A handbook of mouse models of cardiovascular disease / editor, Qingbo Xu.

Format:

Book

Contributor:

Xu, Qinbo.

Language:

English

Subjects (All):

Cardiovascular system--Diseases--Animal models.

Cardiovascular system.

Mice--Diseases--Pathophysiology.

Mice.

Cardiovascular Diseases.

Disease Models, Animal.

Mice--Diseases.

Physiology, Pathological.

Cardiovascular system--Diseases.

Medical Subjects:

Cardiovascular Diseases.

Disease Models, Animal.

Mice.

Genre:

Handbooks and manuals.

Physical Description:

xvi, 387 pages : illustrations ; 25 cm + 1 CD-ROM (4 3/4 in.)

4 3/4 in.

polychrome

Place of Publication:

Chichester, England ; Hoboken, NJ : John Wiley & Sons, [2006]

System Details:

text file

Summary:

Accompanying CD-ROM contains ... "color versions of figures from the book for increased clarity. Importantly, each technique is clearly illustrated on the accompanying CD, so that researchers can observe the operational procedures directly."--P. [4] of cover.

Contents:

1 Mice - general information / Hermann Dietrich 1

Historical perspective of house mice as laboratory animals 1

Maintaining and breeding of mice 3

Blood and bone marrow collection methods 7

Anesthesia and analgesia 7

Euthanasia 14

2 Naturally occurring variation among mouse strains / Weibin Shi, Aldons J. Lusis 19

Mapping genes underlying quantitative traits 20

Dissecting QTLs using congenic strains 22

Testing candidate genes in QTL regions 24

Functional tests of candidate genes 26

From mouse to man 28

3 Transgenic and gene-targeted mice in the study of hyperlipidemia / Yadong Huang 33

Generation of transgenic mouse models 34

Generation of gene-targeted mouse models 36

Application of transgenic and gene-targeted mouse models in hyperlipidemia research 38

4 Bone marrow transplantation: the methodology and its application in atherosclerosis research / Menno P.J. de Winther, Marten H Hofker 43

Discussion and application 48

5 Hyperlipidemia-induced atherosclerosis / Alan Daugherty, Debra L. Rateri 53

Induction of hyperlipidemia in mice 54

Mouse strain 56

Environmental factors 57

Gender 57

Analysis of atherosclerotic lesions 57

Determination of lesion composition 62

Statistical analysis 63

6 Magnetic resonance imaging evaluation of atherosclerotic plaque / Martina A. McAteer, Jurgen E. Schneider, Robin P. Choudhury 67

Imaging atherosclerosis with MRI 68

Mouse MRI 68

Materials and methods 69

Application 76

7 Plaque rupture / Christopher L. Jackson 79

Animals 79

Husbandry and welfare 81

Termination 81

Tissue processing 82

Morphological analysis 83

Morphometric analysis 84

Study design considerations 85

8 Perivascular cuff-, electronic and chemical injury-induced stenosis / Nuno M.M. Pires, Margreet R. de Vries, Abbey Schepers, Daniel Eefting, Jan-Willem H.P. Lardenoye, Paul H.A. Quax 89

Materials and methods 92

Application 94

9 Flow-induced vascular remodeling / Vyacheslav A. Korshunov, Bradford C. Berk 103

Materials and methods 104

Applications 108

Movie legends 111

10 Vein graft atherosclerosis / Yanhua Hu, Qingbo Xu 113

Materials and methods 114

Applications 120

11 Angiotensin II-induced aortic aneurysms / Yi-Xin Wang, Lisa A. Cassis, Alan Daugherty 125

12 Carotidojugular fistula / Yves Castier, Alain Tedgui, Stephanie Lehoux 137

Creation of the AVF 138

Hemodynamic and structural data 142

13 Applications to the study of stroke / Jacques Seylaz, Elisabeth Pinard 147

Experimental preparation of mice 148

Applications 155

14 Identifying congenital heart defects in embryos using high-resolution magnetic resonance imaging / Jurgen E Schneider, Shoumo Bhattacharya 159

Identifying mouse cardiac malformations 160

Magnetic resonance imaging 160

Embryo MRI technique and analysis 161

Applications 166

Pros and cons of ex vivo MRI 169

15 Allograft arteriopathy: heterotopic heart transplantation and aortic interposition grafts / Koichi Shimizu, Richard N. Mitchell 173

Murine models for AA 175

Murine heterotopic cardiac transplantation 177

Murine aortic interposition grafts 183

Translation to clinical investigation 187

16 Heart preconditioning analysis / Guang-Wu Wang, David A Liem, Steven Le, Peipei Ping 193

Methodological considerations 198

17 Myocardial ischemia-reperfusion / Bernhard Metzler, Elisabetta Conci, Otmar Pachinger 203

Myocardial ischemia-reperfusion 203

Ischemia-reperfusion models 206

Measurement of infarction size 210

Electrocardiogram and in vivo left ventricular pressure-volume measurements 214

Different mouse types 215

18 Cardiac hypertrophy / David J. Grieve, Alison C. Cave, Ajay M. Shah 221

Materials and methods 222

19 The retrogradely perfused isolated heart model / Mihaela M. Mocanu, Derek M. Yellon 235

Langendorff system 235

Preparation of hearts for perfusion 237

Experimental protocol 241

Measurement of infarct size 242

Infarct size computation 243

20 Measurement of pulse wave velocity / Yi-Xin Wang 245

Materials and methods 246

Application 251

21 Gene transfer to dyslipidemic mice / Kazuhiro Oka, Andrew H. Baker, Lawrence Chan 255

Mouse models of dyslipidemia 256

ApoB transgenic mice 263

Vectors for liver-directed gene transfer 263

Route or vector delivery 267

22 Hypertension / Daiana Weiss, W. Robert Taylor 273

Pharmacological models of hypertension 275

Renal models of hypertension 278

Genetic models of hypertension 279

Measurement of blood pressure in mice 282

23 Ischemia-induced neovascularisation / Ken-ichiro Sasaki, Christopher Heeschen, Alexandra Aicher, Stefanie Dimmeler 287

Materials and methods 288

Application 296

24 Angiogenesis in biomatrices and artificial materials / Pieter Koolwijk, Victor W.M. van Hinsburgh 299

Materials and methods 300

Application 307

25 Venous thrombosis / Alberto Smith, James Gossage, Matthew Waltham, Bijan Modarai, Julie Humphries 311

Models of thrombosis 313

The St Thomas' model 314

26 Virus-induced vasculitis / Philippe Krebs, Burkhard Ludewig 321

Materials and methods 322

Application 329

27 Surgically induced chronic heart failure / Craig A. Lygate, Stefan Neubauer 333

Materials and methods 336

Applications 346

28 Cardiac electrophysiology / Sander Verheule, Toshiaki Sato, Jeffrey E. Olgin 349

Anesthesia for adult mice 350

ECG recording and analysis 351

Transesophageal stimulation 352

Open chest epicardial measurements 354

Studies on Langendorff perfused hearts 357

29 Ligation- and wire injury-induced stenosis / Volkhard Lindner 363

Materials and methods 364.

Notes:

Includes bibliographical references and index.

ISBN:

0470016108

OCLC:

69391395

Publisher Number:

9780470016107 (alk. paper)