Cell communication in nervous and immune system / Eckart D. Gundelfinger, Constanze I. Seidenbecher, Burkhart Schraven (eds.).

Format:

Book

Contributor:

Gundelfinger, Eckart D.

Seidenbecher, Constanze I.

Schraven, Burkhart.

Series:

Results and problems in cell differentiation ; 43.

Results and problems in cell differentiation, 0080-1844 ; 43

Language:

English

Subjects (All):

Neuroimmunology.

Cell Communication--immunology.

Cell interaction.

Nervous system--Immunology.

Nervous system.

Immunology.

Medical Subjects:

Cell Communication--immunology.

Physical Description:

xiv, 313 pages : illustrations ; 25 cm.

Place of Publication:

Berlin ; New York : Springer, [2006]

Summary:

At first glance, the nervous and immune systems appear very different. However, both systems have developed mechanisms for memory formation - though of quite different quality and significance for the organism. One striking example is that both systems form and communicate via synapses armed with similar sets of proteins. This collection of reviews, contributed by internationally recognized immunologists and molecular and cellular neurobiologists, puts side by side cellular communication devices and signaling mechanisms in the immune and nervous systems and discusses mechanisms of interaction between the two systems, the significance of which has only recently been fully appreciated.

Contents:

Molecular Organization and Assembly of the Postsynaptic Density of Excitatory Brain Synapses / Eunjoon Kim, Jaewon Ko 1

2 Components of the PSD 1

3 Assembly of the PSD 3

4 Synaptic Adhesion and PSD Proteins 4

5 Membrane Proteins and PSD Proteins 5

6 Spine Formation and PSD Proteins 5

7 Postsynaptic Signaling and PSD Proteins 7

8 Regulation of Synaptic Transmission and Plasticity by PSD Proteins 9

9 Dynamic Regulation of the Assembly of the PSD 11

10 Transport of PSD Proteins by Motor Proteins 12

Molecular Organization and Assembly of the Central Inhibitory Postsynapse / I. Lorena Arancibia-Carcamo, Stephen J. Moss 25

1.1 Gaba[subscript A] Receptor Structure 26

1.2 Gaba[subscript A] Receptor Localization within the Brain 27

2 Formation and Maintenance of Inhibitory Synapses 30

3 Trafficking and Targeting of GABA[superscript A] Receptors 32

4 Receptor Stability 37

Molecular Organization and Assembly of the Presynaptic Active Zone of Neurotransmitter Release / Anna Fejtova, Eckart D. Gundelfinger 49

2 General Aspects of Structural and Functional Organization of the Active Zone 50

2.1 Neurotransmitter Release 50

2.2 Ultrastructural Organization of the Active Zone 51

3 Molecular Organization of the Active Zone 52

3.1 The UNC13/Munc13 Protein Family - Key Actors in SV Priming 55

3.2 RIMs - Multidomain Rab3 Effectors with a Major Organizing Role 56

3.3 Cast/Erc Proteins - Major Structural Proteins of the Caz? 58

3.4 Piccolo and Bassoon - Two Related Giants Scaffolding the Caz 58

4 Synaptic Ribbons - Specializations of the Caz at High-Throughput Synapses 60

5 Developmental Assembly of the Active Zone - The Active Zone Precursor Vesicle Hypothesis 62

Extracellular Matrix and Synaptic Functions / Alexander Dityatev, Renato Frischknecht, Constanze I. Seidenbecher 69

2 Synaptogenic Activity of Agrin 71

3 Synaptic Functions of Laminins 72

4 Synaptic Functions of Integrins 75

5 Thrombospondins and Synaptogenesis 76

6 Synaptic Functions of Reelin 77

7 Clustering of Glutamate Receptors by Neuronal Pentraxins 79

8 Hb-Gam and N-syndecan in Synaptic Plasticity 80

9 Tenascin-R, Gabaergic Transmission and Metaplasticity 81

10 Tenascin-C and Synaptic Plasticity 83

11 NG2 and Glia-neuron Synapses 84

12 Lecticans Differentially Contribute to Synapse Formation and Function 85

13 Receptor Protein Tyrosin Phosphatase and Phosphacan 87

14 Matrix Metalloproteases and the Modulation of Perisynaptic Matrix 88

Electrical Synapses - Gap Junctions in the Brain / Carola Meier, Rolf Dermietzel 99

