Handbook of models for human aging / editor P. Michael Conn.

Format:

Book

Contributor:

Conn, P. Michael.

Language:

English

Subjects (All):

Aging--Handbooks, manuals, etc.

Aging.

Models, Animal.

Models, Biological.

Medical Subjects:

Aging.

Models, Animal.

Models, Biological.

Genre:

Handbooks and manuals.

Physical Description:

xxi, 1075 pages, 4 pages of plates : illustrations (partly color) ; 29 cm

Place of Publication:

Burlington, MA : Elsevier Academic Press, [2006]

Summary:

This Handbook is designed as the only comprehensive work available that covers the diversity of aging models currently available. For each animal model, it presents key aspects of biology, nutrition, factors affecting life span, methods of age determination, use in research, and disadvantages/advantes of use. Chapters on comparative models take a broad sweep of age-related diseases, from Alzheimer's to joint disease, cataracts, cancer, and obesity. In addition, there is an historical overview and discussion of model availability, key methods, and ethical issues. *Utilizes a multidisciplinary approach *Shows tricks and approaches not available in primary publications *First volume of its kind to combine both methods of study for human aging and animal models *Over 200 illustrations

Contents:

Historical development of animal models of aging / Richard L. Sprott and Steven N. Austad

Species selection in comparative studies of aging and antiaging research / João Pedro de Magalhães

Principles of animal use for gerontological research / Richard A. Miller

From primary cultures to the aging organism: lessons from human T lymphocytes / Rita B. Effros

Models of systems failure in aging / Leonid A. Gavrilov, Natalia S. Gavrilova

Major issues in ethics of aging research / Michael D. Smith

Ethical aspects of research involving elderly persons / Paul S. Mueller and C. Christopher Hook

SAGE KE and other online sources related to aging / Evelyn Strauss and R. John Davenport

Proteomics in aging research / Christian Schöneich

Application of high-throughput technologies to aging-related research / Matt Kaeberlein

Models of Alzheimer's disease / Harry LeVine III and Lary C. Walker

Age-related hippocampal dysfunction: early Alzheimer's disease vs. normal aging / Scott A. Small

Epidemiology in aging research / Hermann Brenner and Volker Arndt

Statistical issues for longevity studies in animal models / Chenxi Wang ... [et al.]

Models for the study of infection in populations / John R. Williams

Estimation of the rate of production of oxygen radicals by mitochondria / Alberto Sanz and Gustavo Barja

Telomeres and aging in the yeast model system / Kurt W. Runge

Longevity and aging in budding yeast / Matt Kaeberlein

From yeast Methuselah genes to evolutionary medicine / Paola Fabrizio and Valter D. Longo

Strongyloides ratti: a nematode with extraordinary plasticity in aging / Michael P. Gardner, David Gems, and Mark E. Viney

Insect models for the study of aging / Klaus-Günter Collatz

Drosophila models of aging / Satomi Miwa and Alan Cohen

Models of aging in honeybee workers / Gro V. Amdam and Olav Rueppell

Ants as naturally long-lived insect models for aging / Joel D. Parker and Karen M. Parker

Gene expression and the extended longevity phenotypes of drosophila melanogaster / Robert Arking

Annual fish as a genetic model for aging / Pudur Jagadeeswaran

The use of mature zebrafish (Danio rerio) as a model for human aging and disease / Evan T. Keller, Jill M. Keller, Gavin Gillespie

Zebrafish as aging models / Shuji Kishi

Telomeres in aging: birds / Susan E. Swanberg, Mary E. Delany

Domestic and wild bird models for the study of aging / Donna J. Holmes and Mary Ann Ottinger

A transgenic mini rat strain as a tool for studying aging and calorie restriction / Isao Shimokawa

Rat models of age-related cognitive decline / Jennifer L. Bizon and Michelle M. Nicolle

Aged rodents for biogerontology research / Nancy L. Nadon

Life extension in the dwarf mouse / Andrzej Bartke

The canine model of human brain aging: cognition, behavior, and neuropathology / P. Dwight Tapp and Christina T. Siwak

Bats as a novel model for aging research / Anja K Brunet-Rossinni and Rocco E. Rossinni

Memory in the aging hippocampus: what can place cells tell us? / Iain A. Wilson

The rhesus macaque as a model of human aging and age-related disease / Mary Ann Ottinger ... [et al.]

