The hereditary basis of rheumatic diseases / Rikard Holmdahl editor.

Format:

Book

Contributor:

Holmdahl, Rikard, 1953-

Series:

PIR (Series)

Progress in inflammation research

Language:

English

Subjects (All):

Rheumatism--Genetic aspects.

Rheumatism.

Rheumatic Diseases--genetics.

Medical Subjects:

Rheumatic Diseases--genetics.

Physical Description:

ix, 178 pages : illustrations ; 24 cm.

Place of Publication:

Basel ; Boston : Birkhäuser, [2006]

Summary:

Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part deals with the shared heredity of rheumatic diseases, e.g., RA, lupus and ankylosing spondylitis. The third part of the volume describes tools for analysing genetic complexity, ranging from animal models to new molecular tools. The volume is essential reading for researchers and clinicians from rheumatology, inflammation research, immunology, and cell and molecular biology.

Contents:

Genetics of joint inflammation - problems and possibilities / Rikard Holmdahl 3

B Genetic studies on rheumatic diseases

The epidemiology of rheumatoid arthritis and the use of linkage and association studies to identify disease genes / Jane Worthington, Anne Barton, Sally L. John 9

Heterogeneity in rheumatoid arthritis based on expression analysis: towards personalised medicine / Cornelis L. Verweij, Tineke C.T.M. van der Pouw Kraan 29

Gene-based large scale LD-mapping of rheumatoid arthritisassociated genes / Ryo Yamada, Kazuhiko Yamamoto 43

C Shared heredity of rheumatic diseases

Emerging relationships: rheumatoid arthritis and the PTPN22 associated autoimmune disorders / Peter K. Gregersen, Robert M. Plenge 61

Shared genes in rheumatic diseases, the role of PD1 and the RUNX genes in disease susceptibility / Marta E. Alarcon-Riquelme, Sergey V. Kozyrev 79

The role of B27 and other genes associated with ankylosing spondylitis / Joachim Sieper, Martin Rudwaleit 89

D Tools for analysing complexity

Emerging tools for dissecting complex disease / Ulf D. Landegren 107

Expression analysis of rheumatic diseases, prospects and problems / Thomas Haupl, Andreas Grutzkau, Joachim Grun, Andreas Radbruch, Gerd-R. Burmester 119

The use of humanized MHC mouse strains for studies of rheumatic diseases / Kary A. Latham, Timothy D. Kayes, Zhaohui Qian, Edward F. Rosloniec 131

SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells / Shimon Sakaguchi, Takeshi Takahashi, Hiroshi Hata, Hiroyuki Yoshitomi, Satoshi Tanaka, Keiji Hirota, Takashi Nomura, Noriko Sakaguchi 147

A genetic approach to select and validate new targets for treatment of rheumatic diseases / Peter J. Olofsson 161.

Notes:

Includes bibliographical references and index.

ISBN:

376437201X

3764374195

OCLC:

63297915

Publisher Number:

9783764372019

9783764374198