Investigative electrocardiography in epidemiological studies and clinical trials / Pentii Rautaharju and Farida Rautaharju.

Format:

Book

Author/Creator:

Rautaharju, P. (Pentti)

Contributor:

Rautaharju, Farida.

Language:

English

Subjects (All):

Electrocardiography.

Heart--Diseases--Epidemiology.

Heart.

Clinical trials.

Heart Diseases--epidemiology.

Clinical Trials as Topic.

Medical Subjects:

Electrocardiography.

Heart Diseases--epidemiology.

Clinical Trials as Topic.

Physical Description:

x, 289 pages : illustrations (partly color) ; 26 cm

Place of Publication:

London : Springer, [2007]

Summary:

Electrocardiology is a relatively new modality in clinical trials, but electrocardiograms (ECGs) have already become established as a valuable research tool for investigation of morbidity and mortality risk associated with various clinical and subclinical conditions. ECGs have also become a crucial tool when investigating adverse cardiac events associated with administration of new drugs.

Investigative Electrocardiography in Epidemiological Studies and Clinical Trials reviews the prevalence and incidence and emphasizes the prognostic implications of common ECG abnormalities in contrasting populations. It provides a comprehensive, penetrating, and critical analysis of topics such as QT prolongation in clinical drug trials, left ventricular hypertrophy, myocardial ischemia/infarction, and epidemiological consideration of relative risks associated with ECG abnormalities. As such, it is an essential tool in epidemiological or clinical research using ECGs and in investigations of possible adverse responses of new pharmacological agents.

With emphasis on providing international coverage of the topic, the well-respected authors present key information on ECG procedures, epidemiology, problem areas, mortality, and morbidity risk. These topics are of particular interest to electrocardiologists, investigators in active ECG research in medical clinics participating in clinical trials, epidemiologists, cardiologists, pharmaceutical companies, and regulatory bodies.

Contents:

Part 1 Investigative Electrocardiography in Epidemiological Studies and Clinical Trials

Chapter 1 Cardiac Excitation and Repolarization 3

Chapter 2 Electrocardiographic Lead Systems 18

Chapter 3 Normal and Arrhythmogenic Ionic Channel Mechanism 29

Chapter 4A Heart Rate and Heart Rate Variability 45

Chapter 4B Methodological Considerations in Heart Rate Variability Analysis 68

Chapter 5 Supraventricular Dysrhythmias 74

Chapter 6A Ectopic Ventricular Activity 100

Chapter 6B Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs 113

Chapter 7A Left Ventricular Hypertrophy 116

Chapter 7B Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage 150

Chapter 8 Prolonged Ventricular Excitation 154

Chapter 9A Old Myocardial Infarction 166

Chapter 9B Attributable Risk 179

Chapter 10A Primary Repolarization Abnormalities 183

Chapter 10B Procedures for Determination of the Spatial QRS/T Angle from Conventional ECG 201

Chapter 11 QT Prolongation and QT Dispersion - a Critical Evaluation 202

Part 2 Normal ECG Standards for Adults by Gender, Age, and Ethnicity

Section A ECG Intervals: Tables 231

Section B ECG Wave Amplitudes: Tables 236

Section C ECG Vector Components and Spatial Magnitudes at Normalized Time Scale: Tables 257

Section D ECG Amplitudes at 10 ms Intervals: Tables 265

Section E Repolarization Waveform Vectors: Tables 272.

Notes:

Includes bibliographical references and index.

ISBN:

1846284656

9781846284656

OCLC:

70264579

Publisher Number:

9781846284656