Animal models of cognitive impairment / edited by Edward D. Levin, Jerry J. Buccafusco.

Format:

Book

Contributor:

Levin, Edward D.

Buccafusco, Jerry J.

Series:

Frontiers in neuroscience (Boca Raton, Fla.)

Frontiers in neuroscience

Language:

English

Subjects (All):

Cognition disorders--Animal models.

Cognition disorders.

Physical Description:

376 pages : illustrations ; 25 cm.

Place of Publication:

Boca Raton : CRC Taylor & Francis, 2006.

Summary:

Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairment examines some of the most popular and successful animal archetypes used in the context of drug discovery. It provides integrated coverage of the latest research concerning neuronal systems relevant to cognitive function and dysfunction, assimilating reviews of this research within the context of each chapter. This approach is unique in that it brings together molecular and neurochemical methodologies, behavioral applications in translational models, and clinical applications.

The book comprehensively discusses a wide variety of animal models of cognitive impairment, including genetic, lesion, pharmacological, and aging related impairments. It also explores the significance of this research in regards to the treatment of various addictions and disorders such as stroke, autism, Alzheimer's, schizophrenia, and ADHD.

Edited by two renowned authorities in the field, Animal Models of Cognitive Impairment is a timely book that provides integrated coverage of cutting-edge research that concerns neuronal systems relevant to cognitive function and dysfunction.

Contents:

Section I Pharmacologic Models

Chapter 2 Muscarinic Receptor Antagonists in Rats / Alvin V. Terry, Jr. 5

Chapter 3 Nicotinic Receptor Antagonists in Rats / Cindy S. Roegge, Edward D. Levin 21

Chapter 4 Involvement of the NMDA System in Learning and Memory / Amir H. Rezvani 37

Chapter 5 Animal Models and the Cognitive Effects of Ethanol / Merle G. Paule 49

Section II Toxicologic Models

Chapter 6 Animal Models of Cognitive Impairment Produced by Developmental Lead Exposure / Deborah C. Rice 73

Chapter 7 Developmental Behavioral Toxicity of Methylmercury: Consequences, Conditioning, and Cortex / M. Christopher Newland, Wendy D. Donlin, Elliott M. Paletz, Kelly M. Banna 101

Chapter 8 Executive Function following Developmental Exposure to Polychlorinated Biphenyls (PCBs): What Animal Models Have Told Us / Helen J.K. Sable, Susan L. Schantz 147

Chapter 9 Modeling Cognitive Deficits Associated with Parkinsonism in the Chronic-Low-Dose MPTP-Treated Monkey / J.S. Schneider 169

Section III Mouse Genetic Models

Chapter 10 Cognitive Impairment in Transgenic Mouse Models of Amyloid Deposition / Dave Morgan 183

Chapter 11 Cholinergic Receptor Knockout Mice / Lu Zhang 199

Chapter 12 Assessments of Cognitive Deficits in Mutant Mice / Ramona Marie Rodriguiz, William C. Wetsel 223

Section IV Model Applications and Future Developments

Chapter 13 Cognitive Pharmacology in Aging Macaques / Jerry J. Buccafusco 285

Chapter 14 Cognitive Impairment following Traumatic Brain Injury / Mark D. Whiting, Anna I. Baranova, Robert J. Hamm 301

Chapter 15 Cognitive Impairment Models Using Complementary Species / Daniel T. Cerutti, Edward D. Levin 315

Chapter 16 Cognition Models and Drug Discovery / Michael W. Decker 343.

Notes:

Includes bibliographical references and index.

ISBN:

0849328349

OCLC:

64625023

Publisher Number:

9780849328343

Online:

Publisher description