigma][subscript 1] Receptors / Teruo Hayashi, Tsung-Ping Su 151

9 Intracellular Signaling and Synaptic Plasticity / Francois P. Monnet 165

10 Modulation of Classical Neurotransmitter Systems by [sigma] Receptors / Linda L. Werling, Alicia E. Derbez, Samer J. Nuwayhid 195

11 [sigma][subscript 2] Receptors: Regulation of Cell Growth and Implications for Cancer Diagnosis and Therapeutics / Wayne D. Bowen 215

12 Cognitive Effects of [sigma] Receptor Ligands / Tangui Maurice 237

13 [sigma] Receptors and Schizophrenia / Xavier Guitart 273

14 Potential Role of [sigma] Ligands and Neurosteroids in Major Depression / Guy Debonnel, Malika Robichaud, Jordanna Bermack 293

15 [sigma] Receptors and Drug Abuse / Yun Liu, Yongxin Yu, Jamaluddin Shaikh, Buddy Pouw, AnTawan Daniels, Guang-Di Chen, Rae R. Matsumoto 315

16 [sigma][subscript 1] Receptors and the Modulation of Opiate Analgesics / Gavril W. Pasternak 337

17 [sigma] Receptors in the Immune System: Implications for Potential Therapeutic Intervention - an Overview / Sylvaine Galiegue, Hubert Vidal, Pierre Casellas 351

18 [sigma] Receptors and Gastrointestinal Function / Francois J. Roman, Maria Chovet, Lionel Bueno 371.

Notes:

Includes bibliographical references and index.

ISBN:

0387365125

9780387365121

0387365141

9780387365145

OCLC:

77077712