Carcinoma of an unknown primary site / edited by Karim Fizazi.

Format:

Book

Contributor:

Fizazi, Karim.

Language:

English

Subjects (All):

Cancer of unknown primary origin.

Neoplasms, Unknown Primary--diagnosis.

Carcinoma--diagnosis.

Carcinoma--therapy.

Neoplasms, Unknown Primary--therapy.

Medical Subjects:

Neoplasms, Unknown Primary--diagnosis.

Carcinoma--diagnosis.

Carcinoma--therapy.

Neoplasms, Unknown Primary--therapy.

Physical Description:

xv, 240 pages : illustrations ; 24 cm

Place of Publication:

New York : Taylor & Francis, 2006.

Summary:

Filling a gap in the literature, this guide provides expert recommendations and research on carcinoma of an unknown primary site (CUP). Covering the identification, diagnosis, and management of CUP with illustrative and reader-friendly clinical case examples, this reference helps physicians treat patients whose primary cancer site is difficult to locate and asses. The only book available on the subject, this source features a series of 10 clinical cases that include both common and unusual presentations of carcinomas of an unknown primary...contains clear care guidelines for cancer physicians treating patients with CUP...reviews the utilization and impact of chemotherapy in the care of CUP patients...considers the surgical management of CUP...and presents international perspectives from professionals at varied institutions to provide a balanced overview of each subject discussed in the text.

Contents:

Section I Carcinomas of Unknown Primary Site: Several Things We Know for Sure

1 What We Know About Carcinomas of Unknown Primary Site (CUP) Almost for Sure: Incidence, Survival, and Necropsy Data / Agnes J. Van de Wouw, Agnes Laplanche 1

Incidence and Mortality 2

Clinical Behavior of CUP 5

Autopsy Data 6

Survival 7

Section II Diagnostic Evaluation in Carcinomas of Unknown Primary Site: What Shall We Do and When Shall We Stop Seeking the Primary Site?

2 Radiographic Studies, Endoscopy, and Serum Tumor Markers in the Diagnostic Evaluation of Carcinomas of Unknown Primary Site / Gauri R. Varadhachary, Renato Lenzi 11

Chest X Ray 13

Computed Axial Tomography 14

Contrast Studies of the GI Tract and Endoscopic Procedures 16

Serum Tumor Markers 18

Survival Patterns and Their Effect on Diagnostic Strategies in Patients Presenting with Occult Primary Cancer 19

Conclusion and Future Directions 21

3 The Advent of Immunohistochemistry in Carcinoma of Unknown Primary Site: A Major Progress / Jean-Jacques Voigt, Marie-Christine Mathieu, Frederic Bibeau 25

Strategies for Specific Histopathological Types 30

Strategies Depending on Anatomic Localization 32

Targeted Treatment of CUP 32

4 The Importance of Identifying CUP Subsets / Nicholas Pavlidis, Yacine Merrouche 37

Histopathological Subtypes 38

Clinicopathological Entities 39

Favorable Subsets 40

Unfavorable Subsets 43

Section III Emerging Diagnostic Tools

5 Role of Positron Emission Tomography with 18F-Fluorodesoxyglucose (PET-FDG) in the Care of Carcinomas of an Unknown Primary Site / Etienne Garin, Dirk Rades 49

PET-FDG and Cervical Metastases of Unknown Primary 51

PET-FDG and CUP Not Targeted on Cervical Metastases 55

Section IV Prognostic Factors

6 Prognostic Considerations in Patients with Unknown Primary Carcinoma / Renato Lenzi, Stephane Culine 61

Prognostic Factors in UPC Patients with PDC and PDA 63

Prognostic Factors in the General Population of UPC Patients 68

Prognostic Factors and UPC Clinical Trials 73

Section V Systemic Chemotherapy

7 Treatment of Patients with Favorable Subsets of Unknown Primary Carcinoma / John D. Hainsworth 79

Women with Peritoneal Carcinomatosis 79

Women with Axillary Lymph Node Metastases 81

Adenocarcinoma Presenting as a Single Metastatic Lesion 81

Young Men with Features of Extragonadal Germ Cell Tumor 82

Squamous Carcinoma Involving Cervical Lymph Nodes 82

Squamous Carcinoma Involving Inguinal Lymph Nodes 83

Neuroendocrine Carcinoma with an Unknown Primary Site 84

Poorly Differentiated Carcinoma 86

8 Chemotherapy for Patients with Metastatic Carcinoma of Unknown Primary Site / F. Anthony Greco, Stephane Culine 93

Historical Background 94

The Minnie Pearl Cancer Research Network Experience 95

The French Experience 95

At the End, Does Chemotherapy Improve Survival? 98

9 Randomized Trials in Patients with Carcinoma of an Unknown Primary Site: The Past, the Present, and the Future / Karim Fizazi, Hans-Joachim Schmoll 105

Results 110

Section VI Local Treatments in Carcinoma of Unknown Primary Site: Is It Relevant?

