Amyotrophic lateral sclerosis / edited by Robert H. Brown Jr., Michael Swash, Piera Pasinell.

Format:

Book

Contributor:

Brown, Robert H., Jr., 1947-

Swash, Michael.

Pasinelli, Piera, 1966-

Language:

English

Subjects (All):

Amyotrophic lateral sclerosis.

Amyotrophic Lateral Sclerosis.

Medical Subjects:

Amyotrophic Lateral Sclerosis.

Physical Description:

xxi, 370 pages, 7 unnumbered pages of plates : illustrations (partly color) ; 26 cm

Edition:

Second edition.

Place of Publication:

Abingdon [England] : Informa Healthcare ; Boca Raton, FL : Distributed in North America by Taylor & Francis, 2006.

Summary:

Amyotrophic lateral sclerosis or motor neuron disease is one of the most debilitating and devastating of the neurological diseases. This second edition of Amyotrophic Lateral Sclerosis, is a reorganization and revision of the highly successful first edition, and examines all aspects of the condition from its pathology to patient care. Other topics covered include: Neurophysiology and neuropsychology of ALS, Functional MRI in ALS, The genetics of motor neuron disease, Pathogenic mechanisms: cell death pathways, aging and neurodegeneration, mitochondrial dysfunction, Palliative care and quality of life of patients with ALS.

The editors, Robert H Brown Jr, Michael Swash and Piera Pasinelli have assembled an outstanding team of global contributors, thus providing the reader with a ready and accurate reference to help with all aspects of the relentless difficulties encountered in patient diagnosis and treatment. Undoubtedly an important work in its field, this book will be of great interest to clinical neurologists and trainees, and to all those concerned with the care of people with ALS.

Contents:

Section 1 Clinical data 1

1 The spectrum of motor neuron disorders / Brian Murray, Hiroshi Mitsumoto 3

2 Epidemiology of amyotrophic lateral sclerosis / Lorene M Nelson, Valerie McGuire 25

Section 2 Functional studies 43

3 Neuroimaging in amyotrophic lateral sclerosis / Martin R Turner, Victoria Williams, Camilla Blain, Derek Jones, Blaz Koritnik, P Nigel Leigh 45

4 Motor unit number estimation in amyotrophic lateral sclerosis / Devanand Jillapalli, Jeremy M Shefner 69

5 The corticomotoneuronal system in amyotrophic lateral sclerosis / Markus Weber 83

6 Conventional neurophysiology in amyotrophic lateral sclerosis / Mamede de Carvalho, Michael Swash 105

7 The neuropsychology of amyotrophic lateral sclerosis / Jennifer Murphy, Cathy Lomen-Hoerth 125

Section 3 Genetics of amyotrophic lateral sclerosis and related disorders 139

8 Familial motor neuron diseases other than amyotrophic lateral sclerosis / Alice Brockington, Pamela J Shaw 141

9 Amyotrophic lateral sclerosis genetics with Mendelian inheritance / Peter M Andersen 187

10 Modifying genes in amyotrophic lateral sclerosis / Claire L Simpson, Ammar Al-Chalabi 209

11 From genetic defects to molecular pathogenesis of memory and movement disorders / William H Stoothoff, Bradley T Hyman 225

Section 4 Pathogenic mechanisms 239

12 Transgenic mouse and mutagenesis models / Ludo Van Den Bosch, Wim Robberecht 241

13 Apoptotic cell death pathways in amyotrophic lateral sclerosis: a review / Piera Pasinelli, Robert H Brown Jr 257

14 Amyotrophic lateral sclerosis and neurodegeneration: possible insights from the molecular biology of aging / Anne-Marie A Wills, Robert H Brown Jr 269

15 Neurotrophic factors / Michael Sendtner 283

16 Axonal transport and amyotrophic lateral sclerosis / Andy Grierson, Chris Miller 309

17 Mitochondrial dysfunction and energy metabolism in amyotrophic lateral sclerosis / Giovanni Manfredi, M Flint Beal 323

Section 5 Therapy of amyotrophic lateral sclerosis and related disorders 333

18 Therapeutic trials in amyotrophic lateral sclerosis: past, present and future / Jacqueline Lau, Robin Conwit, Robert Miller, Merit Cudkowicz 335

19 Palliative care and quality of life in amyotrophic lateral sclerosis / David Oliver, Gian Domenico Borasio 357.

Notes:

"First published in the United Kingdom in 2000 by Martin Dunitz Ltd."--T.p. verso.

Includes bibliographical references and index.

ISBN:

1841844632

OCLC:

60965654

Publisher Number:

9781841844633 (hbk.)