Manual of clinical psychopharmacology / Alan F. Schatzberg, Jonathan O. Cole, Charles DeBattista.

Format:

Book

Author/Creator:

Schatzberg, Alan F.

Contributor:

Cole, Jonathan O.

DeBattista, Charles.

Language:

English

Subjects (All):

Psychopharmacology--Handbooks, manuals, etc.

Psychopharmacology.

Psychotropic drugs--Handbooks, manuals, etc.

Psychotropic drugs.

Mental Disorders--drug therapy.

Psychotropic Drugs--pharmacology.

Medical Subjects:

Psychopharmacology.

Mental Disorders--drug therapy.

Psychotropic Drugs--pharmacology.

Genre:

Handbooks and manuals.

Physical Description:

xxv, 697 pages : illustrations ; 21 cm

Edition:

Sixth edition.

Place of Publication:

Washington, DC : American Psychiatric Pub., [2007]

Summary:

This comprehensive clinical guide emphasizes practical advice, i.e., specific recommendations about dosing, titration, and combining medications, and offering general principles of psychopharmacological treatment, as well as advice on legal, ethical, and economic issues. This up-to-date, practical manual will be warmly welcomed not only by practitioners but also nursing and pharmacy students and psychopharmacology residents.

Contents:

1 General Principles of Psychopharmacological Treatment 1

General Advice 3

Practice Guidelines 4

Legal, Ethical, and Economic Issues 4

2 Diagnosis and Classification 15

Mood Disorders 17

Bipolar Disorders 17

Depressive Disorders 19

Schizophrenia and Other Schizophrenia Spectrum Disorders 22

Anxiety Disorders 24

Somatoform Disorders 28

Personality Disorders 28

Psychoactive Substance Use Disorders 29

Child and Adolescent Disorders 30

FDA Approval of Symptom Reduction Strategies 31

DSM-V and Pharmacogenetics 31

3 Antidepressants 35

History 38

General Principles of Antidepressant Use 40

Choosing an Antidepressant 40

Dosage and Administration 44

Duration of Treatment 44

Selective Serotonin Reuptake Inhibitors 46

Pharmacological Effects 46

Indications 51

Side Effects 54

Overdose 61

Drug Interactions 61

Dosage and Administration 53

Discontinuation 67

5-HT[subscript 2] Receptor Antagonists (Trazodone and Nefazodone) 69

Pharmacological Effects 70

Indications 71

Side Effects 72

Overdose 75

Drug Interactions 76

Dosage and Administration 77

Discontinuation 78

Selective Serotonin-Norepinephrine Reuptake Inhibitors (Venlafaxine and Duloxetine) 78