10 Squamous Cell Carcinoma of an Unknown Primary Tumor Located in the Cervical Lymph Nodes / Marie-Christine Kaminsky, Emmanuel Blot 117

Epidemiology 118

Patient Work-Up 118

The Role of PET 119

Staging 120

Prognosis 120

Treatment 121

Follow-Up 122

11 Women with Isolated Adenocarcinoma in the Axillary Lymph Node of an Unknown Primary Site / A. Lortholary, C. El Kouri, J. F. Ramee, P. Kerbrat 127

Incidence 128

Presentation 128

Para-Clinical Examinations 128

Treatment 129

Prognosis 130

12 Carcinoma of Unknown Primary in a Single Site / Thierry Lesimple, Carmen Balana 133

Differential Diagnosis and Paraclinic Investigations 134

Localized Lymph-Node Metastases of a CUP 135

Liver Metastasis from a CUP in a Single Site 137

Isolated Bone Metastasis 138

Solitary Pulmonary Nodule from a CUP 139

Localized Pleural Effusion of a CUP 140

Single Cerebral Metastasis of a CUP 141

Metastasis of Cutaneous or Soft Tissues from a CUP 143

13 Emerging Local Treatments in Carcinomas of an Unknown Primary Site: Radiofrequency, Palliative Bone Surgery, and Radiotherapy / D. Pasquier, E. Lartigau, F. Bonodeau, G. Missenard, C. Court, B. Meunier 147

Radiofrequency 148

Palliative Bone Surgery 149

Radiotherapy 153

Section VII The Biology of Carcinoma of Unknown Primary Site

14 The Biology of Unknown Primary Tumors: The Little We Know, the Importance of Learning More / Pierre Busson, Leela Daya-Grosjean, Nicholas Pavlidis, Agnes J. Van de Wouw 159

Nosological Considerations 160

Research Aims and Instruments 161

Brief Summary of Current Knowledge on the Metastatic Phenotype 163

Specific and Nonspecific Biological Features of UPTs 164

What Is the p53 Status in UPTs? 165

Acquisition of the Metastatic Phenotype in UPTs: From Speculation to Testable Hypotheses 166

The Enigma of Primary Tumor Growth Inhibition 167

Search for Prognostic Biological Indicators and Assessment of Potential Molecular Targets 169

Section VIII Quality of Life and Psychosocial Aspects

15 Psychosocial Aspects of Cancer of Unknown Primary Site / Renato Lenzi, Walter F. Baile, Chantal Rodary, Patricia A. Parker 175

Psychosocial Adjustment and Cancer 177

Assessment and Prevalence of Psychosocial Distress in Patients with Known Primary Cancers and in Patients with CUP 178

Aspects of Psychosocial Adjustment in CUP Patients: Illness Uncertainty, Depression, Anxiety, and Perception of Physician's Supportive Behavior 179

QOL Instruments in CUP 181

Diagnosis, Prognosis, and Treatment Plan: Preliminary Findings in CUP Patients 182

Challenging Physician-Patient Communication Tasks in CUP 183

Section IX Clinical Cases of Carcinoma of Unknown Primary Site

Case 1 A Female Patient with Pleural Extension of an Unknown Primary Carcinoma / Karim Fizazi 195

Case 2 A Favorable Case of CUP with Peritoneal Adenocarcinomatosis / Nicholas Pavlidis 199

Case 3 Clear Cell Adenocarcinoma Presenting as a Carcinoma of Unknown Primary Origin / Carmen Balana, Eva Castella, Rafael Rosell 201

Case 4 A Female Patient with a Single-Site Carcinoma of an Unknown Primary Located on the Thoracic Wall / Karim Fizazi, Sylvie Bonvalot 208

Case 5 An Unfavorable Case of CUP with Metastatic Adenocarcinoma to the Liver and Bones / Nicholas Pavlidis 211

Case 6 A Favorable Case of CUP with Metastatic Adenocarcinoma of the Liver with Neuroendocrine Differentiation / Nicholas Pavlidis 214

Case 7 Carcinoma or Melanoma of an Unknown Primary? / Emmanuel Blot, Sophie Laberge-Le-Couteulx 216

Case 8 A Male Patient with HIV Infection and Carcinoma of an Unknown Primary Site / Roland Bugat 218

Case 9 A 66-Year-Old Male with Liver Metastases of an Unknown Primary Site / Roland Bugat 223

Case 10 An Undifferentiated Carcinoma of an Unknown Primary of the Middle Line in a Young Adult / Roland Bugat 221

Case 11 A Female with Bone Metastases of an Unknown Primary Site / Roland Bugat 231.

Notes:

Includes bibliographical references and index.

ISBN:

0824727991

OCLC:

62736851

Publisher Number:

9780824727994