Tissue stem cells / edited by Christopher S. Potten ... [and others].

Format:

Book

Contributor:

Potten, C. S., 1940-2012.

Language:

English

Subjects (All):

Stem cells.

Stem Cells.

Medical Subjects:

Stem Cells.

Physical Description:

xiv, 403 pages, 8 pages of plates : illustrations (some color) ; 26 cm

Place of Publication:

New York : Taylor & Francis, 2006.

Summary:

Tissue stem cells and their medical applications have become a major focus of research over the past decade. With 16 full-color illustrations, this reference provides a thorough and up-to-date overview of the current and emerging technologies for stem cell research and transplantation. Divided into three sections covering general issues, adult stem cells within specific tissues, and clinical applications, this source studies advances in bone marrow transplantation, cancer development modeling, tumor analysis, and gene therapy.

With contributions by internationally-regarded experts in the field, this source spans ethical issues surrounding the therapeutic use of stem cells and stem cell transplantation...focuses on a variety of concepts within stem cell research including the molecular biology of stem cell regulation, experimental models of stem cell function, and the clinical applications of stem cell biology...and addresses controversial issues such as the debate between stem cell trans-differentiation and stem cell fusion, and the mathematical modeling of stem cells in tissues.

Contents:

1 Mathematical Modeling of Stem Cells: A Complexity Primer for the Stem-Cell Biologist / Mark d'Inverno, Neil Theise, Jane Prophet 1

Emergence 5

Complex Adaptive Systems with Multiple Interacting Agents 7

Modeling Stem Cells and Cell Lineages as Complex Adaptive Systems 8

Ramifications for Current Thinking 13

2 Theoretical Concepts of Tissue Stem-Cell Organization / Ingo Roeder, Joerg Galle, Markus Loeffler 17

Defining Tissue Stem Cells 18

Conceptual Challenges in Tissue Stem-Cell Biology 18

Predictive Theories and Quantitative Models 19

A New Perspective on Stem-Cell Systems 20

Modeling of the Dynamics of Clonal Competition in Hematopoietic Stem Cells 22

Spatio-Temporal Stem-Cell Organization 26

Conceptual Novelty and Achievements 29

3 Mechanisms of Genetic Fidelity in Mammalian Adult Stem Cells / James L. Sherley 37

Evolution of Mechanisms of Mammalian Tissue Cell Genetic Fidelity: The Needs of a Few 37

An Exact Definition for the Long-Lived Nature of ASCs 39

Mutagenesis Mechanisms in ASCs 40

Immortal DNA Strand Co-Segregation and a Carpenter's Rule for Genetic Fidelity in ASCs 41

Implications of the Carpenter's Rule for ASC Aging, Cell Kinetics, and DNA Repair Functions 43

Estimation of the Mutation-Avoidance Effect of an Immortal DNA Strand Mechanism in ASCs 45

Evidence for Immortal DNA Strand Co-Segregation in ASCs 47

4 Neural Stem Cells: Isolation and Self-Renewal / Hideyuki Okano, Jun Kohyama, Hiroyuki Ohba, Masanori Sakaguchi, Akinori Tokunaga, Takuya Shimazaki, Hirotaka James Okano 55

In Vivo Localization of NSCs 55

Control of the Self-Renewal and Differentiation of NSCs 60

5 Stem Cells in Mammary Epithelium / Gilbert H. Smith, Robert B. Clarke 71

Aging and Reproductive Senescence 72

In Vitro Studies 72

Mammary Stem-Cell Markers 76

Mammary Stem Cells in Carcinogenesis 82

Pregnancy and Breast Cancer Risk 84

Future Prospects 84

6 Lineage Tracking, Regulation, and Behaviors of Intestinal Stem Cells / Melissa H. Wong, Adnan Z. Rizvi 89

Intestinal Epithelium 89

Lineage Tracking as an Approach to Understanding the Stem-Cell Behavior 96

Tracking Stem-Cell Fate Through Understanding What Regulates Their Proliferation and Differentiation 101

Identifying Markers for Intestinal Stem Cells 109

7 Stem Cell Populations in Skin / Richard P. Redvers, Pritinder Kaur 117

8 A Perspective on In Vitro Clonogenic Keratinocytes: A Window into the Regulation of the Progenitor Cell Compartment of the Cutaneous Epithelium / Rebecca J. Morris 149

Cutaneous Epithelium as a Continually Renewing Tissue Containing In Vitro Clonogenic Keratinocytes 149

Functional Evidence of Stem Cells in Epidermis and Hair Follicles 150

In Mice, Keratinocyte Colony Number is Genetically Defined and Quantitatively Complex 157

Keratinocyte Colony Size is Also Genetically Defined 158

9 Hepatic Stem Cells and the Liver's Maturational Lineages: Implications for Liver Biology, Gene Expression, and Cell Therapies / Eva Schmelzer, Randall E. McClelland, Aloa Melhem, Lili Zhang, Hsin-lei Yao, Eliane Wauthier, William S. Turner, Mark E. Furth, David Gerber, Sanjeev Gupta, Lola M. Reid 161

The Liver as a Maturational Lineage System 161

General Comments on Stem Cells 168

Hepatic Stem Cells 169

Gene Expression 183

Reconstitution of Liver by Cell Transplantation 188

Liver Cell Therapies-Clinical Programs 193

10 Multistage Carcinogenesis: From Intestinal Stem Cell to Colon Cancer in the Population / E. Georg Luebeck 215

A Biologically Based Multistage Model for Colon Cancer 217

Adenomatous Polyps-Observations and Model Predictions 221

11 Intestinal Stem Cells and the Development of Colorectal Neoplasia / Stuart A. C. McDonald, Trevor Graham, Christopher S. Potten, Nicholas A. Wright, Ian P. M. Tomlinson, Andrew G. Renehan 229

Basic Structure and Function of the Intestinal Crypt 230

Stem-Cell Hierarchy 234

Crypt Clonality 236

Intestinal Stem-Cell Repertoire 238

The Concept of Stemness and "Immortal" DNA Strands 239

Molecular Regulation of Normal Intestinal Crypt Homeostasis 242

Early Molecular Events in Colorectal Tumorigenesis 250

Intestinal Stem Cells and the Origin of Colorectal Cancer 252

Colorectal Tumor Morphogenesis 253

Clinical Implications and Future Directions 256

12 Stem Cells in Neurodegeneration and Injury / Reaz Vawda, Nigel L. Kennea, Huseyin Mehmet 271

Stem Cells 272

The Use of Stem Cells in Brain Disease and Injury 285

13 Adult Stem Cells and Gene Therapy / Ilaria Bellantuono, Leslie J. Fairbairn 305

Adult Stem Cells for Gene Therapy 306

Gene Delivery 310

Hurdles to Stem-Cell Gene Therapy 315

14 Clinical Applications of Hematopoietic Stem Cells / Joanne Ewing, Yvonne Summers 339

Clinical Use of HSCs in Transplantation 339

Autologous Stem-Cell Transplantation 341

ASCT: Malignant Diseases 343

ASCT: Nonmalignant Diseases 351

Allogeneic Stem-Cell Transplantation 353

Specific Clinical Indications for Allogeneic Transplant 357

Cord Blood Transplantation 363.

Notes:

Includes bibliographical references and index.

ISBN:

0824728998

OCLC:

62736852

Publisher Number:

9780824728991