Inhalation toxicology / edited by Harry Salem, Sidney A. Katz.

Format:

Book

Contributor:

Salem, Harry, 1929-

Katz, Sidney A., 1935-

Language:

English

Subjects (All):

Gases, Asphyxiating and poisonous--Toxicity testing.

Gases, Asphyxiating and poisonous.

Gases, Asphyxiating and poisonous--Physiological effect.

Air Pollutants--toxicity.

Respiratory System--drug effects.

Medical Subjects:

Air Pollutants--toxicity.

Respiratory System--drug effects.

Physical Description:

1034 pages : illustrations ; 27 cm

Edition:

Second edition.

Place of Publication:

Boca Raton, FL : CRC Taylor & Francis, 2006.

Summary:

Written by internationally recognized scientists from academic, industrial, and governmental sectors, Inhalation Toxicology, Second Edition details the methods, mechanisms, and materials used in the theoretical and applied aspects of inhalation toxicology. The editors emphasize the relationship between the respiratory system and toxicology of inhaled substances and examine methods and measurements for improving our understanding of the basic mechanisms of effects.

The book delineates key issues in the field such as regulatory aspects of exposure and testing, testing equipment and methods, biomarkers, pathology, allergies and immunology, irritation of the respiratory tract, and risk assessment. It covers the inhalation of bioaerosols and toxins, ranging from anthrax to household molds as well as genomics, proteomics, and low-level exposure toxicants such as tobacco smoke and chemical warfare agents. Highlights include coverage of the Acute Exposure Guidelines and Emergence Response Guidelines and recent changes in the European and American guidelines for testing procedures.

The book focuses on key issues associated with airborne substances and provides critical reviews of the latest advances. Presenting sophisticated concepts in a readable, accessible format, the book distills the latest information into practical knowledge.

Contents:

Part I Inhalation Toxicology: Methods and Measurements

Chapter 1 Inhalation Risk Assessment at the Environmental Protection Agency / John E. Whalan, Gary L. Foureman, John J. Vandenberg 3

Chapter 2 The Development and Application of Acute Exposure Guideline Levels for Hazardous Substances / George M. Rusch 39

Chapter 3 Emergency Response Planning Guidelines (ERPGs) / Finis Cavender 61

Chapter 4 Directed-Flow Aerosol Inhalation Exposure Systems: Applications to Pathogens and Highly Toxic Agents / Rudolph J. Jaeger, Susan G. Shami, Liana Tsenova 73

Chapter 5 Low-Level Effects of VX Vapor Exposure on Pupil Size and Cholinesterase Levels in Rats / Bernard J. Benton, Douglas R. Sommerville, J. Steven Anthony, Ronald B. Crosier, Edward M. Jakubowski, Christopher E. Whalley, Paul A. Dabisch, Stanley W. Hulet, Kathy L. Matson, Charles L. Crouse, Robert J. Mioduszewski, Sandra A. Thomson 91

Chapter 6 Application of Intratracheal Instillation Exposure to the Etiological Determination of a Pulmonary Disease Outbreak: Nylon Flock as an Example / Dale W. Porter, Ann F. Hubbs 109

Chapter 7 The Use of Large Animals in Inhalation Toxicology / R.F.R. Brown, B.J.A. Jugg, J. Jenner 119

Chapter 8 Toxic Load Modeling / Douglas R. Sommerville, Kyong H. Park, Michael O. Kierzewski, Michael D. Dunkel, Matthew I. Hutton, Nirmala A. Pinto 137

Chapter 9 Inhalation Toxicology and Carcinogenicity Studies of the National Toxicology Program / Elizabeth K. Weisburger, Vera W. Hudson 159

Chapter 10 Toxicology of Fire and Smoke / Barbara C. Levin, Erica D. Kuligowski 205

Part II Inhalation Toxicology Methods

Chapter 11 Toxicogenomics of Low-Level Nerve Agent Vapor Exposure / Janet Weeks Sekowski 231

Chapter 12 Respiratory Sensitization / Malcolm Blackwell 243

Chapter 13 Peripheral Chemosensory Irritation with Particular Reference to Respiratory Tract Exposure / Bryan Ballantyne 269

