The dementias : early diagnosis and evaluation / edited by Karl Herholz, Daniela Perani, Chris Morris.

Format:

Book

Contributor:

Herholz, K. (Karl)

Perani, Daniela.

Morris, Chris, 1965-

Language:

English

Subjects (All):

Dementia--Diagnosis.

Dementia.

Neuropsychological tests.

Biochemical markers.

Diagnostic imaging.

Dementia--diagnosis.

Dementia--etiology.

Biomarkers.

Diagnostic Imaging--methods.

Early Diagnosis.

Neuropsychological Tests.

Medical Subjects:

Dementia--diagnosis.

Dementia--etiology.

Biomarkers.

Diagnostic Imaging--methods.

Early Diagnosis.

Neuropsychological Tests.

Physical Description:

xv, 455 pages, 8 unnumbered pages of plates : illustrations (partly color) ; 24 cm

Place of Publication:

New York : Taylor & Francis, 2006.

Summary:

The only guide to focus primarily on current molecular methods of diagnosis and early stage evaluation, this reference presents the latest techniques and technologies for dementia identification and evaluation, including neuropathological strategies, neuropsychological tests, biomarkers, CT, MRI, functional MRI, PET, and SPECT. Offering practical care and examination guidelines, each chapter provides findings that are particularly relevant for the assessment of disorders such as Alzheimer's disease, dementia with Lewy bodies, vascular dementia, and fronto-temporal dementia.

Boasting an international and expert team of contributors with extensive knowledge of the subject, this source responds to the explosion of advances in the field and discusses the latest methods for the diagnosis and evaluation of dementing disorders...spans molecular and neuropathological methods, advances in neuropsychology, and recent imaging applications...considers the role of genetics in the development of dementia...and analyzes biomarkers in blood and cerebrospinal fluid.

Contents:

1 The Clinical Issues / Norman L. Foster 1

Dementia Evaluation 2

Difficult Diagnostic Crossroads and Decision Points 14

2 Neuropsychological Screening and Advanced Neuropsychological Tests / Daniela Perani 33

Neuropsychological Assessment 34

Assessment of Psychological and Behavioral Disturbances 45

Functional Scales 46

The Role of Neuropsychological Assessment of Dementia 48

Advanced Tests and Future Research Approaches 56

3 Biomarkers in Blood and Cerebrospinal Fluid / Harald Hampel, Katharina Buerger 73

[Beta]-Amyloid Peptide 40 and 42 74

Amyloid Protein Precursor 77

Tau Proteins 78

Apolipoprotein E 82

Isoprostanes 83

[alpha]1-Antichymotrypsin 83

The Soluble Interleukin-6 Receptor Complex 84

C-Reactive Protein 85

C1q 85

Homocysteine 86

Oxysterols and Cholesterol Metabolism 87

3-Nitrotyrosine 88

14-3-3 Protein in Creutzfeldt-Jakob Disease 89

Perspective of Biomarker Research in AD: [Beta]-Amyloid Antibodies 89

4 Genetics: Facts and Perspectives / Sandro Sorbi, Paolo Forleo, Francesca Massaro, Andrea Ginestroni 109

5 Approaches to the Identification of Novel Diagnostic and Therapeutic Targets in Dementia / Kate E. Wilson, Chris Morris 137

Functional Genomics 138

Microarray-Based Gene Expression Profiling 138

Proteomics 142

Fluid Analysis 147

6 Quantitative and Functional Magnetic Resonance Imaging Techniques / Giovanni B. Frisoni, Nicola Filippini 157

Image Acquisition: Technical Features 157

Quantitative Magnetic Resonance Imaging Tools to Rate Regional Atrophy and Cerebrovascular Disease 163

Quantitative Magnetic Resonance Imaging for the Clinical Diagnosis 170

Microstructural Imaging: Diffusion and Magnetization Transfer Imaging 179

Functional Magnetic Resonance Imaging in Dementias and Mild Cognitive Impairment 182

7 Perfusion Imaging with Single Photon Emission Computed Tomography / Nadine J. Dougall, Klaus P. Ebmeier 197

Single Photon Emission Computed Tomography 197

Blood Flow Tracers 198

Alzheimer's Dementia 199

Techniques to Improve Diagnostic Accuracy 202

Cohort Studies 204

Vascular Dementia 204

Frontotemporal Dementia 210

Dementia with Lewy Bodies 215

Mild Cognitive Impairment 215

8 FDG PET: Imaging Cerebral Glucose Metabolism with Positron Emission Tomography / Karl Herholz 229

Positron Emission Tomography 229

Measurement of Local Cerebral Glucose Metabolism 230

Main Findings in Alzheimer's Disease 231

Longitudinal Studies and Trials 235

Early Diagnosis of Alzheimer's Disease 236

Clinical Diagnostic Use of [superscript 18]F-2-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography in Alzheimer's Disease 238

Dementia with Lewy Bodies 238

Frontotemporal Dementia 238

Vascular Dementia 240

Creutzfeldt-Jakob Disease 241

9 Imaging of Neurotransmitter Systems in Dementia / Steen G. Hasselbalch, Gitte M. Knudsen 253

Normal Aging 255

Alzheimer's Disease 257

Lewy Body Dementia 266

Frontotemporal Dementia 268

Cognitive Dysfunction Due to Cerebrovascular Disease 269

10 Development and Application of [Beta]-Amyloid Imaging Agents in Alzheimer's Disease / William E. Klunk, Robert D. Nebes, Nicholas Tsopelas, Brian J. Lopresti, Julie C. Price, Steven T. DeKosky, Chester A. Mathis 279

Development of Amyloid Imaging Technologies 282

Future Applications of Amyloid Imaging 297

11 A View on Early Diagnosis of Dementias from Neuropathology / Kurt A. Jellinger 311

Classification of Dementia Disorders 312

Basic Pathology of Major Dementing Disorders 312

Early Pathology of AD and Clinical Correlates 352

Early Morphological Changes in Dementia Disorders and Relation to Biomarkers 367

Correlation of Clinical and Pathological Criteria 373

Effects of Concurrent Pathologies 373

Neuropathology of AD and Clinical Relevance 374

12 Guideline and Perspective / Karl Herholz, Daniela Perani, Chris Morris 429

Diagnosis of Mild Manifest Dementia 430

Nondemented Subjects with Cognitive Impairment 433

Asymptomatic Subjects 436

Monitoring Treatment 437.

Notes:

Includes bibliographical references and index.

ISBN:

0824728971

9780824728977

OCLC:

65195279

Publisher Number:

9780824728977

Online:

Publisher description