The serotonin receptors : from molecular pharmacology to human therapeutics / edited by Bryan L. Roth.

Format:

Book

Contributor:

Roth, Bryan L.

Series:

Receptors (Series)

The receptors

Language:

English

Subjects (All):

Serotonin--Receptors.

Serotonin.

Serotonin--Physiological effect.

Serotoninergic mechanisms.

Receptors, Serotonin--physiology.

Serotonin Agents.

Medical Subjects:

Receptors, Serotonin--physiology.

Serotonin Agents.

Physical Description:

xvii, 618 pages, 4 unnumbered pages of plates : illustrations (partly color) ; 24 cm.

Place of Publication:

Totowa, N.J. : Humana Press, [2006]

Summary:

A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.

Notes:

Includes bibliographical references and index.

ISBN:

1588295680

OCLC:

61859849

Publisher Number:

9781588295682