Histology : a text and atlas : with correlated cell and molecular biology / Michael H. Ross, Wojciech Pawlina.

Format:

Book

Author/Creator:

Ross, Michael H.

Contributor:

Pawlina, Wojciech.

Anne and Joseph Trachtman Memorial Book Fund.

Clarence J. Marshall Memorial Library Fund.

Language:

English

Subjects (All):

Histology.

Histology--Atlases.

Medical Subjects:

Histology.

Genre:

Atlases.

Physical Description:

xvii, 906 pages : illustrations (some color) ; 28 cm + 1 CD-ROM (color ; 4 3/4 in.)

Edition:

Fifth edition.

Place of Publication:

Baltimore, MD : Lippincott Wiliams & Wilkins, [2006]

Summary:

Accompanying CD-ROM contains ... "interactive atlas ..."--CD-ROM label.

Contents:

1 Methods 1

Overview of Methods Used in Histology 1

Tissue Preparation 2

Histochemistry and Cytochemistry 3

Microscopy 12

Box 1.1 Clinical Correlation: Frozen Sections 4

Box 1.2 Functional Considerations: Feulgen Microspectrophotometry 7

Box 1.3 Clinical Correlation: Monoclonal Antibodies in Medicine 9

Box 1.4 Proper Use of the Light Microscope 14

Box 1.5 Functional Considerations: Development of Electron Microscopy 20

2 The Cell Cytoplasm 23

Overview of the Cell and Cytoplasm 23

Membranous Organelles 25

Nonmembranous Organelles 55

Inclusions 68

Cytoplasmic Matrix 69

Box 2.1 Clinical Correlation: Lysosomal Storage Diseases 44

Box 2.2 Clinical Correlation: Abnormalities in Microtubules and Filaments 63

3 The Cell Nucleus 71

Overview of the Nucleus 71

Nuclear Components 72

Cell Renewal 80

Cell Cycle 80

Cell Death 88

Box 3.1 Clinical Correlation: Cytogenetic Testing 76

Box 3.2 Clinical Correlation: Regulation of Cell Cycle and Cancer Treatment 83

4 Tissues: Concept and Classification 92

Overview of Tissues 92

Epithelium 92

Connective Tissue 93

Muscle Tissue 93

Nerve Tissue 94

Identifying Tissues 96

Box 4.1 Clinical Correlation: Ovarian Teratomas 96

5 Epithelial Tissue 98

Overview of Epithelial Structure and Function 98

Classification of Epithelium 99

Cell Polarity 100

The Apical Domain and Its Modifications 102

The Lateral Domain and Its Specializations in Cell-to-Cell Adhesion 108

The Basal Domain and Its Specializations in Cell-to-Extracellular Matrix Adhesion 121

Glands 132

Histogenesis of Epithelium 135

Epithelial Cell Renewal 137

Box 5.1 Clinical Correlation: Primary Ciliary Dyskinesia 107

Box 5.2 Clinical Correlation: Junctional Complexes as a Target of Pathogenic Agents 112

Box 5.3 Functional Considerations: Basement Membrane and Basal Lamina Terminology 123