Pharmacological Effects 79

Indications 80

Side Effects 82

Overdose 83

Drug Interactions 83

Dosage and Administration 84

Discontinuation 85

Combined Noradrenergic-Dopaminergic Antidepressant (Bupropion) 85

Pharmacological Effects 86

Indications 87

Side Effects 89

Overdose 89

Drug Interactions 90

Dosage and Administration 90

Mirtazapine 90

Pharmacological Effects 90

Indications 92

Side Effects 93

Overdose 95

Drug Interactions 95

Dosage and Administration 95

Norepinephrine Reuptake Inhibitors: Reboxetine and Atomoxetine 96

Pharmacological Effects 96

Indications 97

Side Effects 98

Overdose 99

Dosage and Administration 99

Drug Interactions 99

Discontinuation 99

Gepirone 100

Tricyclic and Tetracyclic Antidepressants 101

Structures 101

Pharmacological Effects 101

Indications 106

Blood Levels 107

Side Effects 112

Overdose 115

Dosage and Administration 115

Discontinuation 117

Monoamine Oxidase Inhibitors 118

Pharmacological Effects 118

Indications 118

Side Effects 121

Overdose 125

Drug Interactions 125

Dosage and Administration 128

Discontinuation 128

Selective and Reversible Monoamine Oxidase Inhibitors 129

Melatonin Agonist-5-HT[subscript 2C] Antagonist 133

Novel Antidepressants 134

4 Antipsychotic Drugs 159

General Principles of Antipsychotic Use 162

The Drugs 162

Efficacy 168

Acute Antipsychotic Treatment 171

Early Inpatient Treatment 175

Maintenance Drug Therapy 178

Use in Other Psychiatric Disorders 182

Atypical Antipsychotics 189

Clozapine 189

Risperidone 200

Olanzapine 203

Quetiapine 207

Ziprasidone 210

Aripiprazole 212

Standard (Typical) Antipsychotics 214

Side Effects 216

Haloperidol Decanoate 231

Other Options for Treating Negative Symptoms 232

Alternatives to Antipsychotic Therapy 234

Antipsychotic Drugs in Development 236

5 Mood Stabilizers 255

Lithium 257

History and Indications 257

Pharmacological Effects 261

Clinical Indications 262

Side Effects 269

Preparations 276

Dosage and Administration 277

Use in Pregnancy 279

Lithium Information Center 280

Anticonvulsants 280

Valproate 281

Carbamazepine 294

Lamotrigine 301

Other Anticonvulsants 306

Antipsychotics 317

Benzodiazepines 319

Calcium Channel Blockers 320

Omega-3 Fatty Acids 321

6 Antianxiety Agents 337

Benzodiazepines 340

Indications 340

Pharmacological Effects 342

Subclasses 343

Dosage and Administration 348

Withdrawal 352

Side Effects 355

Overdose 355

Antidepressants 356

Agoraphobia and Panic 356

Generalized Anxiety Disorder 357

Social Phobia 358

Body Dysmorphic Disorder 360

Posttraumatic Stress Disorder 360

Obsessive-Compulsive Disorder 364

Anticonvulsants 366

Antipsychotics 368

Noradrenergic Agents 369

Clinical Indications 369

Dosage and Administration 370

Side Effects 371

Antihistamines 372

Buspirone 372

Barbiturates 375

Amobarbital Sodium (Amytal) as a Parenteral Solution 377

Catatonia 382

Meprobamate 384

7 Hypnotics 395

Insomnia 395

Behavioral Approaches 401

Pharmacological Approaches 401

Benzodiazepine Hypnotics 403

Nonbenzodiazepine Hypnotics 409

Melatonin Receptor Agonist: Ramelteon 411

Sedative Antihistamines and Other Nonbenzodiazepine Psychoactive Drugs With Hypnotic Properties 412

Barbiturates 414

Nonbarbiturate Hypnotics 417

Methaqualone 419

Over-the-Counter Sleeping Agents 420

L-Tryptophan 420

Melatonin 421

Valerian Extract 422

8 Stimulants and Other Fast-Acting Drugs 429

Amphetamine Abuse 434

Uses of Stimulants 436

Attention-Deficit/Hyperactivity Disorder 436

Depression 439

Acquired Immunodeficiency Syndrome 443

Other Medical Conditions 444

Drug Combinations 444

Psychosis 445

Stimulant Use Versus Abuse 446

Other Fast-Acting Drugs 447

9 Augmentation Strategies for Treatment-Resistant Disorders 453

Augmentation Strategies for Depression 454

Lithium-Antidepressant Combinations 454

Thyroid Supplement-Antidepressant Combinations 457

Estrogen, DHEA, and Testosterone Combinations With Antidepressants 460

Dopamine Agonist-Antidepressant Combinations 463

Monoamine Precursor-Antidepressant Combinations 464

SSRI Combinations 465

Antipsychotic-Antidepressant Combinations 469

Other TCA Combinations 471

Augmentation Strategies for Bipolar Disorder 473

Combinations of Two or More Mood Stabilizers 473

Mood Stabilizer-Antipsychotic Combinations 475

Mood Stabilizer-Antidepressant Combinations 477

Mood Stabilizers and Omega-3 Fatty Acids 478

Augmentation Strategies for Schizophrenia 479

Combinations of Two Antipsychotics 479

Combinations of Antidepressants and Antipsychotics 480

Combinations of Mood Stabilizers and Antipsychotics 481

Other Augmentation Strategies 483

10 Emergency Room Treatment 499

Agitation and Violence 500

Depression and Suicidality 504

Acute Psychotic Reactions 508

Mixed Psychotic Reactions 508

Schizophrenic, Schizophreniform, and Manic Psychoses 509

Delirium 511

Severe Anxiety 512

Stupor and Catatonia 513

Emergency Room Referrals 514

11 Pharmacotherapy for Substance Use Disorders 519

Drug Testing 521

Stimulants 522

Opiates 523

Detoxification 523

Maintenance 526

Sedatives and Hypnotics 530

Detoxification 530

Pentobarbital Tolerance Test 531

Benzodiazepines 532

Alcohol 534

Maintenance Treatment 537

Cannabis 541

Hallucinogens 542

Phencyclidine 542

12 Pharmacotherapy in Special Situations 549

Pregnancy 549

Pediatric Psychopharmacology 556

Stimulants 557

Antipsychotics 561

Antidepressants 565

Mood Stabilizers 568

Antianxiety Drugs 570

Geriatric Psychopharmacology 571

Antidepressants 572

Hypnotics and Anxiolytics 574

Mood Stabilizers 575

Antipsychotics 576

Medications for Dementia 578

Medications for Agitation 582

Mental Retardation 584

Medical Conditions 587

Psychiatric Disorders Resulting From Medical Illness 587

Psychiatric Disorders Associated With Nonpsychiatric Drugs 590

Psychiatric Disorders Complicated by Medical Disorders 591

13 Herbals and Dietary Supplements 619

St.

John's Wort (Hypericum Perforatum) 621

Uses 623

Mechanism of Action 624

Side Effects and Drug Interactions 624

Dosage and Administration 625

Omega-3 Fatty Acids 625

Uses and Mechanism of Action 626

Side Effects and Drug Interactions 626

Dosage and Administration 627

Kava (Piper Methysticum) 627

Uses 627

Mechanism of Action 627

Side Effects and Drug Interactions 628

Dosage and Administration 628

Valerian (Valeriana Officinalis) 629

Uses 629

Mechanism of Action 629

Side Effects and Drug Interactions 629

Dosage and Administration 630

Ginkgo (Ginkgo Biloba) 630

Uses 630

Mechanism of Action 630

Side Effects and Drug Interactions 630

Dosage and Administration 631

Folate and B Vitamins 631

S-Adenosylmethionine (SAMe) 632

Uses 632

Mechanism of Action 633

Side Effects and Drug Interactions 633

Dosage and Administration 633

Inositol 634

Uses 634

Mechanism of Action 634

Side Effects and Drug Interactions 635

Dosage and Administration 635

DHEA (Dehydroepiandrosterone) 635

Uses 635

Mechanism of Action 636

Side Effects and Drug Interactions 636

Dosage and Administration 636

Appendix A Strengths and Costs of Antidepressant and Antipsychotic Drugs 641.

Notes:

Includes bibliographical references (pages 645-646) and index.

ISBN:

1585623172

9781585623174

OCLC:

81944018