Neurobiology of Alzheimer's disease : molecular and cellular neurobiology / edited by David Dawbarn, Shelley J. Allen.

Format:

Book

Contributor:

Dawbarn, David.

Allen, Shelley J.

Series:

Molecular and cellular neurobiology series

Language:

English

Subjects (All):

Alzheimer's disease--Pathophysiology.

Alzheimer's disease.

Molecular neurobiology.

Alzheimer Disease--physiopathology.

Neurobiology.

Medical Subjects:

Alzheimer Disease--physiopathology.

Neurobiology.

Physical Description:

xviii, 468 pages, 8 unnumbered pages of plates : illustrations (partly color) ; 26 cm.

Edition:

Third edition.

Place of Publication:

Oxford ; New York : Oxford University Press, 2007.

Summary:

Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable account of the disease, from molecular pathology to clinical practice.

The book is intended for readers new to the field, but it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration, or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice, and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations, and known structures.

It will be essential reading for students, researchers, and clinicians interested in neurodegeneration, giving a coherent and cohesive approach to the whole area of research. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Contents:

Alzheimer's disease: a hundred years of investigation / Shelley J. Allen

The neuropathology of Alzheimer's disease / Margaret M. Esiri

Molecular genetics of Alzheimer's disease / John S.K. Kauwe and Alison M. Goate

Biology and molecular neuropathology of β-amyloid protein / Edward B. Lee and Virginia M.-Y. Lee

Molecular basis of tau protein pathology: role of abnormal hyperphosphorylation / Khalid Iqbal ... [et al.]

Protein misfolding, aggregation, and fibril formation: common features of cerebral and non-cerebral amyloidosis / Agueda Rostagno, Ratnesh Lal, and Jorge Ghiso

Apolipoprotein E, amyloid β peptide, and Alzheimer's disease / Suzanne E. Wahrle and David M. Holtzman

Presenilins / Kulandaivelu S. Vetrivel and Gopal Thinakaran

Multiple transgenic mouse models for Alzheimer's disease / Dick Terwel ... [et al.]

Inflammation and Alzheimer's disease / Mark P. Mattson

Cellular targets of amyloid β peptide: potential roles in neuronal cell stress and toxicity / Xi Chen, David Stern, and Shi Du Yan

Alzheimer's disease as a neurotransmitter disease / Mitchell K.P. Lai ... [et al.]

NGF family of neurotrophins and their receptors: early involvement in the progression of Alzheimer's disease / Elliott J. Mufson ... [et al.]

Clinical assessment of Alzheimer's disease / Sarmishtha Bhattacharyya, Ross Overshott, and Alistair Burns

Molecular and biological markers for Alzheimer's disease / Henrik Zetterberg and Kaj Blenow

Current pharmacological approaches to treating Alzheimer's disease / Gordon K. Wilcock and David Dawbarn

Amyloid-based therapies / Weiming Xia

Future directions: the Aβ amyloid pathway as the target for diagnosing, preventing, or treating Alzheimer's disease / Colin L. Masters.

Notes:

Includes bibliographical references and index.

ISBN:

0198566611

9780198566618

OCLC:

76820941