2 Gap Junctions in Development 101

3 Gap Junctions in Glial Cells 102

4 Challenges in Expression Analysis of Gap Junction Proteins 104

5 Some History on Electrical Synapses 105

6 Gap Junctions in Neurons - Electrical Synapses 106

6.1 Connexin Gap Junctions 106

6.2 Pannexin Gap Junctions 116

Neuron-Glia Interactions at the Node of Ranvier / Matthew N. Rasband 129

2 Domain Structure of the Myelinated Axon 131

2.1 Node of Ranvier 131

2.2 Paranode 134

2.3 Juxtaparanode 135

3 Examples of Neuron-Glia Interactions 136

3.1 Neuron-Glia Interactions Regulate Nav Channel Clustering at Nodes of Ranvier 137

3.2 Neuron-Glia Interactions at the Paranode 140

3.3 Neuron-Glia Interactions Regulate Juxtaparanodal K[superscript +] Channel Localization 142

Cognate Interaction Between Endothelial Cells and T Cells / Percy A. Knolle 151

1 Organ-Specific Phenotypes and Functions of Endothelial Cells 151

2 Establishment of Interaction Between Endothelial Cells and T Cells 154

3 Endothelial Cells as Antigen-Presenting Cells 155

4 MHC Expression and Antigen Presentation by Endothelial Cells 155

5 Co-stimulation by Endothelial Cells 158

6 Consequences of Cognate Interaction Between Antigen-Presenting Endothelial Cells and T Cells 159

7 Modulation of CD8 T Cell Function by Endothelial Cells 161

8 Modulation of CD4 T Cell Function 163

9 Transmigration of T Cells in Response to Antigen Presentation by Endothelial Cells 164

10 Mediation of Antigen-Specific T Cell Recruitment in the Absence of Antigen Presentation by Endothelial Cells 167

Impact of the Immunological Synapse on T Cell Signaling / Michael L. Dustin 175

2 New Model for Sustained Signaling Through the Immunological Synapse 177

3 In Vivo Functions of Immunological Synapse and Hemisynapse 183

4 In Vivo Analysis of CD4[superscript +] T Cell Priming and Tolerance Induction 184

5 In Vivo Analysis of CD8[superscript +] T Cell Priming and Tolerance Induction 187

6 Importance of Stable Interactions In Vivo 189

7 Effector Sites 190

The Biophysics of T Lymphocyte Activation In Vitro and In Vivo / Peter Reichardt, Matthias Gunzer 199

2 The Role of T Cells Within the Immune System: A T Cell Biography 201

2.1 T Cell Selection in the Thymus 201

2.2 T Cell Circulation and Homeostasis 202

2.3 T Cell Activation in the Lymph Node: A Marketplace Analogy 202

2.4 Homing of Activated T Cells 205

2.5 T Cell Regulation 206

3 The Biophysics of T Cell Activation 206

3.1 Classical In Vitro Studies of T Cell-APC Interaction 207

3.2 The Single Encounter Model of T Cell Activation 208

3.3 Challenges Introduced by Live Cell Imaging Experiments 208

3.4 A Serial Encounter Model of T Cell Activation 210

3.5 The Road to Intravital Imaging: Phase Models of T Cell Activation 210

3.6 The Role of the APC 212

3.7 Summary: A Multitude of T Cell-APC Interaction Kinetics 212

Molecular Regulation of Cytoskeletal Rearrangements During T Cell Signalling / Theresia E. B. Stradal, Rico Pusch, Stefanie Kliche 219

1.1 The Actin Cytoskeleton 220

1.2 The Microtubule System 221

2 Arp2/3-Dependent Actin Assembly and the WASP/Scar Family of Proteins 223

2.1 Wasp and the Wiskott-Aldrich Syndrome 223

2.2 Wave Proteins Induce Actin Assembly Downstream of Rac 225

3 T Cell Signalling Leading to Cytoskeletal Rearrangements 226

3.1 T Cell Migration 226

3.2 Immunological Synapse Formation/TCR Signalling 229

4 Conclusions and Outlook 234

Membrane-Proximal Signaling Events in Beta-2 Integrin Activation / Bettina Kellersch, Waldemar Kolanus 245

2 The Integrin Cytoskeletal Anchor Talin 247

3 Rap1 and RAPL Control Cell Adhesion 247

4 DNAM-1 249

5 SKAP-55 and ADAP/Fyb/SLAP-130 250

6 Cytohesins, Cytohesin-binding Proteins, Integrins and the Cytoskeleton 251

7 Cytohesins in Downstream Signaling and Gene Activation Events 253

Regulation of Immune Cell Entry into the Central Nervous System / Britta Engelhardt 259

1 The Immune Privilege of the CNS Reconsidered 259

2 Where do Immune Cells Enter the Immune Privileged CNS? 260

3 How do Immune Cells Leave the Bloodstream and Enter the Tissue? 262

4 The Challenges of Studying Leukocyte Trafficking into the CNS 264

5 Immunosurveillance of the CNS: Immune Cell Entry into the Healthy CNS 265

6 Immune Cell Migration Across the Inflamed BBB 267

6.1 Tethering and Rolling Versus Capture 268

6.2 G-Protein Signalling 269

6.3 Firm Adhesion 270

6.4 Diapedesis: Transcellular or Paracellular? 271

Cell-cell communication by Endocannabinoids during Immune Surveillance of the Central Nervous System / Oliver Ullrich, Regine Schneider-Stock, Frauke Zipp 281

1 Keeping Control: CNS Immune Surveillance 281

2 Loosing Control: Inflammatory Escalation during Multiple Sclerosis 283

3 Maintaining the Balance: The Brain Endocannabinoid System 285

3.1 Endogenous Ligands 285

3.2 Release, Uptake and Deactivation 287

3.3 Signal Transduction 288

3.4 Cell-Cell-Communication 289

4 Gaining Control: Therapeutic Intervention in CNS Inflammation 292

4.1 Microglia as Therapeutic Target 292

4.2 Cannabinoid System as Therapeutic Target 293.

Notes:

Includes bibliographical references and index.

ISBN:

3540368280

OCLC:

72867753

Publisher Number:

9783540368281