Selenium : its molecular biology and role in human health / edited by Dolph L. Hatfield, Marla J. Berry, and Vadim N. Gladyshev.

Format:

Book

Contributor:

Hatfield, Dolph L.

Berry, Marla J.

Gladyshev, Vadim N.

Language:

English

Subjects (All):

Selenium--Health aspects.

Selenium.

Selenium--Physiological effect.

Selenium in human nutrition.

Selenium--physiology.

Selenium--deficiency.

Selenium--therapeutic use.

Proteins--metabolism.

Antioxidants.

Medical Subjects:

Selenium--physiology.

Selenium--deficiency.

Selenium--therapeutic use.

Proteins--metabolism.

Antioxidants.

Physical Description:

xxii, 419 pages : illustrations (partly color) ; 25 cm

Edition:

Second edition.

Place of Publication:

New York, NY : Springer, [2006]

Summary:

Selenium is an essential trace element in the diet of humans and many other life forms. As discussed in this book, selenium plays an important role in preventing certain forms of cancer, heart disease and other cardiovascular and muscle disorders. Evidence points to numerous other health benefits including an indispensable function in development, male reproduction and the immune system. In addition, selenium serves as an antiviral agent and may delay the onset of AIDS in HIV positive patients and delay the aging process. This element occurs primarily in cellular proteins in the form of a novel amino acid selenocysteine. Selenocysteine is the 21st amino acid in the genetic code and is cotranslationally incorporated into protein in response to the codon, UGA. Selenoproteins control redox homeostasis and are involved in a variety of cellular pathways. The emphasis of this book is on the current status of the molecular biology of selenium. The importance of this element in human health is also highlighted.

Contents:

Chapter 1 Selenium: A historical perspective / James E. Oldfield 1

Part I Biosynthesis of selenocysteine and its incorporation into protein

Chapter 2 Selenium metabolism in prokaryotes / August Bock, Michael Rother, Marc Leibundgut, Nenad Ban 9

Chapter 3 Mammalian and other eukaryotic selenocysteine tRNAs / Bradley A. Carlson, Xue-Ming Xu, Rajeev Shrimali, Aniruddha Sengupta, Min-Hyuk Yoo, Robert Irons, Nianxin Zhong, Dolph L. Hatfield, Byeong Jae Lee, Alexey V. Lobanov, Vadim N. Gladyshev|p29

Chapter 4 Evolution of selenocysteine decoding and the key role of selenophosphate synthetase in the pathway of selenium utilization / Gustavo Salinas, Hector Romero, Xue-Ming Xu, Bradley A. Carlson, Dolph L. Hatfield, Vadim N. Gladyshev 39

Chapter 5 SECIS RNAs and K-turn binding proteins. A survey of evolutionary conserved RNA and protein motifs / Christine Allmang, Alain Krol 51

Chapter 6 SECIS binding proteins and eukaryotic selenoprotein synthesis / Donna M. Driscoll, Paul R. Copeland 63

Chapter 7 The importance of subcellular localization of SBP2 and EFsec for selenoprotein synthesis / Peter R. Hoffmann, Marla J. Berry 73

Chapter 8 Selenocysteine biosynthesis and incorporation may require supramolecular complexes / Andrea L. Small-Howard, Marla J. Berry 83

Part II Selenium-containing proteins

Chapter 9 Selenoproteins and selenoproteomes / Vadim N. Gladyshev 99

Chapter 10 Deletion of selenoprotein P gene in the mouse / Raymond F. Burk, Gary E. Olsen, Kristina E. Hill 111

Chapter 11 Selenium and methionine sulfoxide reduction / Hwa-Young Kim, Vadim N. Gladyshev 123

Chapter 12 Selenoprotein W in development and oxidative stress / Chrissa Kioussi, Philip D. Whanger 135

Chapter 13 The 15-kDa selenoprotein (Sep15): functional analysis and role in cancer / Vyacheslav M. Labunskyy, Vadim N. Gladyshev, Dolph L. Hatfield 141

Chapter 14 Regulation of glutathione peroxidase-1 expression / Roger A. Sunde 149

Chapter 15 Selenoproteins of the glutathione system / Leopold Flohe, Regina Brigelius-Flohe 161

Chapter 16 New roles of glutathione peroxidase-1 in oxidative stress and diabetes / Xin Gen Lei, Wen-Hsing Cheng 173

Chapter 17 Selenoproteins of the thioredoxin system / Arne Holmgren 183

Chapter 18 Mitochrondrial and cytosolic thioredoxin reductase knockout mice / Marcus Conrad, Georg W. Bornkamm, Marcus Brielmeier 195

Chapter 19 Selenium, deiodinases and endocrine function / Antonio C. Bianco, P. Reed Larsen 207

Chapter 20 Biotechnology of selenium / Linda Johansson, Elias S.J. Arner 221

Part III Selenium and human health

Chapter 21 Selenium, selenoproteins and brain function / Ulrich Schweizer, Lutz Schomberg 233

Chapter 22 Selenium as a cancer preventive agent / Gerald F. Combs, Junxuan Lu 249

Chapter 23 Peering down the kaleidoscope of thiol proteomics and unfolded protein response in studying the anticancer action of selenium / Ke Zu, Yue Wu, Young-Mee Park, Clement Ip 265

Chapter 24 Genetic variation among selenoprotein genes and cancer / Alan M. Diamond, Rhonda L. Brown 277

Chapter 25 Selenium and viral infections / Melinda A. Beck 287

Chapter 26 Role of selenium in HIV/AIDS / Marianna K. Baum, Adriana Campa 299

Chapter 27 Effects of selenium on immunity and aging / Roderick C. McKenzie, Geoffrey J. Becket, John R. Arthur 311

Chapter 28 Selenium and male reproduction / Matilde Maiorino, Antonella Roveri, Fulvio Ursini, Regina Brigelius-Flohe, Leopold Flohe 323

Chapter 29 Mouse models for assessing the role of selenium in health and development / Bradley A. Carlson, Xue-Ming Xu, Rajeev Shrimali, Aniruddha Sengupta, Min-Hyuk Yoo, Nianxin Zhong, Dolph L. Hatfield, Robert Irons, Cindy D. Davis, Byeong Jae Lee|cSergey V. Novoselov, Vadim N. Gladyshev 333

Chapter 30 Drosophila as a tool for studying selenium metabolism and role of selenoproteins / Cristina Pallares, Florenci Serras, Montserrat Corominas 343

Chapter 31 Selenoproteins in parasites / Gustavo Salinas, Alexey V. Lobanov, Vadim N. Gladyshev 355

Chapter 32 Incorporating 'omics' approaches to elucidate the role of selenium and selenoproteins in cancer prevention / Cindy D. Davis, John A. Milner 367

Chapter 33 Selenium-induced apoptosis / Ick Young Kim, Tae Soo Kim, Youn Wook Chung, Daewon Jeong 379

Chapter 34 Selenoprotein mimics / Junqiu Liu, Guimin Luo 387

Chapter 35 Update of human dietary standards for selenium / Orville A. Levander, Raymond F. Burk 399.

Notes:

Includes bibliographical references and index.

ISBN:

0387338268

9780387338262

0387338276

9780387338279

OCLC:

71336450

Publisher Number:

9780387338262