Brain aging : models, methods, and mechanisms / edited by David R. Riddle.

Format:

Book

Contributor:

Riddle, David R.

Series:

Frontiers in neuroscience (Boca Raton, Fla.)

Frontiers in neuroscience

Language:

English

Subjects (All):

Brain--Aging.

Brain.

Brain--physiopathology.

Aging--physiology.

Cognition--physiology.

Nerve Degeneration.

Medical Subjects:

Brain--physiopathology.

Aging--physiology.

Cognition--physiology.

Nerve Degeneration.

Physical Description:

xix, 384 pages, 8 unnumbered pages of plates : illustrations (partly color) ; 25 cm.

Place of Publication:

Boca Raton : CRC Press, [2007]

Summary:

Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur, new possibilities emerge for limiting the effects of aging on neural function. Outlining the newest methods and techniques, Brain Aging: Models, Methods, and Mechanisms provides scientists, researchers, and clinicians with a broad understanding of the important progress and implications for the future of this important field.

Features: Emphasizes fundamental age-related change in the brain, rather than pathological neurodegenerative disease, Provides a comprehensive picture of the mechanism of aging by integrating insights furnished by high resolution functional brain imaging in humans as well as the experimental study of animal models (including rodents and primates), Looks at unbiased methods for quantifying changes in the brain, stereological methods for clarifying the extent and nature of anatomical changes, and methodological challenges inherent in studies of the aging nervous system, Discusses structural and functional changes at the molecular, systems, and cognitive levels.

Contents:

Changes in cognitive function in human aging / Elizabeth L. Glisky

Successful vs. unsuccessful aging in the Rhesus monkey / Mark B. Moss ... [et al.]

Neuropsychology of cognitive aging in rodents / Joshua S. Rodefer and Mark G. Baxter

Design-based stereology in brain aging research / Cristoph Schmitz and Patrick R. Hof

The effects of normal aging on nerve fibers and neuroglia in the central nervous system / Alan Peters

Neurogenesis in the adult and aging brain / David R. Riddle and Robin J. Lichtenwalner

Expression profile analysis of brain aging / Stephen D. Ginsberg

Subtle alterations in glutamatergic synapses underlie the aging-related decline in hippocampal function / Lei Shi, Michelle Adams, and Judy K. Brunso-Bechtold

Assessment of second messenger function in the hippocampus of aged rats with cognitive impairment / Michelle M. Nicolle, Hai-Yan Zhang, and Jennifer L. Bizon

Neurophysiology of old neurons and synapses / Ashok Kumar and Thomas C. Foster

Imaging cognition in the aging human brain / Trey Hedden

Regulation of cerebrovascular aging / William E. Sonntag ... [et al.]

Stress and glucocorticoid contributions to normal and pathological aging / Ki A. Goosens and Robert M. Sapolsky

Altered calcium homeostasis in old neurons / Emil C. Toescu

Oxidative stress and the aging brain: from theory to prevention / Carmelina Gemma ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

0849338182

9780849338182

OCLC:

74987991