Decoding the genomic control of immune reactions.

Format:

Book

Contributor:

Novartis Foundation.

Series:

Novartis Foundation symposium ; 281.

Novartis Foundation symposium ; 281

Language:

English

Subjects (All):

Immunogenetics--Congresses.

Immunogenetics.

Medical Subjects:

Immunogenetics.

Genre:

Conference papers and proceedings.

Physical Description:

ix, 218 pages : illustrations ; 24 cm.

Place of Publication:

Chichester : Wiley, 2007.

Summary:

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the Identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend.

Specific problems addressed include the following: What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance? Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues? Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses? Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

Contents:

David A. Hume, Christine A. Wells, Timothy Ravasi Transcriptional regulatory networks in macrophages 2

/ Christian Schonbach The RIKEN mouse transcriptome: lessons learned and implications for the regulation of immune reactions 25

/ Steven A. Stacker, Rae H. Farnsworth, Tara Karnezis, Ramin Shayan, Darrin P. Smith, Karri Paavonen, Natalia Davydova, Carol Caesar, Rachael Inder, Megan E. Baldwin, Bradley K. McColl, Sally Roufail, Richard A. Williams, Richard A. Hughes, Kari Alitalo, Marc G. Achen Molecular pathways for lymphangiogenesis and their role in human disease 38

/ Jason G. Cyster Specifying the patterns of immune cell migration 54

/ Capucine Picard, Laurent Abel, Jean-Laurent Casanova Human monogenic disorders that center predisposition to specific infections 65

/ W. J. Britton, S. L. Fernando, B. M. Saunders, R. Sluyter, J. S. Wiley The generic control of susceptibility to Mycobacterium tuberculosis 79

/ Bernard Malissen, Ying Wang, Michael Mingueneau, Marie Malissen Th2 lymphoproliferative disorders resulting from defective LAT signalosomes 93

/ Carola G. Vinuesa, Matthew C. Cook Genetic analysis of systematic autoimmunity 103

/ Gunasegaran Karupiah, Vijay Panchanathan, Isaac G. Sakala, Geeta Chaudhri Genetic resistance to smallpox: lessons from mousepox 129

/ Anny Fortin, Eduardo Diez, Janet E. Henderson, Jeffrey S. Mogil, Philippe Gros, Emil Skamene The AcB/BcA recombinant congenic strains of mice: strategies for phenotype dissection, mapping and cloning of quantitative trait genes 141

/ Gundula Min-Oo, Mary M. Stevenson, Anny Fortin, Philippe Gros Genetic control of host-pathogen interactions in mice 156

/ Douglas Young, Anne O'Garra Mycobacterium tuberculosis and its ability to resist immunity 169

/ Grant Morahan, Robert W. Williams Systems genetics: the next generation in generics research? 181

/ Rick Maizels Regulation of the immune system in metazoan parasite infections 192.

Notes:

Includes bibliographical references and index.

ISBN:

9780470027554

047002755X

OCLC:

75713387