Box 5.4 Functional Considerations: Mucous and Serous Membranes 138

Atlas Plates

Plate 1 Simple Squamous and Cuboidal Epithelia 140

Plate 2 Simple and Stratified Epithelia 142

Plate 3 Stratified Epithelia and Epithelioid Tissues 144

6 Connective Tissue 146

General Structure and Function of Connective Tissue 146

Embryonic Connective Tissue 147

Connective Tissue Proper 148

Connective Tissue Fibers 149

Extracellular Matrix 161

Connective Tissue Cells 166

Box 6.1 Clinical Correlation: Collagenopathies 158

Box 6.2 Clinical Correlation: Fibrillin Microfilaments and Sun Exposure 161

Box 6.3 Functional Considerations: The Mononuclear Phagocytotic System 170

Plate 4 Loose and Dense Connective Tissue 176

Plate 5 Dense Regular Connective Tissue, Tendons, and Ligaments 178

Plate 6 Elastic Fibers and Elastic Lamellae 180

7 Cartilage 182

Overview of Cartilage 182

Hyaline Cartilage 182

Elastic Cartilage 190

Fibrocartilage 190

Chondrogenesis and Cartilage Growth 191

Repair of Hyaline Cartilage 192

Box 7.1 Clinical Correlation: Osteoarthritis 189

Plate 7 Hyaline Cartilage 194

Plate 8 Cartilage and the Developing Skeleton 196

Plate 9 Elastic Cartilage 198

Plate 10 Fibrocartilage 200

8 Bone 202

Overview of Bone 202

Bones and Bone Tissue 203

General Structure of Bones 205

Cells of Bone Tissue 208

Bone Formation 217

Biologic Mineralization and Matrix Vesicles 224

Physiologic Aspects of Bone 225

Box 8.1 Clinical Correlation: Joint Diseases 205

Box 8.2 Clinical Correlation: Nutritional Factors in Bone Formation 217

Box 8.3 Functional Considerations: Hormonal Regulation of Bone Growth 226

Plate 11 Bone, Ground Section 228

Plate 12 Spongy and Compact Bone 230

Plate 13 Endochondral Bone Formation I 232

Plate 14 Endochondral Bone Formation II 234

Plate 15 Intramembranous Bone Formation 236

9 Adipose Tissue 238

Overview of Adipose Tissue 238

White Adipose Tissue 238

Brown Adipose Tissue 244

Box 9.1 Clinical Correlation: Obesity 243

Box 9.2 Clinical Correlation: Adipose Tissue Tumors 245

10 Blood 247

Overview of Blood 247

Plasma 248

Erythrocytes 250

Leukocytes 253

Thrombocytes 262

Formation of Blood Cells (Hemopoiesis) 264

Bone Marrow 273

Box 10.1 Clinical Correlation: ABO and Rh Blood Group Systems 252

Box 10.2 Clinical Correlation: Hemoglobin Disorders 254

Box 10.3 Clinical Correlation: Hemoglobin Breakdown and Jaundice 270

Box 10.4 Clinical Correlation: Cellularity of the Bone Marrow 274

Plate 16 Erythrocytes and Agranulocytes 276

Plate 17 Granulocytes 278

11 Muscle Tissue 280

Overview and Classification of Muscle 280

Skeletal Muscle 281

Cardiac Muscle 296

Smooth Muscle 300

Box 11.1 Functional Considerations: Muscle Metabolism and Ischemia 285

Box 11.2 Clinical Correlation: Muscular Dystrophy-Dystrophin and Dystrophin-Associated Proteins 290

Box 11.3 Functional Considerations: The Sliding Filament Model 291

Box 11.4 Clinical Correlation: Myasthenia Gravis 294

Box 11.5 Functional Considerations: Comparison of the Three Muscle Types 306

Plate 18 Skeletal Muscle 308

Plate 19 Musculotendinous Junction and Neuromuscular Junction 310

Plate 20 Cardiac Muscle 312

Plate 21 Cardiac Muscle, Purkinje Fibers 314

Plate 22 Smooth Muscle 316

12 Nerve Tissue 318

Overview of the Nervous System 319

Composition of Nerve Tissue 319

The Neuron 320

Supporting Cells of the Nervous System 329

Origin of Nerve Tissue Cells 340

Organization of the Peripheral Nervous System 341

Organization of the Central Nervous System 348

Response of Neurons to Injury 351

Box 12.1 Clinical Correlation: Parkinson's Disease 324

Box 12.2 Clinical Correlation: Demyelinating Diseases 336

Plate 23 Sympathetic and Dorsal Root Ganglia 354

Plate 24 Peripheral Nerve 356

Plate 25 Cerebrum 358

Plate 26 Cerebellum 360

Plate 27 Spinal Cord 362

13 Cardiovascular System 364

Overview of the Cardiovascular System 364

Heart 365

General Features of Arteries and Veins 370

Arteries 372

Capillaries 379

Arteriovenous Shunts 382

Veins 383

Lymphatic Vessels 385

Box 13.1 Clinical Correlation: Hypertension 372

Box 13.2 Clinical Correlation: Atherosclerosis 379

Box 13.3 Clinical Correlation: Ischemic Heart Disease 386

Plate 28 Heart 388

Plate 29 Aorta 390

Plate 30 Muscular Arteries and Veins 392

Plate 31 Arterioles and Lymphatic Vessels 394

14 Lymphatic System 396

Overview of the Lymphatic System 396

Cells of the Lymphatic System 397

Lymphatic Tissues and Organs 410

Box 14.1 Functional Considerations: Origin of the Names T Lymphocyte and B Lymphocyte 401

Box 14.2 Clinical Correlation: Hypersensitivity Reactions 402

Box 14.3 Clinical Correlation: Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) 408

