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The Myc/Max/Mad transcription factor network / R.N. Eisenman (ed.).
Holman Biotech Commons QR1 .E6 v.302 2006
Available
Holman Biotech Commons QR1 .E6 v.253 (2001)-v.363,v.367-v.371
Available
Veterinary: Atwood Library (Campus) QR181 O75 2000
Available
LIBRA v.40 (1967)-v.113 (1984), v.115 (1985)-v.203 (1995), v.205 (1996)-v.252 (2000)
Available from offsite location
Levy Dental Medicine Library - Stacks QR1 .E6 215,271
Mixed Availability
Veterinary: du Pont Library (New Bolton) QR1 .E6 280
Mixed Availability
Veterinary: Atwood Library (Campus) QR1 .E6 271
Mixed Availability
- Format:
- Book
- Series:
- Current topics in microbiology and immunology ; v. 302.
- Current topics in microbiology and immunology. 0070-217X ; 302.
- Current topics in microbiology and immunology, 0070-217X ; 302
- Language:
- English
- Subjects (All):
- Myc oncogenes.
- Myc proteins.
- Oncogenes.
- Proto-Oncogene Proteins c-myc.
- Medical Subjects:
- Oncogenes.
- Proto-Oncogene Proteins c-myc.
- Physical Description:
- vii, 282 pages : illustrations (some color) ; 25 cm.
- Place of Publication:
- Berlin ; New York : Springer, 2006.
- Summary:
- Intense study of the enigmatic myc proto-oncogene over the last 20 years has broadened our view of its functions and led to insights into transcriptional regulation as well as cancer etiology, cell proliferation, apoptosis, and organismal development. How can one gene be involved in so many aspects of cellular behavior? Of particular interest is the fact that the Myc protein functions as part of a network (comprising Myc, Max, and Mad proteins) whose specific interactions direct transcriptional activation or repression of a large number of target genes. The chapters in this volume examine both molecular and biological aspects of the Myc/Max/Mad network. Included are contributions concerning the regulation of its expression, the mechanisms underlying its diverse transcriptional activities, the structural bases for its critical interactions, and the nature of its target genes. Other chapters explore the evolution of the network, its role in development and genomic instability, and the evidence for a parallel transcriptional network. Overall, this volume provides a broad and current overview of research on a crucial group of transcription factors.
- Contents:
- Making Myc / J. Liu, D. Levens 1
- Transcriptional Activation by the Myc Oncoprotein / M. D. Cole, M. A. Nikiforov 33
- Mechanisms of Transcriptional Repression by Myc / D. Kleine-Kohlbrecher, S. Adhikary, M. Eilers 51
- The Mad Side of the Max Network: Antagonizing the Function of Myc and More / S. Rottmann, B. Luscher 63
- Structural Aspects of Interactions Within the Myc/Max/Mad Network / S. K. Nair, S. K. Burley 123
- Myc Target Transcriptomes / L. A. Lee, C. V. Dang 145
- c-Myc, Genome Instability, and Tumorigenesis: The Devil Is in the Details / M. Wade, G. M. Wahl 169
- Lessons Learned from Myc/Max/Mad Knockout Mice / M. Pirity, J. K. Blanck, N. Schreiber-Agus 205
- Myc/Max/Mad in Invertebrates: The Evolution of the Max Network / P. Gallant 235
- The Mix Network: Evidence for a Parallel Max-Like Transcriptional Network That Regulates Energy Metabolism / A. N. Billin, D. E. Ayer 255.
- Notes:
- Includes bibliographical references and index.
- ISBN:
- 3540239685
- OCLC:
- 64399257
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