Apoptosis, cell signaling, and human diseases : molecular mechanisms / edited by Rakesh Srivastava.

Format:

Book

Contributor:

Srivastava, Rakesh, 1956-

Language:

English

Subjects (All):

Apoptosis.

Pathology, Molecular.

Cellular signal transduction.

Apoptosis--physiology.

Cell Transformation, Neoplastic--genetics.

Genetic Therapy.

Signal Transduction.

Medical Subjects:

Apoptosis--physiology.

Cell Transformation, Neoplastic--genetics.

Genetic Therapy.

Signal Transduction.

Physical Description:

2 volumes : illustrations ; 26 cm

Place of Publication:

Totowa, N.J. : Humana Press, [2007]

Summary:

Apoptosis, Cell Signaling, and Human Diseases: Molecular Mechanisms, Volumes 1 & 2, present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.

Volume 1 is divided into two sections: "Malignant Transformation and Metastasis" and "Molecular Basis of Disease Therapy." Volume 2 follows a similar structure and is divided into sections entitled "Kinases and Phosphatases" and "Molecular Basis of Cell Death." All of the contributors are at the forefront of scientific discovery, and the reviews they present systematically examine the most exciting and innovative aspects of their particular areas of expertise. Researchers will find these volumes of major benefit as they search for novel and more effective treatments for human diseases.

Features: Examines the balance between apoptosis and survival pathways in carcinogenesis, Identifies control nodes linking the regulatory networks of the cell cycle and apoptosis, Presents molecular mechanisms of cell death and drug resistance, Explores current and innovative targeted therapies for human disease.

Contents:

Contents of Volume 1 xv

Part I Kinases and Phosphatases

1 Significance of Protein Kinase A in Cancer / Maria V. Nesterova, Yoon S. Cho-Chung 3

2 Protein Kinase C and Apoptosis / Mary E. Reyland 31

3 The Role of Phosphoinositide 3-Kinase-Akt Signaling in Virus Infection / Samantha Cooray 57

4 Cyclin-Dependent Kinase 5: A Target for Neuroprotection? / Frank Gillardon 81

5 Critical Roles of the Raf/MEK/ERK Pathway in Apoptosis and Drug Resistance / James A. McCubrey, Fred E. Bertrand, Linda S. Steelman, Fumin Chang, David M. Terrian, Richard A. Franklin 101

6 MAPK Signaling in Human Diseases / Philippe P. Roux, John Blenis 135

7 Serine/Threonine Protein Phosphatases in Apoptosis / Gro Gausdal, Camilla Krakstad, Lars Herfindal, Stein Ove Doskeland 151

8 Urokinase/Urokinase Receptor-Mediated Signaling in Cancer / Sreerama Shetty, Steven Idell 167

Part II Molecular Basis of Cell Death

9 Signaling Pathways That Protect the Heart Against Apoptosis Induced by Ischemia and Reperfusion / Zheqing Cai, Gregg L. Semenza 181

10 Cyclooxygenase-2 Gene Expression: Transcriptional and Posttransciptional Conrols in Intestinal Tumorigenesis / Shrikant Anant, Sripathi M. Sureban 197

11 Death Receptors: Mechanisms, Biology, and Therapeutic Potential / Sharmila Shankar, Rakesh Srivastava 219

12 DNA Damage-Dependent Apoptosis / Tomasz Skorski 263

13 The Role of Proteasome in Apoptosis / Peter Low 273

14 Apoptosis Induction in T Lymphocytes by HIV / Maria Saveria Gilardini Montani 295

15 Inhibitors of Apoptosis Proteins and Caspases / Jai Y. Yu, John Silke, Paul G. Ekert 313

16 Intracellular Pathways Involved in DNA Damage and Repair to Neuronal Apoptosis / Maurizio Memo 335

17 The Biology of Caspases / Tasman James Daish, Sharad Kumar 347

18 Apoptosis and Human Diseases: Molecular Mechanisms: Oxidative Stress in the Pathogenesis of Diabetic Neuropathy / Mahdieh Sadidi, Ann Marie Sastry, Christian M. Lastoskie, Andrea A. Vincent, Kelli A. Sullivan, Eva L. Feldman 365.

Notes:

Includes bibliographical references and index.

ISBN:

1588296776

9781588296771

1588298825

9781588298829

OCLC:

71427070