Plate 32 Tonsil 430

Plate 33 Lymph Node I 432

Plate 34 Lymph Node II 434

Plate 35 Spleen I 436

Plate 36 Spleen II 438

Plate 37 Thymus 440

15 Integumentary System 442

Overview of the Integumentary System 442

Layers of the Skin 443

Cells of the Epidermis 446

Structures of Skin 452

Box 15.1 Functional Considerations: Skin Color 451

Box 15.2 Functional Considerations: Hair Growth and Hair Characteristics 456

Box 15.3 Functional Characteristics: The Role of Sebum 457

Box 15.4 Clinical Correlation: Sweating and Disease 461

Box 15.5 Clinical Correlation: Skin Repair 463

Plate 38 Skin I 464

Plate 39 Skin II 466

Plate 40 Eccrine and Apocrine Sweat Glands 468

Plate 41 Sweat and Sebaceous Glands 470

Plate 42 Integument and Sensory Organs 472

Plate 43 Hair Follicle and Nail 474

16 Digestive System I: Oral Cavity and Associated Structures 476

Overview of the Digestive

System 476

Oral Cavity 477

Tongue 478

Teeth and Supporting Tissues 483

Salivary Glands 495

Box 16.1 Clinical Correlation: The Genetic Basis of Taste 482

Box 16.2 Clinical Correlation: Classification of Permanent (Secondary) and Deciduous (Primary) Dentition 483

Box 16.3 Clinical Correlation: Dental Caries 496

Box 16.4 Clinical Correlation: Salivary Glands Tumors 504

Plate 44 Lip, a Mucocutaneous Junction 506

Plate 45 Tongue I 508

Plate 46 Tongue II 510

Plate 47 Submandibular Gland 512

Plate 48 Parotid Gland 514

Plate 49 Sublingual Gland 516

17 Digestive System II: Esophagus and Gastrointestinal Tract 518

Overview of the Esophagus and Gastrointestinal Tract 519

Esophagus 522

Stomach 524

Small Intestine 535

Large Intestine 545

Box 17.1 Clinical Correlation: Pernicious Anemia and Peptic Ulcer Disease 528

Box 17.2 Functional Considerations: Enteroendocrine Cells, APUD Cells, and Gastrointestinal Hormones 534

Box 17.3 Clinical Correlation: Zollinger-Ellison Syndrome 534

Box 17.4 Functional Considerations: Digestive and Absorptive Functions of Enterocytes 546

Box 17.5 Functional Considerations: Immune Functions of the Alimentary Canal 553

Plate 50 Esophagus 554

Plate 51 Esophagus and Stomach, Cardiac Region 556

Plate 52 Stomach I 558

Plate 53 Stomach II 560

Plate 54 Gastroduodenal Junction 562

Plate 55 Duodenum 564

Plate 56 Jejunum 566

Plate 57 Ileum 568

Plate 58 Colon 570

Plate 60 Anorectal Junction 574

18 Digestive System III: Liver, Gallbladder, and Pancreas 576

Liver 576

Gallbladder 591

Pancreas 594

Box 18.1 Clinical Correlation: Congestive Heart Failure and Liver Necrosis 583

Box 18.2 Clinical Correlation: Lipoproteins 589

Box 18.3 Functional Considerations: Insulin Synthesis, an Example of Posttranslational Processing 602

Plate 61 Liver I 604

Plate 62 Liver II 606

Plate 63 Gallbladder 608

Plate 64 Pancreas 610

19 Respiratory System 612

Overview of the Respiratory System 612

Nasal Cavities 613

Pharynx 617

Larynx 617

Trachea 617

Bronchi 623

Bronchioles 623

Alveoli 625

Blood Supply 630

Lymphatic Vessels 634

Nerves 634

Box 19.1 Clinical Correlation: Metaplasia 619

Box 19.2 Clinical Correlation: Cystic Fibrosis 626

Box 19.3 Clinical Correlation: Emphysema and Pneumonia 632

Plate 65 Olfactory Mucosa 636

Plate 66 Larynx 638

Plate 67 Trachea 640

Plate 68 Bronchiole and End Respiratory Passages 642

Plate 69 Wall of Terminal Bronchiole, Respiratory Bronchiole, and Alveolus 644

20 Urinary System 646

Overview of the Urinary System 647

General Structure of the Kidney 647

Kidney Tubule Function 660

Interstitial Cells 665

Histophysiology of the Kidney 666

Blood Supply 667

Lymphatic Vessels 667

Nerve Supply 668

Ureter, Urinary Bladder, and Urethra 669

Box 20.1 Functional Considerations: Vitamin D 647

Box 20.2 Clinical Correlation: Urinalysis 658

Box 20.3 Clinical Correlation: Renin-Angiotensin-Aldosterone System and Hypertension 659

Box 20.4 Functional Considerations: Structure and Function of Aquaporin Water Channels 662

Box 20.5 Functional Considerations: Hormonal Regulation of Collecting Duct Function 666

