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Metal-based neurodegeneration : from molecular mechanisms to therapeutic strategies / Robert R. Crichton & Roberta J. Ward.
Table of contents Available online
View onlineHolman Biotech Commons RC365 .C75 2006
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- Format:
- Book
- Author/Creator:
- Crichton, Robert R.
- Language:
- English
- Subjects (All):
- Nervous system--Degeneration--Etiology.
- Nervous system.
- Brain--Pathophysiology.
- Brain.
- Oxidative stress.
- Metals--Health aspects.
- Metals.
- Neurodegenerative Diseases--etiology.
- Brain--physiology.
- Metals--adverse effects.
- Oxidative Stress.
- Nervous system--Degeneration.
- Diseases--Causes and theories of causation.
- Medical Subjects:
- Neurodegenerative Diseases--etiology.
- Brain--physiology.
- Metals--adverse effects.
- Oxidative Stress.
- Physical Description:
- x, 227 pages : illustrations (some color) ; 25 cm
- Place of Publication:
- Chichester ; Hoboken, NJ : J. Wiley & Sons, [2006]
- Summary:
- This exciting new book opens a window into the causes of debilitating neurological disorders such as Parkinson' s disease, CJD and Huntington' s disease, and gives indications of the prospects for therapy, based on the understanding of molecular defects involved in these diseases.
- Looking at each specific neurological disorder in turn, the book outlines the role of metals in human biology, in particular in the brain and explores tools for testing potential therapeutic strategies. It concludes with an overview of the potential of both chelation and antioxidant therapy and outlines some perspectives for the future.
- Contents:
- Metals in brain, metal transport, storage and homeostasis
- Oxidative stress and redox-active metal ions
- Parkinson's disease
- Alzheimer's disease
- Huntington's disease and polyglutamine expansion neurodegenerative diseases
- Friedreich's ataxia and diseases associated with expansion of non-coding triplets
- Creutzfeldt-Jakob and other prion diseases
- Amyotrophic lateral sclerosis
- Other neurological diseases
- Therapeutic strategies to combat the onset and progression of neurodegenerative diseases
- Animal models of the various neurodegenerative diseases
- Concluding remarks.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 0470022558
- OCLC:
- 61334482
- Publisher Number:
- 9780470022559
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