Chapter 14 Role of Cytokines in Pulmonary Inflammation and Fibrosis Induced by Inhaled Mineral Particles / Francois Huaux 307

Chapter 15 Hormesis: Implications for Risk Assessment / Edward J. Calabrese 335

Chapter 16 Nasal Toxicology / John B. Morris 349

Chapter 17 Effects of Inhaled Toxicants on the Nose and Nasal Function / Pamela Dalton, Richard Opiekum 373

Chapter 18 Toxicokinetics: Deposition, Absorption, Distribution, and Excretion / Mario A. Inchiosa 405

Chapter 19 Mechanistic Determinants and Modeling of the Inhalation Pharmacokinetics of Volatile Organic Chemicals / Andy Nong, Kannan Krishnan 439

Chapter 20 Inhalation Toxicology of an Irritant Gas-Historical Perspectives, Current Research, and Case Studies of Phosgene Exposure / Alfred M. Sciuto 457

Chapter 21 Inhalation Toxicology of Riot Control Agents / Harry Salem, Bryan Ballantyne, Sidney A. Katz 485

Chapter 22 Chemical Warfare Agents and Nuclear Weapons / Nabil M. Elsayed, Harry Salem 521

Chapter 23 The Inhalation Toxicology of Chromium Compounds / Sidney A. Katz, Bryan Ballantyne, Harry Salem 543

Chapter 24 Safety Assessment of Therapeutic Agents Administered by the Respiratory Route / Shayne C. Gad 565

Chapter 25 Nonclinical Pharmacology and Safety Studies of Insulin Administered to the Respiratory Tract / Gregory L. Finch 609

Part III Inhalation Toxicology of Materials

Chapter 26 Inhalation Toxicology of Alcohol/Gasoline Fuels-Current Status / Raymond Poon 623

Chapter 27 Asbestos / David M. Bernstein 647

Chapter 28 The Inhalation Toxicity of Benzene / Robert Snyder, Marcel Van Raaij 669

Chapter 29 Carbon Monoxide / James J. McGrath 695

Chapter 30 Experimental, Clinical, Occupational Toxicology, and Forensic Aspects of Hydrogen Cyanide with Particular Reference to Vapor Exposure / Bryan Ballantyne, Harry Salem 717

Chapter 31 The Pharmacology and Toxicology of Inhaled Dusts, Endotoxins, and Glucans / Samantha R. Lane, Paul J. Nicholls, Robert. D.E. Sewell 803

Chapter 32 Fluorocarbon Alternatives-Methodologies for Special Studies and Results / Darol E. Dodd, William J. Brock 825

Chapter 33 Animal Models for Three Major Cigarette-Smoke-Induced Diseases / Raymond R. Schleef, Patrick M. Vanscheevwijck, Walter K. Schlage, Joseph F. Borzelleca, Christopher R.E. Coggins, Hans-Juergen Haussmann 851

Chapter 34 The Impact of Active and Passive Exposure to Cigarette Smoke on Maternal and Fetal Health / Sher-Janel T. Todd, Stanley T. Omaye 875

Part IV Inhalation Toxicology of Bioaerosols

Chapter 35 Health Aspects of Bioaerosols / Kevin P. O'Connell, Harry Salem 913

Chapter 36 Emerging Biothreats: Natural and Deliberate / Jessica M. Mann, Nancy D. Connell 933

Chapter 37 Toxicology Associated with Respiratory Exposures to Fungi (Molds) / Marsha D. W. Ward, Yong Joo Chung, MaryJane K. Selgrade 945

Chapter 38 Inhalation Toxicity of Botulinum Neurotoxin / Michael Adler 963

Chapter 39 Inhalation Ricin: Aerosol Procedures, Animal Toxicology, and Therapy / Robert W. Wannemacher, Jamie B. Anderson 973

Chapter 40 Toxicity, Mechanisms, Prophylaxis, and Therapy of Inhaled Biological Toxins / Brian M. Paddle 983.

Notes:

Errata slip inserted.

Includes bibliographical references and index.

ISBN:

0849340497

OCLC:

61027811