Misbehaving proteins : protein (mis)folding, aggregation, and stability / edited by Regina M. Murphy, Amos M. Tsai.

Format:

Book

Contributor:

Murphy, Regina M.

Tsai, Amos M.

Language:

English

Subjects (All):

Protein folding.

Cell aggregation.

Protein Folding.

Cell Aggregation.

Medical Subjects:

Protein Folding.

Cell Aggregation.

Physical Description:

viii, 353 pages, 6 unnumbered pages of plates : illustrations (partly color) ; 24 cm

Place of Publication:

New York : Springer, [2006]

Contents:

Protein Folding, Misfolding, Stability, and Aggregation: An Overview / Regina M. Murphy, Amos M. Tsai 3

Part II Mathematical Models and Computational Methods

Nonnative Protein Aggregation: Pathways, Kinetics, and Stability Prediction / Christopher J. Roberts 17

Simulations of Protein Aggregation: A Review / Carol K. Hall, Hung D. Nguyen, Alexander J. Marchut, Victoria Wagoner 47

Part III Experimental Methods

Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry / Erik J. Fernandez, Scott A. Tobler 81

Application of Spectroscopic and Calorimetric Techniques in Protein Formulation Development / Angela Wilcox, Rajesh Krishnamurthy 99

Small-Angle Neutron Scattering as a Probe for Protein Aggregation at Many Length Scales / Susan Krueger, Derek Ho, Amos Tsai 125

Laser Light Scattering as an Indispensable Tool for Probing Protein Aggregation / Regina M. Murphy, Christine C. Lee 147

X-Ray Diffraction for Characterizing Structure in Protein Aggregates / Hideyo Inouye, Deepak Sharma, Daniel A. Kirschner 167

Glass Dynamics and the Preservation of Proteins / Christopher L. Soles, Amos M. Tsai, Marcus T. Cicerone 193

Part IV Fundamental Studies in Model Systems

Folding and Misfolding as a Function of Polypeptide Chain Elongation: Conformational Trends and Implications for Intracellular Events / Silvia Cavagnero, Nese Kurt 217

Determinants of Protein Folding and Aggregation in P22 Tailspike Protein / Matthew J. Gage, Brian G. Lefebvre, Anne S. Robinson 247

Factors Affecting the Fibrillation of [alpha]-Synuclein, a Natively Unfolded Protein / Anthony L. Fink 265

Molten Globule-Lipid Bilayer Interactions and Their Implications for Protein Transport and Aggregation / Lisa A. Kueltzo, C. Russell Middaugh 287

Part V Protein Product Development

Self-Association of Therapeutic Proteins: Implications for Product Development / Mary E. M. Cromwell, Chantel Felten, Heather Flores, Jun Liu, Steven J. Shire 313

Mutational Approach to Improve Physical Stability of Protein Therapeutics Susceptible to Aggregation: Role of Altered Conformation in Irreversible Precipitation / Margaret Speed Ricci, Monica M. Pallitto, Linda Owens Narhi, Thomas Boone, David N. Brems 331.

Notes:

Includes bibliographical references and index.

ISBN:

0387305084

9780387305080

OCLC:

70249224

Online:

Publisher description