Nonhuman primates as a model for reproductive aging and human infertility / Barry D. Bavister and Carol A. Brenner

Neurobiology of the aging brain / Carlo Bertoni-Freddari ... [et al.]

Mitochondrial DNA and aging / Mikhail Alexeyev, Susan P. LeDoux and Glen L. Wilson

Models for apoptosis: from newborn to adult / Christiane Charriaut-Marlangue and Sylvain Renolleau

Age-related changes in hormones and their receptors in animal models of female reproductive senescence / Jacqueline A. Maffucci and Andrea C. Gore

Models of chaperones in aging / Jens Krøll and J.O. Nehlin

Therapeutic potential of stem cells in aging-related diseases / Shannon Whirledge, Kirk C. Lo, and Dolores J. Lamb

Nuclear transfer and cloning: preservation or expansion of proliferative lifespan? / Keith E Latham

Human models of longevity / Thomas Perls

Computational models of mitochondrial DNA in aging / David C. Samuels

Mouse models of accelerated aging / Jan Vijg and Paul Hasty

Models, definitions, and criteria of frailty / David B. Hogan

Fertility and aging men: an introduction to the male biological clock / Peter N Schlegel ... [et al.]

Benign prostatic hyperplasia / Peter Celec

Murine models of infectious diseases in the aged / Kevin P. High

Studying infection in the elderly: physiopathology, clinical symptoms, and causative agents of pneumonia / Jean-Paul Janssens

Diabetes and aging / Tamas Fülöp ... [et al.]

Diabetes as a model of premature aging / Arshag D. Mooradian

Frailty as a model of aging / Jeremy D. Walston

Osteoporosis and cardiovascular disease in the elderly / Samy I. McFarlane, John Nicasio, and Ranganath Muniyappa

Depression in older patients / Kiran Rabheru

The aging human lung: age-associated changes in structure and function / Keith C. Meyer

Iceland as a model for human aging / Adalsteinn Gudmundsson, and Pálmi V. Jónsson

Behavior and personality in the study of successful aging / Judith Corr and Loraine Tarou

Andropause / Rabih Hijazi and Glenn R. Cunningham

Aging and the perceptual organization of sounds: a change of scene? / Claude Alain, Benjamin J. Dyson, and Joel S. Snyder

Models of immune function in aging / Christopher A. Jolly and Zhun Xu

Human T cell clones in long-term culture as models for the impact of chronic antigenic stress in aging / Graham Pawelec ... [et al.]

Age-related changes in the human retina / Carlo Cavallotti and Nicola Pescosolido

Models of age-related vision problems / J. Fielding Hejtmancik, Mark Kantorow, and Takeshi Iwata

Health, functional and therapeutic implications of obesity in aging / R. Lee Kennedy and E.Y.H. Khoo

Age and joints / Klaus Bobacz and Ilse-Gerlinde Sunk

Sleep quality in the elderly / Ragnar Asplund

Atherogenesis and aging / Cam Patterson

Managing menopausal symptons / Mary Ellen Rousseau

Psychological aging: a contextual view / Hans-Werner Wahl and Frieder R. Lang

Nutrients and aging / Lawrence J. Whalley

Methods for studying hearing impairment and auditory problems of the aged / Robert D. Frisina and D. Robert Frisina

A model for understanding the pathomechanics of osteoarthritis in aging / Thomas P. Andriacchi and Annegret Mündermann

Aging and cardiovascular angiogenesis models / Andrew Chin ... [et al.]

Models for the study of stroke / Thiruma V. Arumugam, Mark P. Mattson

Werner syndrome as a model of human aging / Raymond J. Monnat Jr.

Models of sarcopenia / Alfred L. Fisher

Aging of human skin / Paolo U. Giacomoni

Models of hypertension in aging / Jane F. Reckelhoff ... [et al.].

Notes:

Includes bibliographical references and index.

ISBN:

0123693918

OCLC:

61499966

Publisher Number:

9780123693914