The genetics of male infertility / edited by Douglas T. Carrell.

Format:

Book

Contributor:

Carrell, Douglas T.

Language:

English

Subjects (All):

Infertility, Male--Genetic aspects--Congresses.

Infertility, Male.

Spermatogenesis--Genetic aspects--Congresses.

Spermatogenesis.

Infertility, Male--genetics.

Spermatogenesis--Genetic aspects.

Genetic Techniques.

Medical Subjects:

Infertility, Male--genetics.

Genetic Techniques.

Genre:

Conference papers and proceedings.

Physical Description:

xv, 337 pages : illustrations (some color) ; 24 cm

Place of Publication:

Totowa, N.J. : Humana Press, [2007]

Summary:

Infertility is a common and severe health problem affecting roughly 7% of the male population. It is likely that the majority of those patients have genetic abnormalities that are the cause of their infertility. In The Genetics of Male Infertility, twenty-one researchers and clinicians review the study of the genetics of male infertility, the tools available in the laboratory and clinic, the current state of knowledge, and the future of research and translation into clinical diagnostics and treatments. This volume gives special attention to the significant technological advances in the treatment of male infertility, including intracytoplasmic injection (ICSI) in conjunction with in vitro fertilization (IVF). In addition, new tools discussed include in vitro methodologies, in silico technologies, and new model organisms.

Providing a review of our current understanding of genetic causes of male infertility, The Genetics of Male Infertility serves as a guide to evidence-based clinical applications, and a preview of future possibilities. Features: Comprehensive review of our current understanding of genetic causes of male infertility, Written by world-renown researchers and clinicians in the field, Technological advances in the treatment of male infertility, Discussion of new tools available in the laboratory and clinic.

Contents:

The genetics of male infertility in the era of genomics: tools for progress / Douglas T. Carrell

The use of cDNA libraries to demonstrate a linkage between transcription and translation in male germ cells / Norman B. Hecht

Considerations when using array technologies for male factor assessment / Adrian E Platts, David J. Dix, and Stephen A. Krawetz

Microarray analysis of a large number of single-nucleotide polymorphisms in individual human spermatozoa / Honghua Li ... [et al.]

Physiological and proteomic approaches to understand human sperm function: prefertilization events / Sarah J. Conner ... [et al.]

Genetics of idiopathic male infertility: the power of a cross-species approach / Angshumoy Roy, Yi-Nan Lin, and Martin M. Matzuk

The immunocytogenetics of human male meiosis: a progress report / Daniel Topping, Petrice Brown, and Terry Hassold

The clinical relevance of sperm aneuploidy / Renee H. Martin

DNA repair genes and genomic instability in severe male factor infertility / Francesca K.E. Gordon and Dolores J. Lamb

Germ cell-specific genes and posttranscriptional regulation in the testis / Mark S. Fox and Renee A. Reijo Pera

The genetics of cryptorchidism / Alexander I. Agoulnik and Shu Feng

The chromatoid body and microRNA pathways in male germ cells / Martti Parvinen ... [et al.]

Sperm maturation in the epididymis: role of segment-specific microenvironments / Gail A. Cornwall and Hans H. von Horsten

The structure of the Y chromosome in infertility / Leslie Ayensu-Coker, Collin Bishop and Jan Rohozinski

Y chromosome microdeletions and haplotypes / Ken McElreavey ... [et al.]

The genetics of male infertility: from bench to clinic / David M. de Kretser ... [et al.]

The future of the diagnosis of male (in)fertility / Christopher De Jonge

Polymorphisms and male infertility / Csilla Krausz

The genetics of abnormal protamine expression / Vincent W. Aoki and Douglas T. Carrell

Chromatin damage and male infertility / Denny Sakkas, Davide Bizzaro, and Gian C. Manicardi

Clinical evaluation of the genetics of male infertility / Peter N. Schlegel.

Notes:

Includes bibliographical references and index.

ISBN:

1588298639

9781588298638

1597451762

9781597451765

OCLC:

68980686