Alzheimer's disease : cellular and molecular aspects of amyloid [beta] / edited by J. Robin Harris and Falk Fahrenholz.

Format:

Book

Contributor:

Harris, J. Robin (James Robin)

Fahrenholz, F. (Falk)

Series:

Sub-cellular biochemistry ; v.38.

Sub-cellular biochemistry

Language:

English

Subjects (All):

Alzheimer's disease.

Amyloid beta-protein.

Alzheimer Disease.

Amyloid beta-Peptides.

Medical Subjects:

Alzheimer Disease.

Amyloid beta-Peptides.

Physical Description:

xv, 409 pages : illustrations ; 24 cm.

Place of Publication:

New York : Springer, [2005]

Summary:

This volume contains a survey of present-day research into the biomedical fundamentals of Alzheimer's disease (AD). It contains 20 chapters dealing with widely ranging topics, all of which have a bearing upon the understanding and treatment of AD. Starting with a broad survey of the contribution that the various microscopical techniques (light microscopy, electron microscopy, atomic force microscopy) have made since the seminal light microscopical studies of Alois Alzheimer, the book presents chapters on specialist topics: transgenic mouse models of AD; the enzymology of amyloid-[beta] production and degradation; oxidant stress and antioxidant protection; the involvement of metal ions and the influence of chelators; the importance of amyloid-[beta] oligomers and fibrils, the role of cholesterol in the formation and characteristic binding of the dye Congo red; of the many AD plaque-associated proteins, ApoE4, clusterin and acetylcholinesterase receive individual attention; the effect of amyloid-[beta] on neuronal membrane calcium channels and membrane fluidity are covered, as are drug interactions, the [beta]-sheet breaking peptides and the statins that may prevent oligomer/fibril formation in AD; the possible significance of amyloid-[beta] phosphorylation receives detailed attention.

Overall, the volume contains a broad range of current information on cellular, biochemical, and structural aspects of amyloid-[beta], of direct relevance to Alzheimer's disease.

Contents:

1 The Contribution of Microscopy to the Study of Amyloid Plaques and to Amyloid-[beta] Fibrillogenesis / J. Robin Harris 1

2 Transgenic Mouse Models for APP Processing and Alzheimer's Disease: Early and Late Defects / Tom Van Dooren, Ilse Dewachter, Peter Borghgraef, Fred van Leuven 45

3 Oxidative stress in Alzheimer's Disease: Implications for Prevention and Therapy / Christian Behl 65

4 [beta]-Secretase, APP and A[beta] in Alzheimer's Disease / Robert Vassar 79

5 The Non-Amyloidogenic Pathway: Structure and Function of [alpha]-Secretases / Elzbieta Kojro, Falk Fahrenholz 105

6 Amyloid [beta] Degradation: A Challenging Task for Brain Peptidases / Laura Morelli, Ayelen Bulloj, Maria Celeste Leal, Eduardo M. Castano 129

7 The Protective Role of Vitamin E in Vascular Amyloid [beta]-Mediated Damage / Francisco Jose Munoz, Montserrat Sole, Mireia Coma 147

8 Amyloid Accumulation and Pathogensis of Alzheimer's Disease: Significance of Monomeric, Oligomeric and Fibrillar A[beta] / Charles C. Glabe 167

9 Cholesterol and Amyloid [beta] Fibrillogenesis / Katsuhiko Yanagisawa 179

10 Alzheimer's [beta]-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding / Hideyo Inouye, Daniel A. Kirschner 203

11 The Aluminium-Amyloid Cascade Hypothesis and Alzheimer's Disease / Christopher Exley 225

12 Amyloid-[beta] Metal Interaction and Metal Chelation / Math P. Cuajungco, Christopher J. Frederickson, Ashley I. Bush 235

13 The Interaction of Amyloid-[beta] with ApoE / Donald B. Carter 255

14 Clusterin and Alzheimer's Disease / Miguel Calero, Agueda Rostango, Blas Frangione, Jorge Ghiso 273

15 Acetylcholinesterase Interaction with Alzheimer Amyloid [beta] / Nibaldo C. Inestrosa, Juan Paulo Sagal, Marcela Colombres 299

16 Membrane Disordering Effects of [beta]-Amyloid Peptides / Gunter P. Eckert, W.G. Wood, Werner E. Muller 319

17 The Role of Alzheimer A[beta] Peptides in Ion Transport Across Cell Membranes / Vernon M. Ingram 339

18 Amyloid Inhibitors and [beta]-Sheet Breakers / Claudio Soto, Lisbell Estrada 351

19 Cholesterol and Alzheimer's Disease: Statins, Cholesterol Depletion in APP Processing and A[beta] Generation / Tobias Hartmann 365

20 Phosphorylated Amyloid-[beta]: The Toxic Intermediate in Alzheimer's Disease Neurodegeneration / Nathaniel G. N. Milton 381.

Notes:

Includes bibliographical references and index.

ISBN:

0387232257

OCLC:

57451595

Publisher Number:

0387232265 (e-book)

Online:

Publisher description