Plate 70 Kidney I 674

Plate 71 Kidney II 676

Plate 72 Kidney III 678

Plate 73 Kidney IV 680

Plate 74 Ureter 682

Plate 75 Urinary Bladder 684

21 Endocrine Organs 686

Overview of the Endocrine System 686

Pituitary Gland (Hypophysis) 689

Hypothalamus 697

Pineal Gland 698

Thyroid Gland 700

Parathyroid Glands 705

Adrenal Glands 706

Box 21.1 Functional Considerations: Regulation of Pituitary Gland Secretion 695

Box 21.2 Clinical Correlation: Diabetes Insipidus and ADH 697

Box 21.3 Functional Considerations: Feedback Control of Thyroid Hormone Synthesis 703

Box 21.4 Clinical Correlation: Abnormal Thyroid Function 704

Box 21.5 Functional Considerations: Chromaffin Cells 710

Box 21.6 Functional Considerations: Biosynthesis of Adrenal Hormones 713

Plate 76 Pituitary I 716

Plate 77 Pituitary II 718

Plate 78 Pineal Gland 720

Plate 79 Parathyroid and Thyroid Glands 722

Plate 80 Adrenal Gland I 724

Plate 81 Adrenal Gland II 726

22 Male Reproductive System 728

Overview of the Male Reproductive System 728

Testis 729

Spermatogenesis 734

Seminiferous Tubules 742

Intratesticular Ducts 746

Excurrent Duct System 746

Accessory Sex Glands 751

Semen 757

Penis 757

Box 22.1 Functional Considerations: Hormonal Regulation of Spermatogenesis 736

Box 22.2 Clinical Correlation: Factors Affecting Spermatogenesis 742

Box 22.3 Clinical Correlation: Sperm-Specific Antigens and the Immune Response 745

Box 22.4 Clinical Correlation: Benign Prostatic Hypertrophy and Cancer of the Prostate 755

Box 22.5 Clinical Correlation: Mechanism of Erection and Erectile Dysfunction 758

Plate 82 Testis I 760

Plate 83 Testis II 762

Plate 84 Ductuli Efferentes and Epididymis 764

Plate 85 Spermatic Cord and Ductus Deferens 766

Plate 86 Prostate Gland 768

Plate 87 Seminal Vesicle 770

23 Female Reproductive System 772

Overview of the Female Reproductive System 773

Ovary 773

Uterine Tubes 788

Uterus 790

Placenta 796

Vagina 801

External Genitalia 803

Mammary Glands 804

Box 23.1 Clinical Correlation: Polycystic Ovarian Disease 781

Box 23.2 Clinical Correlation: In Vitro Fertilization 785

Box 23.3 Functional Considerations: Summary of Hormonal Regulation of the Ovarian Cycle 787

Box 23.4 Clinical Correlation: Fate of Mature Placenta at Birth 801

Box 23.5 Clinical Correlation: Cytologic Pap Smears 803

Box 23.6 Functional Considerations: Lactation and Infertility 809

Plate 88 Ovary I 810

Plate 89 Ovary II 812

Plate 90 Corpus Luteum 814

Plate 91 Oviduct-Uterine Tube 816

Plate 92 Uterus I 818

Plate 93 Uterus II 820

Plate 94 Cervix 822

Plate 95 Placenta I 824

Plate 96 Placenta II 826

Plate 97 Vagina 828

Plate 98 Mammary Gland 830

Plate 99 Mammary Gland, Late Proliferative and Lactating 832

24 Eye 834

Overview of the Eye 834

General Structure of the Eye 834

Microscopic Structure of the Eye 838

Box 24.1 Clinical Correlation: Glaucoma 845

Box 24.2 Clinical Correlation: Retinal Detachment 847

Box 24.3 Clinical Correlation: Age-Related Macular Degeneration (ARMD) 852

Plate 100 Eye I 858

Plate 101 Eye II: Retina 860

Plate 102 Eye III: Anterior Segment 862

Plate 103 Eye IV: Sclera, Cornea, and Lens 864

25 Ear 866

Overview of the Ear 866

External Ear 866

Middle Ear 867

Internal Ear 870

Box 25.1 Clinical Correlation: Vertigo 877

Box 25.2 Clinical Correlation: Hearing Loss-Vestibular Dysfunction 881

Plate 104 Ear 884

Plate 105 Organ of Corti 886.

Notes:

Includes index.

Local Notes:

Acquired for the Penn Libraries with assistance from the Clarence J. Marshall Memorial Library Fund.

Acquired for the Penn Libraries with assistance from the Anne and Joseph Trachtman Memorial Book Fund.

Some copies lack CD-ROM.

ISBN:

0781750563

OCLC:

60516651