Parkinson's disease : genetics and pathogenesis / edited by Ted M. Dawson.

Format:

Book

Contributor:

Dawson, Ted Murray.

Series:

Neurological disease and therapy ; v. 83.

Neurological disease and therapy ; 83

Language:

English

Subjects (All):

Parkinson's disease--Genetic aspects.

Parkinson's disease.

Parkinson's disease--Pathophysiology.

Parkinson Disease--genetics.

Parkinson Disease--physiopathology.

Medical Subjects:

Parkinson Disease--genetics.

Parkinson Disease--physiopathology.

Physical Description:

ix, 386 pages : illustrations ; 24 cm.

Place of Publication:

New York : Informa Healthcare, [2007]

Summary:

An authoritative collection of recent breakthroughs in Parkinson's disease (PD) research, this reference spans key findings on the mechanisms of neurodegeneration and the role of specific genes that may lead to improved therapies for PD. This guide will review the major aspects of the disease including motoric and pathologic features, and autonomic dysfunction, sleep disorders, and neuropsychiatric manifestations, as well as provide an in-depth review of genetic considerations. With contributions by recognized experts on the topic, this source will address the pathogenesis, experimental models, future therapeutic opportunities, and research trends affecting the field. Compiled by a gold-standard editorial team, this source studies the pathogenic hypothesis of PD including alpha-synuclein, parkin, LRRK2, DJ-1, PINK 1, mitochondrial dysfunction, and ubiquitin proteasomal dysfunction...examines various animal models and pinpoints exciting new targets for therapeutics...collects new research on the mechanisms of neuronal cell death and the elucidation of the molecular mechanisms of neurodegeneration...and analyzes drug trials in animal models of PD.

Contents:

1 Neuropathology and Staging of Parkinson's Disease / Dennis W. Dickson 1

2 Genetics of Parkinson's Disease / Andrew B. Singleton, Jordi Clarimon 19

3 Epidemiology of Parkinson's Disease / Anabel Chade, Meike Kasten, Caroline M. Tanner 35

4 Treatment of Parkinson's Disease / Stanley Fahn 53

Section II Genetics

5 Genetics of [alpha]-Synuclein / Andrew Whittle, Matt Farrer 75

6 Clinical and Genetic Features of PARKIN-Related Parkinson's Disease / Ebba Lohmann, Alexis Brice, Alexandra Durr, Merle Ruberg 83

7 Genetics: DJ-1 in Parkinson's Disease / Peter Heutink 99

8 PINK1 Parkinsonism / Patrick M. Abou-Sleiman, Miratul M. K. Muqit, Nicholas W. Wood 115

9 LRRK2: Genetics and the Pathogenic Mechanisms of Parkinsonism / Mark R. Cookson 127

10 Genetics of Tau in Parkinsonism / Rosa Rademakers, Marc Cruts, Christine van Broeckhoven 135

11 Genetic Risk Factors for Parkinson's Disease / Sofia A. Oliveira, Jeffery M. Vance 153

Section III Pathogenesis

12 [alpha]-Synuclein and Parkinson's Disease / James H. Soper, John Q. Trojanowski, Virginia M.-Y. Lee 167

13 Tau in Parkinsonian Diseases / Daniel M. Skovronsky, Virginia M.-Y. Lee, John Q. Trojanowski 187

14 The Role of PARKIN in Parkinson's Disease / Andrew B. West, Valina L. Dawson, Ted M. Dawson 199

15 Mitochondrial Complex I Deficiency in Parkinson's Disease: A Mechanism for Oxidant-Based Pathogenesis / Tatyana V. Votyakova, Ian J. Reynolds 219

16 The Ubiquitin-Proteasome System in Parkinson's Disease / Leonidas Stefanis 237

Section IV Animal Models

17 Transgenic Models of [alpha]-Synucleinopathy / Michael K. Lee 251

18 Mouse Models of Recessive Parkinsonism / Matthew S. Goldberg, Jie Shen 269

19 Drosophila Models of Parkinson's Disease / Leo J. Pallanck, Alexander J. Whitworth 287

20 Caenorhabditis elegans Models of Parkinson's Disease / Garry Wong 311

21 The MPTP Model of Parkinson's Disease / Serge Przedborski 325

22 Rotenone Model for Parkinson's Disease / Ranjita Betarbet, J. Timothy Greenamyre 351

23 Drug Trials in Animal Models of Parkinson's Disease / Daniel S. Sa, M. Flint Beal 367.

Notes:

Includes bibliographical references and index.

ISBN:

084933697X

9780849336973

OCLC:

85885365

Online:

Publisher description